Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
mercuric reductase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| merA | Reslit | 25 | - |
| South Africa|Philippines|India|United Kingdom, Oak Ridge, TN, Nigeria|Portugal, Mexico, Argentina, Japan|Thailand|Canada|France|Spain|South Korea|United Kingdom|Croatia|Vietnam|global, USA|Australia|Canada|Japan|France|Madagascar|China|Thailand|Germany, Australia, China, Tunisia, Brazil, Tyrrhenian Sea|Panarea|Guaymas basin, Gulf of California, Colombian Amazon|Colombian Amazon basin|Amazon Forest|Tarapacá|Taraira, Malaysia, swine manure, Permafrost sample from Laptev Sea Coast|China|clinical settings, Danakil Depression, Afar Region, Ethiopia, United States, USA|China|Japan|Spain|United Kingdom|Germany|France|South Korea|Netherlands|Viet Nam|Laos|Canada|Czech Republic|Argentina|Brazil|Belgium|Denmark|Iran|Australia|Croatia|Ghana|Mexico|Missing |
| 2002, 2008, 2009, 2013, 2014, 2015, 2017, 2020, 2021, 2022, 2023, 2024 |
| AY090559 |
| - |
| mer | Reslit | 15 | - | Salmonella enterica serovar Choleraesuis +15 | Europe, Mexico, Russia|Siberian Russia, Australia|US|UK, China, Kenya, England|Wales, Guadeloupe, Virginia|Illinois, USA|China|Japan|Spain|United Kingdom|Germany|France|South Korea|Netherlands|Viet Nam|Laos|Canada|Czech Republic|Argentina|Brazil|Belgium|Denmark|Iran|Australia|Croatia|Ghana|Mexico|Missing, Austria, Changsha, Hunan Province, China | 2005, 2011, 2015, 2018, 2019, 2021, 2022, 2023, 2024, 2025 | NC_003143|NC_004061|NC_002528|NC_004741|NC_004631|NC_004545|NC_000913|NC_004431|NC_004088|NC_003198|NC_002695|NC_002655|NC_004344|NC_004337|NC_003197 | - |
| MERA | Reslit | 1 | - | Proteobacteria +3 | Alberta, Canada | 2019 | - | - |
| MER | Reslit | 1 | Meropenem | Bacillus +1 | Brazil | 2025 | OM949960|OM949967|OM949968|OM949990|OM952179|OM952208|OM952259|OM952437|OM952920|OM952921 | - |
R391: a conjugative integrating mosaic comprised of phage, plasmid, and transposon elements.
R391 is a conjugative integrating mosaic element that carries antibiotic and mercury resistance traits. It includes a kanamycin resistance gene (aph) and a mercury resistance operon (merT, merP, merC, merA).
The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen.
The study identifies multiple antimicrobial resistance genes on plasmids pSC138 and pSCV50 in Salmonella enterica serovar Choleraesuis SC-B67, including blaTEM-1, blaCMY-2, tetRA, strA, aadA2, sulI, sulII, catI, cmlA, aph, sat, mef, mer, ebr, qac, and blaTEM-67. Additionally, mutations in the chromosomal genes gyrA and parC, along with the inactivation of acrR, contribute to ciprofloxacin resistance.
Cultivation of hard-to-culture subsurface mercury-resistant bacteria and discovery of new merA gene sequences.
The study discovered new merA gene sequences from mercury-resistant bacteria isolated using an advanced cultivation method, highlighting the diversity of merA genes in subsurface soils.
A novel transposon, Tn6009, composed of a Tn916 element linked with a Staphylococcus aureus mer operon.
The study identifies a novel transposon, Tn6009, which contains the tet(M) gene linked to the Staphylococcus aureus mer operon, conferring resistance to tetracycline and mercury.
Non mycobacterial virulence genes in the genome of the emerging pathogen Mycobacterium abscessus.
The study identifies several non-mycobacterial genes in Mycobacterium abscessus that contribute to its virulence and pathogenicity, including genes involved in mercury resistance, intracellular survival, and oxidative stress resistance.
