mefae

macrolide efflux pump

Validation StatusCandidate

Overview

Mechanism: efflux
Validation Method: PCR and MIC testing
Drug Classes: Macrolide
Organisms: Streptococcus pneumoniae
Geographic Location: Brazil
Papers: 2
Databases: Reslit

Papers2

Emergence and persistence of macrolide resistance in oropharyngeal flora and elimination of nasal carriage of Staphylococcus aureus after therapy with slow-release clarithromycin: a randomized, double-blind, placebo-controlled study.

PMID 15504839 · 2004

The study found that treatment with slow-release clarithromycin led to increased macrolide resistance in oropharyngeal flora, with significant rises in ermB and ermC genes in streptococci and staphylococci, respectively.

Gene Information

Gene Name: mefae
Allele: mefAE
Encodes: macrolide efflux pump
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Streptococcus pneumoniae
Validation Method: PCR and MIC testing

Co-occurrence of mcr-1, mcr-3, mcr-7 and clinically relevant antimicrobial resistance genes in environmental and fecal samples.

PMID 32382766 · 2020

The study identified the co-occurrence of mcr-1, mcr-3, mcr-7.1, and various clinically relevant antimicrobial resistance genes in environmental and fecal samples from a Brazilian zoo, highlighting the potential reservoir of these genes in zoological environments.

Gene Information

Gene Name: mefae
Allele: mefAE
Encodes: macrolide efflux pump
Source Database: Reslit
Mechanism: efflux
Confers Resistance To: Macrolide
Geographic Location: Brazil
Validation Method: PCR and sequencing
Sequence Accession: MN174668-MN174693|MN794400-MN794402

Comments (0)

No comments yet. Be the first to comment!

Browse AMR Genes

mefae

Gene Information

Gene Information