Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
efflux pump protein
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G195D | - | - | Pseudomonas aeruginosa | Piperacillin/tazobactam|Ceftazidime|Cefepime|Meropenem|Imipenem|Tobramycin|Ciprofloxacin | Reslit | Candidate |
Amino acid residues essential for function of the MexF efflux pump protein of Pseudomonas aeruginosa.
The study identifies critical amino acid residues in the MexF efflux pump of Pseudomonas aeruginosa that are essential for its function in transporting antibiotics such as chloramphenicol, trimethoprim, and fluoroquinolones.
Genes That Enhance the Ecological Fitness of Shewanella oneidensis MR-1 in Sediments Reveal the Value of Antibiotic Resistance
The study identifies mexF as a gene encoding a multidrug resistance pump that is required for resistance to chloramphenicol and tetracycline in Shewanella oneidensis MR-1. Mutations in the TetR family regulatory protein upstream of the mexEF operon were found to increase resistance to chloramphenicol.
Transcriptome profiling defines a novel regulon modulated by the LysR-type transcriptional regulator MexT in Pseudomonas aeruginosa.
The study identifies a novel regulon modulated by the LysR-type transcriptional regulator MexT in Pseudomonas aeruginosa, including genes such as mexT, mexE, mexF, oprN, and mexS. The conserved DNA motif required for MexT-mediated gene activation was identified, and the binding of MexT to this motif was confirmed through EMSA.
The regulatory repertoire of Pseudomonas aeruginosa AmpC ß-lactamase regulator AmpR includes virulence genes.
AmpR is a global regulator in P. aeruginosa that influences the expression of over 500 genes, including those involved in β-lactam resistance, virulence, and biofilm formation.
Transcriptome profiling reveals links between ParS/ParR, MexEF-OprN, and quorum sensing in the regulation of adaptation and virulence in Pseudomonas aeruginosa.
The study identifies that the ParS/ParR system regulates the mexEF-oprN operon through mexS, which is involved in resistance to fluoroquinolones, trimethoprim, and chloramphenicol.
Evolution of Pseudomonas aeruginosa Antimicrobial Resistance and Fitness under Low and High Mutation Rates.
Genomics and Susceptibility Profiles of Extensively Drug-Resistant Pseudomonas aeruginosa Isolates from Spain.
The study identified various AMR genes and mutations in extensively drug-resistant Pseudomonas aeruginosa isolates from Spain, including beta-lactamases, aminoglycoside-modifying enzymes, and mutations in genes such as ampC, oprD, gyrA, parC, mexZ, and glpT, which contribute to resistance against multiple antibiotics.
Manure Application Did Not Enrich Antibiotic Resistance Genes in Root Endophytic Bacterial Microbiota of Cherry Radish Plants.
The study found that manure application increased the occurrence of antibiotic resistance genes (ARGs) in the rhizosphere and phyllosphere of cherry radish, but not in the endophytic bacterial microbiota of the root, which is the edible part of the plant.
Fecal Klebsiella pneumoniae Carriage Is Intermittent and of High Clonal Diversity.
The study identified 25 antibiotic resistance genes in 80 Klebsiella pneumoniae isolates, primarily encoding efflux pumps and inactivating enzymes. Notably, blaSHV, emrB, emrR, marA, marR, msbA, ompK37, oqxA, oqxB, acrA, vgaC, fosA, tet(D), APH(3")-Ib, APH(6)-Id, aadA, qnrS2, rpoB2, mexF, and oprN were found to confer resistance to various antibiotics.
Full pathogen characterisation: species identification including the detection of virulence factors and antibiotic resistance genes via multiplex DNA-assays.
The study presents a DNA microarray-based assay for the simultaneous detection of 44 sepsis-relevant bacterial pathogens, 360 virulence factors, and 409 antibiotic resistance genes. The assay was evaluated with 14 multidrug-resistant strains, including all ESKAPE pathogens.
Antimicrobial Susceptibility Profiles and Resistance Genes in Genus Aeromonas spp. Isolated from the Environment and Rainbow Trout of Two Fish Farms in France.
The study identified several antimicrobial resistance genes in Aeromonas spp. isolated from fish farms, including blaSHV-01, mexF, tetE, floR1, and sul3, which were associated with resistance to beta-lactams, tetracycline, phenicol, and sulfonamide-trimethoprim.
Burkholderiaceae and Multidrug Resistance Genes Are Key Players in Resistome Development in a Germfree Soil Model.
The study identifies multidrug resistance (MDR) genes, particularly multidrug efflux pumps like mexF, as key players in resistome development in a germfree soil model. Burkholderiaceae were found to be the primary carriers of these genes, highlighting their role in antibiotic resistance under tetracycline stress.
Antibiotic resistance in plant growth promoting bacteria: A comprehensive review and future perspectives to mitigate potential gene invasion risks.
This review highlights the prevalence of antibiotic resistance genes (ARGs) in plant growth-promoting bacteria (PGPB) and emphasizes the potential risks of ARG dissemination through biofertilizers. Key findings include the identification of various ARGs such as bacA, fosB, ermD, bl2a, vanSA, cat, acrD, mexF, mexD, mexW, mexE, mexY, mexX, mexZ, mexR, mexA, mexB, mexC, mexD, mexE, and mexF, which confer resistance to multiple antibiotics.
Bacterial diversity and resistome analysis of drinking water stored in cisterns from two First Nations communities in Manitoba, Canada.
The study identified a diverse array of antimicrobial resistance genes in drinking water stored in cisterns from two First Nations communities in Manitoba, Canada. Key findings include the presence of genes such as aac(3')-Ia, aac(6')-Iia, aac(6')-Iic, aph(3')-Ia, acrD, smeB, smeR, FEZ-1, rm3, SPG-1, OXA-21, OXA-119, OXA-205, dfrA14, dfrB6, acrB, acrF, adeF, ceoB, emrA, mexE, mexF, mexI, oprN, oqxB, BRP(MBL), vanSO, axyY, CRP, efrB, macB, mexB, mexC, mexD, mexK, mexQ, mexW, mexY, mtrA, muxB, muxC, oleB, oleC, ompB, oprM, smeD, smeE, golS, mdsB, PER-2, TEM-126, msbA, arnA, bacA, bcrA, MCR-5, rosA, rosB, rpoB2, ugd, mexN, taeA, efpA, rphA, rphB, otr(A), otrC, tetA(48 ), ompH, and triC, which confer resistance to various antibiotics including aminoglycosides, beta-lactams, cephalosporins, carbapenems, fluoroquinolones, macrolides, monobactams, nitroimidazoles, peptides, phenicols, pleuromutilins, rifamycins, tetracyclines, and triclosan.
From Proteome to Potential Drugs: Integration of Subtractive Proteomics and Ensemble Docking for Drug Repurposing against Pseudomonas aeruginosa RND Superfamily Proteins.
The study identifies and characterizes essential proteins in Pseudomonas aeruginosa, particularly RND efflux pumps, which are critical for antibiotic resistance. Computational methods and ensemble docking were used to find potential inhibitors like MK-3207, R-428, and Suramin, showing promise for drug repurposing.
Potential pathogens and antimicrobial resistance genes in household environments: a study of soil floors and cow dung in rural Bangladesh.
The study identified multiple antimicrobial resistance genes (ARGs) in soil floors and cow dung samples from rural Bangladesh, including sul1, tet(Q), ermF, mexF, and cfxA2, which confer resistance to sulfonamides, tetracycline, macrolides, lincosamides, streptogramins, and cephalosporins.
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