Salmonella Typhimurium ST213 is associated with two types of IncA/C plasmids carrying multiple resistance determinants.
The study identifies bla CMY-2, dfrA12, orfF, aadA2, floR, and mer as resistance genes carried by IncA/C plasmids in Salmonella Typhimurium ST213, contributing to multidrug resistance.
Mainstreams of horizontal gene exchange in enterobacteria: consideration of the outbreak of enterohemorrhagic E. coli O104:H4 in Germany in 2011.
The study identified various genomic islands (GIs) in enterobacteria, including those carrying antibiotic resistance genes such as beta-lactamase (bla), tetracycline efflux protein (tet), and mercury resistance operon (mer). These GIs were found to be horizontally transferred and contributed to the virulence and resistance profiles of the strains analyzed.
Characterization and potential application in mercury bioremediation of highly mercury-resistant marine bacterium Bacillus thuringiensis PW-05.
The study identifies the merA gene in Bacillus thuringiensis PW-05, which is responsible for mercury resistance through the volatilization of mercury. The gene was experimentally validated using real-time PCR.
Characterization of mercury-resistant clinical Aeromonas species.
The study characterizes mercury-resistant clinical Aeromonas species, identifying the presence of merA and merR genes in some strains, indicating a high variability in mer operons among these bacteria.
Living in an Extremely Polluted Environment: Clues from the Genome of Melanin-Producing Aeromonas salmonicida subsp. pectinolytica 34melT.
The study identifies several heavy metal resistance genes in Aeromonas salmonicida subsp. pectinolytica 34melT, including merA, copA, arsA, chrA, and zntA, which confer resistance to mercury, copper, arsenite, chromate, and heavy metals respectively.
Healthcare- and Community-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) and Fatal Pneumonia with Pediatric Deaths in Krasnoyarsk, Siberian Russia: Unique MRSA's Multiple Virulence Factors, Genome, and Stepwise Evolution.
The study identifies multiple antimicrobial resistance genes in MRSA strains from Krasnoyarsk, Siberian Russia, including mecA, blaZ, ermA, ermC, cat, aacA-aphD, aadD, tet, spc, ble, qacA, cad, and mer, which confer resistance to various antibiotics such as methicillin, ampicillin, erythromycin, clindamycin, chloramphenicol, gentamicin, kanamycin, tetracycline, spectinomycin, bleomycin, quaternary ammonium compounds, cadmium, and mercury.
Insight into the mobilome of Aeromonas strains.
The study characterizes various antibiotic resistance genes (ARG) in Aeromonas strains, highlighting the presence of beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and others. These genes are often located on plasmids and contribute to multidrug resistance.
Comparative Sequence Analysis of Multidrug-Resistant IncA/C Plasmids from Salmonella enterica.
The study identified multiple antimicrobial resistance genes on IncA/C plasmids from various Salmonella serovars, including bla_cmy-2, bla_tem-1, strA, strB, aadB, aph(3')-Ia, tetA, floR, cmlA, sul1, sul2, dfra12, quacE, sugE, merA, merB, merC, merD, and merE, which contribute to multidrug resistance.
Porcine commensal Escherichia coli: a reservoir for class 1 integrons associated with IS26.
The study identified 17 antimicrobial resistance genes (ARGs) in 103 class 1 integron-positive Escherichia coli strains from porcine feces, highlighting the prevalence of multidrug-resistant commensal E. coli in pigs and their potential role in the dissemination of resistance genes.
Genetic structure of four plasmids found in Acinetobacter baumannii isolate D36 belonging to lineage 2 of global clone 1.
The study identifies four plasmids in Acinetobacter baumannii isolate D36, including pRAY* carrying aadB, pD36-4 carrying aphA1a, sul2, and a mercury resistance module, and others with no resistance genes.
Emerging Multidrug-Resistant Hybrid Pathotype Shiga Toxin-Producing Escherichia coli O80 and Related Strains of Clonal Complex 165, Europe.
