Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
multidrug efflux RND transporter periplasmic adaptor subunit MexA
Overview
Reslit |
| Candidate |
| E178K | - | - | Pseudomonas aeruginosa | Meropenem | Reslit | Candidate |
| G195D | - | - | Pseudomonas aeruginosa | Piperacillin/tazobactam|Ceftazidime|Cefepime|Meropenem|Imipenem|Tobramycin|Ciprofloxacin | Reslit | Candidate |
| - | - | Pseudomonas aeruginosa | Fluoroquinolones | Reslit | Candidate |
| - | - | Pseudomonas aeruginosa | Fluoroquinolones | Reslit | Candidate |
| - | - | Pseudomonas aeruginosa | Fluoroquinolones | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| MexA | Card DatabaseReference Gene CatalogReslit | 19 | EFFLUX, Ofloxacin +22 | Pseudomonas aeruginosa +5 | India, Egypt, France, Northwestern Transylvania, Romania, Europe | 2004, 2012, 2015, 2018, 2019, 2020, 2021, 2023, 2024, 2025 | L11616.1 | AAA74436.1 |
| mex A | Reslit | 1 | Fluoroquinolone, Aminoglycoside +1 | Pseudomonas aeruginosa | Romania | 2023 | - | - |
| Mex | Reslit | 1 | Cephalosporins, Beta-lactams/beta-lactamase inhibitors +2 | Klebsiella pneumoniae +2 | Zhejiang | 2024 | - | - |
| mex | Reslit | 1 | - | Pseudomonas spp. | Austria | 2025 | PRJNA1224714 | - |
Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa.
Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa.
The regulatory repertoire of Pseudomonas aeruginosa AmpC ß-lactamase regulator AmpR includes virulence genes.
AmpR is a global regulator in P. aeruginosa that influences the expression of over 500 genes, including those involved in β-lactam resistance, virulence, and biofilm formation.
Transcriptional Analysis of MexAB-OprM Efflux Pumps System of Pseudomonas aeruginosa and Its Role in Carbapenem Resistance in a Tertiary Referral Hospital in India.
Overexpression of the MexAB-OprM efflux pump was found to contribute significantly to meropenem resistance in Pseudomonas aeruginosa isolates lacking acquired resistance mechanisms.
Application of six multiplex PCR's among 200 clinical isolates of Pseudomonas aeruginosa for the detection of 20 drug resistance encoding genes.
The study identified several beta-lactamase genes (blaTem, blaOXA, blaCTX-M-15, blaVim, blaGes, blaVeb, blaDIM, AmpC) and efflux pump genes (MexA, MexB, OprM, MexC, MexD, OprJ, MexX, MexY, OprN, nfxB, MexR, OprD) in Pseudomonas aeruginosa clinical isolates, highlighting their roles in mediating resistance to various antibiotics.
MexAB-OprM Efflux Pump of Pseudomonas aeruginosa Offers Resistance to Carvacrol: A Herbal Antimicrobial Agent.
The study identifies the mexA gene as part of the MexAB-OprM efflux pump, which mediates resistance to carvacrol in Pseudomonas aeruginosa.
Cigarette Smoke Exposure Promotes Virulence of Pseudomonas aeruginosa and Induces Resistance to Neutrophil Killing.
Cigarette smoke exposure increases the resistance of Pseudomonas aeruginosa to neutrophil killing and oxidative stress, and upregulates genes involved in multidrug efflux pumps, contributing to its virulence.
Full pathogen characterisation: species identification including the detection of virulence factors and antibiotic resistance genes via multiplex DNA-assays.
The study presents a DNA microarray-based assay for the simultaneous detection of 44 sepsis-relevant bacterial pathogens, 360 virulence factors, and 409 antibiotic resistance genes. The assay was evaluated with 14 multidrug-resistant strains, including all ESKAPE pathogens.
Development of a rapid and sensitive analytical system for Pseudomonas aeruginosa based on reverse transcription quantitative PCR targeting of rRNA molecules.
The study developed a rapid and sensitive RT-qPCR system for detecting Pseudomonas aeruginosa, including drug-resistant strains. It identified the presence of drug resistance genes such as mexA, ampC, and blaIMP in fecal samples of ICU patients.
Effect of Titanium Dioxide Nanoparticles on the Expression of Efflux Pump and Quorum-Sensing Genes in MDR Pseudomonas aeruginosa Isolates.
The study identified that titanium dioxide nanoparticles (TDN) significantly downregulate the expression of efflux pump genes (MexY, MexB, MexA, oprM) and quorum-sensing regulated genes (lasI, lasR, rhlI, rhlR, pqsA, pqsR) in MDR P. aeruginosa isolates, suggesting potential as efflux pump inhibitors and anti-quorum sensing agents.
