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mexC

Efflux pump component

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to mexC

Browse AMR rules for mexC

Validation StatusSupported

Overview

Mechanism: overexpression due to UV-induced oxidative stress
Validation Method: multiplex PCR
Drug Classes: Fluoroquinolone, Aminoglycoside, Tetracycline, Macrolide, Ciprofloxacin, Penicillin, Cephalosporin, Carbapenem, Diaminopyrimidines, Aminocoumarin, Chloramphenicol, Piperacillin/tazobactam|Ceftazidime|Cefepime|Meropenem|Imipenem|Tobramycin|Ciprofloxacin, Levofloxacin, Ciprofloxacin|Levofloxacin, Tigecycline, Ciprofloxacin|Norfloxacin|Imipenem|Meropenem, Imipenem|Meropenem|Ciprofloxacin, Fluoroquinolones
Organisms: Pseudomonas aeruginosa, Delftia tsuruhatensis MR-6/3H
Geographic Location: Europe|Denmark, India, Russia
Papers: 14
Databases: Reslit
Mutations: 11

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G195D	-	-	Pseudomonas aeruginosa	Piperacillin/tazobactam\|Ceftazidime\|Cefepime\|Meropenem\|Imipenem\|Tobramycin\|Ciprofloxacin	Reslit	Candidate
E251Q	-	-	Pseudomonas aeruginosa	LevofloxacinCiprofloxacin\|Levofloxacin	Reslit	Candidate
A262E	-	-	Pseudomonas aeruginosa

Papers14

1

Application of six multiplex PCR's among 200 clinical isolates of Pseudomonas aeruginosa for the detection of 20 drug resistance encoding genes.

PMID 29413231 · 2018

The study identified several beta-lactamase genes (blaTem, blaOXA, blaCTX-M-15, blaVim, blaGes, blaVeb, blaDIM, AmpC) and efflux pump genes (MexA, MexB, OprM, MexC, MexD, OprJ, MexX, MexY, OprN, nfxB, MexR, OprD) in Pseudomonas aeruginosa clinical isolates, highlighting their roles in mediating resistance to various antibiotics.

Gene Information

Gene Name: mexC
Allele: MexC
Encodes: Efflux pump component
Source Database: Reslit
Confers Resistance To: FluoroquinoloneAminoglycoside
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: India
Validation Method: multiplex PCR

2

Transcriptome Analysis Reveals the Resistance Mechanism of Pseudomonas aeruginosa to Tachyplesin I.

PMID 32021330 · 2020

The study identifies several efflux pump genes, including mexB, mexC, mexR, armR, and others, that are upregulated in tachyplesin I-resistant Pseudomonas aeruginosa strains, suggesting their role in resistance through increased efflux of the antimicrobial peptide.

Gene Information

Gene Name: mexC
Allele: MexC
Encodes: RND multidrug efflux membrane fusion protein MexC
Source Database: Reslit
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: RNA-Seq and RT-qPCR

3

Full pathogen characterisation: species identification including the detection of virulence factors and antibiotic resistance genes via multiplex DNA-assays.

PMID 33727586 · 2021

The study presents a DNA microarray-based assay for the simultaneous detection of 44 sepsis-relevant bacterial pathogens, 360 virulence factors, and 409 antibiotic resistance genes. The assay was evaluated with 14 multidrug-resistant strains, including all ESKAPE pathogens.

Gene Information

Gene Name: mexC
Allele: MexC
Encodes: efflux pump component
Source Database: Reslit
Confers Resistance To: FluoroquinoloneTetracyclineMacrolide
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: microarray detection

4

Antimicrobials and Food-Related Stresses as Selective Factors for Antibiotic Resistance along the Farm to Fork Continuum.

PMID 34199740 · 2021

This review discusses how non-antibiotic antimicrobials and food-related stresses can act as selective factors for antibiotic resistance along the farm-to-fork continuum, emphasizing the role of agrochemicals, biocides, heavy metals, and food preservatives in promoting resistance mechanisms in foodborne bacteria.

Gene Information

Gene Name: mexC
Allele: MexC
Encodes: MexCD-OprJ efflux pump component
Source Database: Reslit
Mechanism: overexpression due to UV-induced oxidative stress
Confers Resistance To: CiprofloxacinTetracycline
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: gene expression analysis

5

Genomic analysis of multidrug-resistant Delftia tsuruhatensis isolated from raw bovine milk.

PMID 38239723 · 2023

The study identifies multiple efflux pump genes and a genus-specific OXA-926-like beta-lactamase in the multidrug-resistant Delftia tsuruhatensis strain MR-6/3H, contributing to resistance against various antibiotics.

Gene Information

Gene Name: mexC
Allele: MexC
Encodes: efflux pump
Source Database: Reslit
Mechanism: efflux pump
Confers Resistance To: PenicillinCephalosporinCarbapenemAminoglycosideFluoroquinoloneDiaminopyrimidinesTetracyclineAminocoumarinMacrolide
Organisms Tested In: • Delftia tsuruhatensis MR-6/3H
Geographic Location: Russia
Validation Method: genomic analysis
Sequence Accession: PRJNA903655|JAPMID000000000

6

From Proteome to Potential Drugs: Integration of Subtractive Proteomics and Ensemble Docking for Drug Repurposing against Pseudomonas aeruginosa RND Superfamily Proteins.

PMID 39125594 · 2024

The study identifies and characterizes essential proteins in Pseudomonas aeruginosa, particularly RND efflux pumps, which are critical for antibiotic resistance. Computational methods and ensemble docking were used to find potential inhibitors like MK-3207, R-428, and Suramin, showing promise for drug repurposing.

Gene Information

Gene Name: mexC
Allele: MexC
Encodes: membrane fusion protein
Source Database: Reslit
Mechanism: efflux pump
Confers Resistance To: FluoroquinoloneChloramphenicolTetracycline
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: ensemble docking and non-covalent interaction index

7

Ciprofloxacin resistance rapidly declines in nfxB defective clinical strains of Pseudomonas aeruginosa.

PMID 40467543 · 2025

The study demonstrates that ciprofloxacin resistance in nfxB-defective Pseudomonas aeruginosa clinical strains can rapidly decline in antibiotic-free environments due to compensatory mutations in the mexCD-oprJ operon, particularly in mexC and mexD genes.

Gene Information

Gene Name: mexC
Allele: MexC
Encodes: efflux pump component
Source Database: Reslit
Mechanism: overproduction of MexCD-OprJ efflux pump leads to ciprofloxacin resistance
Confers Resistance To: Ciprofloxacin
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Europe|Denmark
Validation Method: whole-genome sequencing and MIC testing
Sequence Accession: NCBI BioProject PRJNA123456