The study identifies multidrug-resistant hybrid pathotype Shiga toxin-producing E. coli O80 strains belonging to clonal complex 165, which harbor a mosaic plasmid with genes conferring resistance to multiple antibiotics, including beta-lactams, tetracyclines, sulfonamides, trimethoprim, kanamycin, streptomycin, and colistin.
Comparative diversity of microbiomes and Resistomes in beef feedlots, downstream environments and urban sewage influent.
The study identified several tetracycline, macrolide, aminoglycoside, beta-lactam, sulfonamide, mercury, and biocide resistance genes in beef feedlots, catch basin water, soil, and urban sewage influent. Tetracycline resistance was predominant in beef production systems, while urban sewage influent showed a diverse resistome with resistance to multiple antimicrobial classes.
First Report of Coexistence of Three Different MDR Plasmids, and That of Occurrence of IMP-Encoding Plasmid in Leclercia adecarboxylata.
The study reports the first identification of three different multidrug-resistant (MDR) plasmids in a single clinical isolate of Leclercia adecarboxylata, including the blaIMP-8 gene encoded on an IMP-encoding plasmid. These plasmids harbor various AMR genes such as blaIMP-8, aacC2, aadA2, mph(A), sul1, qacED1, mer, chrA, dfrA12, tmrB, catA1, catB8, tet(C), blaCTX-M-9, and blaTEM-1.
The Impact of Mercury Selection and Conjugative Genetic Elements on Community Structure and Resistance Gene Transfer.
The study identified the integration of a 52 kb integrative and conjugative element (ICE6775) encoding mercury resistance into the Pseudomonas fluorescens SBW25 chromosome, which conferred specific mercury resistance.
Colonization of a hand washing sink in a veterinary hospital by an Enterobacter hormaechei strain carrying multiple resistances to high importance antimicrobials.
The study identified multiple antimicrobial resistance genes in an Enterobacter hormaechei strain isolated from a veterinary hospital sink, including blaSHV-12, qnrB2, and mcr-9.1, which confer resistance to cephalosporins, quinolones, and colistin, respectively.
Effects of in ovo probiotic administration on the incidence of avian pathogenic Escherichia coli in broilers and an evaluation on its virulence and antimicrobial resistance properties.
The study identified various antimicrobial resistance genes in APEC isolates, including blaTEM, aac(3)-VIa, aac(3)-VIb, aadA, tetA, tetB, dfr7, qacEΔ, qnr, sul1, intl1, arsC, and merA. These genes conferred resistance to multiple antibiotics such as beta-lactams, aminoglycosides, tetracyclines, quinolones, sulfonamides, and heavy metals.
Comparative genomic and phenotypic characterization of invasive non-typhoidal Salmonella isolates from Siaya, Kenya.
The study identified several AMR genes in Salmonella isolates from Kenya, including blaTEM-1, aadA1, strA, strB, catA1, dhfr1, sul1, and sul2, which confer resistance to various antibiotics such as penicillins, cephalosporins, streptomycin, chloramphenicol, trimethoprim, and sulfonamides.
First Description of Various Bacteria Resistant to Heavy Metals and Antibiotics Isolated from Polluted Sites in Tunisia.
The study identified the presence of blaTEM, blaSHV, silE, cusA, and merA genes in environmental bacteria isolated from polluted sites in Tunisia, indicating resistance to antibiotics and heavy metals.
Characterization of a pESI-like plasmid and analysis of multidrug-resistant Salmonella enterica Infantis isolates in England and Wales.
The study characterizes a pESI-like plasmid harboring multiple resistance genes, including bla CTX-M-65, in multidrug-resistant Salmonella enterica Infantis isolates from England and Wales. The plasmid was associated with resistance to beta-lactams, aminoglycosides, chloramphenicol, tetracyclines, trimethoprim, sulfonamides, fosfomycin, and heavy metals.
Genomic features of a multidrug-resistant and mercury-tolerant environmental Escherichia coli recovered after a mining dam disaster in South America.
The study identifies a multidrug-resistant Escherichia coli strain (B2C) carrying the bla CTX-M-2 ESBL gene, qacE∆1 efflux pump, and the mer operon, indicating resistance to antibiotics, heavy metals, and disinfectants.