A 10-year microbiological study of Pseudomonas aeruginosa strains revealed the circulation of populations resistant to both carbapenems and quaternary ammonium compounds.
The study identified blaVIM-2 and blaGES-5 as carbapenem resistance genes and the overexpression of the MexAB-OprM efflux pump as a mechanism for resistance to DDAC in Pseudomonas aeruginosa.
Uncovering the Resistance Mechanisms in Extended-Drug-Resistant Pseudomonas aeruginosa Clinical Isolates: Insights from Gene Expression and Phenotypic Tests.
The study identified bla GES-2, bla OXA48-like, bla NDM, bla SPM, and bla VIM as the main carbapenemase genes in MDR P. aeruginosa isolates. Overexpression of mex efflux pumps, particularly mex C, was strongly associated with multidrug resistance.
Proteomic analysis of ceftazidime and meropenem-exposed Pseudomonas aeruginosa ATCC 9027.
The study identified ampC, oprD, mexA, and mexB as key genes involved in the resistance of Pseudomonas aeruginosa to ceftazidime and meropenem through proteomic analysis and qRT-PCR validation.
Microbiological and molecular studies on a multidrug-resistant Pseudomonas aeruginosa from a liver transplant patient with urinary tract infection in Egypt.
The study identified 59 AMR genes in the multidrug-resistant P. aeruginosa strain EMARA01, with a focus on resistance-nodulation-cell division (RND) efflux pumps. Key genes include nalC, nalD, MexR, MexA, MexB, CpxR, and OprM, which confer resistance to multiple antibiotic classes.
Phenotypic and genotypic assessment of fluoroquinolones and aminoglycosides resistances in Pseudomonas aeruginosa collected from Minia hospitals, Egypt during COVID-19 pandemic.
The study identified qnrS, qnrA, qnrD, aac(6')-Ib, rmtB, and mexA as the main genes contributing to fluoroquinolone and aminoglycoside resistance in P. aeruginosa isolates during the COVID-19 pandemic.
From Proteome to Potential Drugs: Integration of Subtractive Proteomics and Ensemble Docking for Drug Repurposing against Pseudomonas aeruginosa RND Superfamily Proteins.
The study identifies and characterizes essential proteins in Pseudomonas aeruginosa, particularly RND efflux pumps, which are critical for antibiotic resistance. Computational methods and ensemble docking were used to find potential inhibitors like MK-3207, R-428, and Suramin, showing promise for drug repurposing.
Clinical and metagenomic predicted antimicrobial resistance in pediatric critically ill patients with infectious diseases in a single center of Zhejiang.
The study identified multiple antimicrobial resistance genes, including efflux pumps (Mex, ade, mdt, Mux, Opm) and beta-lactamase (OXA), in Gram-negative bacteria such as Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. These genes conferred resistance to cephalosporins, beta-lactams/beta-Lactamase inhibitors, carbapenems, and sulfonamides.
The Difference a Year Can Make: How Antibiotic Resistance Mechanisms in Pseudomonas aeruginosa Have Changed in Northwestern Transylvania.
The study identified an increase in multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa isolates in Northwestern Transylvania, Romania, between 2022 and 2023. Key AMR genes included bla OXA-50, sul1, ermB, mexA, mexB, bla VIM-1, aac(6′)-II, ant(4′)-Ia, aac(3)-I, aac(6′)-Im, aph(2″)-Ib, tetA, tetC, tetK, qnrB, ermC, mphC, fosA, nfsA, nfsB, ampC, and TEM-1.
Antimicrobial and Metal Resistance Genes in Bacteria Isolated from Mine Water in Austria.
The study identified a variety of antimicrobial and metal resistance genes in bacteria isolated from mine water in Austria, highlighting the prevalence of multidrug efflux pumps and beta-lactamase genes. It also noted the presence of specific metal resistance genes such as ruvB, copA, recGM, and mgtA, as well as co-resistance genes like arsBM, acrD, and the mer operon.
An NGS-assisted diagnostic workflow for culture-independent detection of bloodstream pathogens and prediction of antimicrobial resistances in sepsis.
The study evaluated the diagnostic performance of PISTE™ technology, an NGS-based workflow for detecting bloodstream pathogens and predicting antimicrobial resistance. It showed high accuracy in identifying pathogens and predicting resistance genes, including beta-lactamases, carbapenemases, aminoglycoside modifying enzymes, tetracycline efflux pumps, and quinolone resistance proteins.
Minimal gene signatures enable high-accuracy prediction of antibiotic resistance in Pseudomonas aeruginosa.
The study identifies minimal gene signatures for high-accuracy prediction of antibiotic resistance in Pseudomonas aeruginosa, highlighting the role of efflux pumps, metabolic adaptations, and porin alterations in resistance mechanisms.
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