Browse AMR Genes

Explore antimicrobial resistance genes from the literature

mepR

transcriptional repressor

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to mepR

Browse AMR rules for mepR

Validation StatusConfirmed2+ DBs

Overview

Mechanism: efflux
Validation Method: mutational analysis
Drug Classes: Tigecycline, Tetracycline, Glycylcyclines, Fluoroquinolone, Aminoglycoside, Macrolide, Phenicol, TIGECYCLINE, Norfloxacin|Chlorhexidine|Ethidium bromide
Organisms: Staphylococcus aureus, Staphylococcus aureus subsp. aureus Mu50
Geographic Location: Germany|Hungary|Europe, Hungary, Malaysia, Saudi Arabia, Shanghai, China +1 more
Papers: 12
Databases: Card DatabaseReslit
Mutations: 6

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G97E	-	multidrug efflux transporter transcriptional repressor MepR	Staphylococcus aureus	TIGECYCLINE	Reference Gene Catalog	Established
A103V	-	multidrug efflux transporter transcriptional repressor MepR, loss of repressor function	Staphylococcus aureus	TIGECYCLINETigecycline	Reference Gene CatalogReslit	Confirmed
Q18P

Papers12

1

Antibiotic Resistance and the MRSA Problem.

PMID 30900543 · 2019

The paper discusses the mechanisms of antibiotic resistance in Staphylococcus aureus, focusing on beta-lactam resistance through the blaZ and mecA genes, glycopeptide resistance via the vanA operon, and resistance to other antibiotics through various genes and mutations.

Gene Information

Gene Name: mepR
Allele: mepR
Encodes: transcriptional repressor
Source Database: Reslit
Confers Resistance To: Tigecycline
Organisms Tested In: • Staphylococcus aureus
Validation Method: mutational analysis

2

Characterization of methicillin-resistant Staphylococcus aureus through genomics approach.

PMID 32864286 · 2020

The study characterized methicillin-resistant Staphylococcus aureus (MRSA) isolates, identifying genes such as mecA, blaZ, norA, gyrA, gyrB, tet-38, mepA, mepR, arlS, arlR, mgrA, clsA, dfrC, msbA, rpoB32, mprF, and mrpA, which confer resistance to various antibiotics.

Gene Information

Gene Name: mepR
Allele: mepR
Encodes: regulator of efflux pump
Source Database: Reslit
Organisms Tested In: • Staphylococcus aureus
Geographic Location: Germany|Hungary|Europe
Validation Method: in silico analysis using CARD database
Sequence Accession: CP032160|CP032468|CP032469|CP032470

3

Whole genome sequencing of coagulase positive staphylococci from a dog-and-owner screening survey.

PMID 33428679 · 2021

The study identified several AMR genes in Staphylococcus aureus isolates, including blaZ, tet(K), norA, lmrS, mepR, and fosB, which confer resistance to penicillin, tetracycline, fluoroquinolones, and fosfomycin. No resistance genes were found in S. pseudintermedius isolates.

Gene Information

Gene Name: mepR
Allele: mepR
Encodes: repressor of mepA
Source Database: Reslit
Confers Resistance To: TetracyclineGlycylcyclines
Organisms Tested In: • Staphylococcus aureus
Geographic Location: Hungary
Validation Method: whole genome sequencing
Sequence Accession: JAEDAR000000000|JAEDAS000000000|JAEDAT000000000|JAEDAU000000000|JAEDAV000000000|JAEEAO000000000

4

Genomic analysis revealed a novel genotype of methicillin-susceptible Staphylococcus aureus isolated from a fatal sepsis case in dengue patient.

PMID 33649330 · 2021

The study identified a novel genotype of methicillin-susceptible Staphylococcus aureus (HS-MSSA) that caused a fatal sepsis case. The strain carries a strain-specific blaZ-bearing plasmid, indicating resistance to penam antibiotics.

Gene Information

Gene Name: mepR
Allele: mepR
Encodes: efflux pump
Source Database: Reslit
Mechanism: efflux
Confers Resistance To: GlycylcyclinesTetracycline
Organisms Tested In: • Staphylococcus aureus
Geographic Location: Malaysia
Validation Method: genomic sequence analysis
Sequence Accession: VCMW00000000|VCMW01000000|NZ_CP017094|NZ_AOCP00000000|CP047022|NC_002951|CP039848|NC_017763

5

Methicillin Resistant Staphylococci Isolated from Goats and Their Farm Environments in Saudi Arabia Genotypically Linked to Known Human Clinical Isolates: a Pilot Study.

PMID 35913203 · 2022

The study identified several AMR genes in methicillin-resistant staphylococci isolates from goats and their farm environments in Saudi Arabia, including mecA, blaZ, norA, lmrS, mepA, mepR, arlR, arlS, tet(38), mecR1, dfrC, fusC, fosB, fexA, tetM, msrA, mphC, fusB, APH(3′)-IIIa, tetK, and dfrG. These genes confer resistance to various antibiotics such as penicillins, fluoroquinolones, aminoglycosides, macrolides, phenicols, diaminopyrimidines, oxazolidinones, tetracyclines, and fosfomycin.

Gene Information

Gene Name: mepR
Allele: mepR
Encodes: tetracycline and glycylcycline resistance
Source Database: Reslit
Confers Resistance To: TetracyclineGlycylcyclines
Organisms Tested In: • Staphylococcus aureus
Geographic Location: Saudi Arabia
Validation Method: whole genome sequencing
Sequence Accession: PRJEB49547

6

Metagenomic identification of pathogens and antimicrobial-resistant genes in bacterial positive blood cultures by nanopore sequencing.

PMID 38192400 · 2023

The study identified various antimicrobial resistance (AMR) genes in bacterial positive blood cultures using nanopore sequencing, demonstrating the effectiveness of this method in detecting resistance mechanisms and pathogens quickly.

Gene Information

Gene Name: mepR
Allele: mepR
Encodes: regulator of mepA
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Staphylococcus aureus
Geographic Location: Shanghai, China
Validation Method: comparison with phenotypic antimicrobial susceptibility testing
Sequence Accession: OEP004528

7

Hybrid Illumina-Nanopore assembly improves identification of multilocus sequence types and antimicrobial resistance genes of Staphylococcus aureus isolated from Vermont dairy farms: comparison to Illumina-only and R9.4.1 nanopore-only assemblies.

PMID 38725589 · 2024

The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from Vermont dairy farms, including beta-lactam resistance genes (blaZ, blaI, blaR), tetracycline resistance genes (tet(K), tet(38)), erythromycin resistance genes (erm(T), erm(A)), lincomycin resistance gene (lnu(G)), aminoglycoside resistance genes (aaC3, ant(9)-la), multidrug resistance efflux pumps (lmrS, mepA, mepR, mepB, norA, norB, arlS, arlR, mgrA), and fosfomycin resistance gene (fosB).

Gene Information

Gene Name: mepR
Allele: mepR
Encodes: efflux pump repressor
Source Database: Reslit
Confers Resistance To: FluoroquinoloneAminoglycosideMacrolidePhenicol
Organisms Tested In: • Staphylococcus aureus
Geographic Location: Vermont
Validation Method: genomic analysis and phenotypic resistance testing
Sequence Accession: PRJNA983748

8

Gene Information

Gene Name: mepR
Allele: mepR
Encodes: multidrug and toxic compound extrusion (MATE) transporter
Source Database: Card Database
Mechanism: antibiotic efflux
Organisms Tested In: • Staphylococcus aureus subsp. aureus Mu50
Sequence Accession: BA000017.4
Protein Accession: BAB56495.1
Notes: ARO:3000746