Shallow-Water Hydrothermal Vents as Natural Accelerators of Bacterial Antibiotic Resistance in Marine Coastal Areas.
The study identifies multiple heavy metal resistance (HMR) genes in bacterial isolates from shallow-water hydrothermal vents, demonstrating co-selection for antibiotic resistance (AR) in these environments.
Highly mercury-resistant strains from different Colombian Amazon ecosystems affected by artisanal gold mining activities.
The study identified highly mercury-resistant bacterial strains from the Colombian Amazon, with most strains possessing the merA gene, which confers mercury resistance through mercury reduction activity. The strains Pseudomonas sp. TP30 and Burkholderia contaminans TR100 exhibited high mercury resistance and potential for bioremediation.
Emergence of a Novel Lineage and Wide Spread of a bla(CTX-M-15)/IncHI2/ST1 Plasmid among Nosocomial Enterobacter in Guadeloupe.
The study identifies the bla CTX-M-15 gene as the most prevalent ESBL determinant in ESBL-producing Enterobacter cloacae complex isolates, along with the IncHI2/ST1 plasmid. It also reports the presence of other resistance genes such as mcr-9, aac(3)-IIa, aac(6′)-Ib-cr, aph(3″)-Ib, aph(6)-Id, bla OXA-1, bla TEM-1B, qnrB1, fosA, sul2, tet(A), dfrA14, ars, mer, tni, and the ter operon.
Hiding in Plain Sight: Characterization of Aeromonas Species Isolated from a Recreational Estuary Reveals the Carriage and Putative Dissemination of Resistance Genes.
The study identified various antimicrobial resistance genes, including beta-lactamases such as bla TEM-1, bla CTX-M-2, bla KPC-2, bla OXA-726, imiH, bla OXA-18, and bla TOHO-1, as well as the mcr-3 gene for colistin resistance in Aeromonas hydrophila strain 34SFC-3. Additionally, the presence of the intI1 gene and merA gene for mercury resistance was noted.
The Plasmidomic Landscape of Clinical Methicillin-Resistant Staphylococcus aureus Isolates from Malaysia.
The study identified various plasmid-borne antimicrobial resistance genes in Malaysian MRSA isolates, including ermC, cat, tetK, tetL, aadD, aac(6')-Ie-aph(2")-Ia, lnuA, cadAC, cadDX, copB, mco, arsB, arsC, and qacA, contributing to multidrug resistance.
Antibiotic-Resistant Desulfovibrio Produces H(2)S from Supplements for Animal Farming.
The study identifies multiple antibiotic resistance genes in Desulfovibrio vulgaris L2, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and mercury resistance genes, highlighting its potential role in spreading antibiotic resistance in agricultural environments.
Conjugative Plasmid pPPUT-Tik1-1 from a Permafrost Pseudomonas putida Strain and Its Present-Day Counterparts Inhabiting Environments and Clinics.
The study characterizes the conjugative plasmid pPPUT-Tik1-1 from a permafrost Pseudomonas putida strain and identifies antibiotic resistance genes such as strA, merA, and blaVIM-2, along with mercury resistance determinants.
Characterization of a mobilizable megaplasmid carrying multiple resistance genes from a clinical isolate of Pseudomonas aeruginosa.
The study identifies a 522.5 kb mobilizable megaplasmid, pBJ86, carrying multiple resistance genes including tmexCD-oprJ, blaDIM-1, qnrVC6, and mer operon, which can be transferred via conjugation and contribute to multidrug resistance in Pseudomonas aeruginosa.
Shotgun Metagenomics-Guided Prediction Reveals the Metal Tolerance and Antibiotic Resistance of Microbes in Poly-Extreme Environments in the Danakil Depression, Afar Region.
