Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
transcriptional activator
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| D249N | - | - | Pseudomonas aeruginosa | ciprofloxacinnorfloxacinimipenem+1 more | Reslit | Candidate |
| G78S | - | - | - | ciprofloxacin | Reslit | Candidate |
| G123R | - | - | Pseudomonas aeruginosa | imipenemrelebactam | Reslit | Candidate |
| A155V | - | - | - | fluoroquinolones | Reslit | Candidate |
| V73A | - | - | Pseudomonas aeruginosa | ciprofloxacinlevofloxacin | Reslit | Candidate |
| R48C | - | - | - | imipenem | Reslit | Candidate |
| V43G | - | - | Pseudomonas aeruginosa | tobramycinaztreonam | Reslit | Candidate |
| E87K | - | - | Pseudomonas aeruginosa | tobramycinaztreonam | Reslit | Candidate |
| L136Q | - | - | - | meropenem | Reslit | Candidate |
| L409P | - | - | - | meropenem | Reslit | Candidate |
| S567T | - | - | Pseudomonas aeruginosa | ceftazidime avibactamceftolozane tazobactam | Reslit | Candidate |
| G195D | - | - | Pseudomonas aeruginosa | piperacillin tazobactamceftazidimecefepime+4 more | Reslit | Candidate |
Efflux-mediated fluoroquinolone resistance in the multidrug-resistant Pseudomonas aeruginosa clinical isolate PA7: identification of a novel MexS variant involved in upregulation of the mexEF-oprN multidrug efflux operon.
Research Article
The study identified a novel MexS variant (A155V) in Pseudomonas aeruginosa PA7 that leads to upregulation of the mexEF-oprN multidrug efflux operon, contributing to fluoroquinolone resistance. The mutation in mexS was shown to enhance resistance by increasing the expression of the efflux pump.
Amino Acid Substitutions Account for Most MexS Alterations in Clinical nfxC Mutants of Pseudomonas aeruginosa.
Research Article
Mechanisms for Development of Ciprofloxacin Resistance in a Clinical Isolate of Pseudomonas aeruginosa.
Research Article
Low Ciprofloxacin Concentrations Select Multidrug-Resistant Mutants Overproducing Efflux Pumps in Clinical Isolates of Pseudomonas aeruginosa.
Research Article
Low ciprofloxacin concentrations select for multidrug-resistant mutants in Pseudomonas aeruginosa clinical isolates, primarily through overproduction of efflux pumps mexCD-oprJ and mexEF-oprN, along with mutations in gyrA, parE, mexS, and nfxB.
No comments yet. Be the first to comment!