mexR
NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
AMR Rules
Browse AMR rules for mexR
Validation StatusCandidate
Overview
- Papers
- 3
- Mutations
- 12
Mutations
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| L57P | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| I72N | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| L75R | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| L75P | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| R83C | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacinaztreonam|carbenicillin|piperacillin-tazobactam|meropenem | Reslit | Candidate |
| T69I | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| R91C | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| L45P | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| R91H | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| I46N | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| L57R | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| V126E | - | - | Pseudomonas aeruginosa | fluoroquinolones | Reslit | Candidate |
Papers3
1
Mutations Affecting DNA-Binding Activity of the MexR Repressor of mexR-mexA-mexB-oprM Operon Expression.
Mutations in mexR lead to derepression of the mexAB-oprM efflux pump, resulting in increased resistance to aztreonam and ofloxacin.
Mutation Information
mexR: p.L57PmexR: p.I72NmexR: p.L75RmexR: p.L75PmexR: p.R83CmexR: p.T69ImexR: p.R91CmexR: p.L45PmexR: p.R91HmexR: p.I46NmexR: p.L57R
- Protein Change
- L57P, I72N, L75R, L75P, R83C, T69I, R91C, L45P, R91H, I46N, L57R
- Organisms
- Pseudomonas aeruginosa
- Confers Resistance To
- aztreonam|ofloxacin
- Source Database
- Reslit
2
Detection of point mutations associated with antibiotic resistance in Pseudomonas aeruginosa.
A novel mutation in codon 126 of mexR is associated with fluoroquinolone resistance.
Mutation Information
- Protein Change
- V126E
- Organisms
- Pseudomonas aeruginosa
- Confers Resistance To
- fluoroquinolones
- Source Database
- Reslit
3
Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.
Mutation Information
- Protein Change
- R83C
- Organisms
- Pseudomonas aeruginosa
- Confers Resistance To
- aztreonam|carbenicillin|piperacillin-tazobactam|meropenem
- Source Database
- Reslit