The study identified numerous antibiotic resistance genes (ARGs) and metal resistance genes (MRGs) in the metagenomes of Lake Afdera and the Assale salt plain in the Danakil Depression. Key ARGs included beta-lactamases (ACC-1, OXA-58, OXA-363, OXA-212, NDM-17, OXA-134, ACT-29, LRA-19), efflux pumps (emrB, abeM, abeS, mgrA, adeJ, MexC, adeL, adeH), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet39, tetX, tetK), and others. MRGs included copper resistance genes (copC, copD), cadmium resistance gene (cadD), mercury resistance gene (merA), chromate resistance genes (chrB, chrA), nickel-cobalt-cadmium resistance genes (nccA, nccB), cobalt-zinc-cadmium resistance gene (czcD), arsenic resistance gene (arsO), lead resistance gene (pbrA), and mercury resistance genes (merB, merR, MIR).
Selection and horizontal gene transfer underlie microdiversity-level heterogeneity in resistance gene fate during wastewater treatment.
The study identifies several resistance genes, including mphA, msrE, tet(39), sul1, sul2, mer, qac, and aadA, which were found to be associated with hospital sewage and showed variations in their persistence in activated sludge. These genes contribute to resistance against macrolides, tetracyclines, sulfonamides, mercury, quaternary ammonium compounds, and aminoglycosides.
Comprehensive Genomic Analysis of Uropathogenic E. coli: Virulence Factors, Antimicrobial Resistance, and Mobile Genetic Elements.
The study identified numerous antimicrobial resistance genes and mutations in uropathogenic E. coli isolates, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and quinolone resistance genes. Mutations in gyrA, parC, parE, and marR were associated with fluoroquinolone resistance, while mutations in PmrB, CyaA, GlpT, PtsI, and UhpT were linked to fosfomycin resistance.
Antisense transcription is associated with expression of metal resistance determinants in Cupriavidus metallidurans CH34.
The study identifies several metal resistance genes in Cupriavidus metallidurans CH34, including merA, merT, arsC2, arsC1, arsB, arsR, czcC2, tauD, atoD, czcC, copF, copD, copC, copB, copA, copR, copS, cupR, cupA, cupC, silC, silB, silA, gshA, and gshB, which are up-regulated under metal stress conditions and are associated with antisense transcription activities.
The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes.
The study characterizes various resistance genes carried by incompatible plasmids in Gram-negative bacteria, highlighting their role in the spread of antibiotic resistance. Key genes include beta-lactamases like bla VIM-1, bla SHV-12, bla TEM-1B, and bla CTX-M-15, as well as sulfonamide resistance genes sul1 and sul2, tetracycline resistance gene tetA, and polymyxin resistance gene mcr-1.
The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes.
The study characterizes various resistance genes carried by incompatible plasmids in Gram-negative bacteria, highlighting their role in the spread of antibiotic resistance. Key genes include beta-lactamases like bla VIM-1, bla SHV-12, bla TEM-1B, and bla CTX-M-15, as well as sulfonamide resistance genes sul1 and sul2, tetracycline resistance gene tetA, and polymyxin resistance gene mcr-1.
Antimicrobial and Metal Resistance Genes in Bacteria Isolated from Mine Water in Austria.
The study identified a variety of antimicrobial and metal resistance genes in bacteria isolated from mine water in Austria, highlighting the prevalence of multidrug efflux pumps and beta-lactamase genes. It also noted the presence of specific metal resistance genes such as ruvB, copA, recGM, and mgtA, as well as co-resistance genes like arsBM, acrD, and the mer operon.
Tolerance to Herbicides and Resistance to Antibacterial Drugs of Bacterial Isolates From the Guarani Aquifer System (Brazil).
The study identified multiple antibiotic-resistant bacterial isolates from the Guarani Aquifer System, highlighting the correlation between herbicide tolerance and antibiotic resistance.
Whole-genome sequencing characterization of silver-resistant bacteria from the outfall of wastewater treatment plants and effluent-receiving rivers.
The study identified the sil and pco operons as key contributors to silver resistance in bacteria isolated from wastewater treatment plants and effluent-receiving rivers. These operons, along with other heavy metal resistance genes, were found to be prevalent in the isolates, highlighting the environmental dissemination of silver resistance genes.
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