The study shows that the MexXY efflux pump in Pseudomonas aeruginosa is induced by ribosome inhibitors such as tetracycline, chloramphenicol, erythromycin, and spectinomycin. The induction of mexY is dependent on the interaction between the drug and the ribosome, and mutations in ribosomal proteins can affect this induction.

The study identifies several P. aeruginosa genes that are induced during human infections and are associated with antibiotic resistance mechanisms, including efflux pumps, β-lactamases, and other resistance determinants.

The study identifies multiple genes and mutations associated with antibiotic resistance in Pseudomonas aeruginosa through experimental evolution and whole-genome sequencing, highlighting the clinical relevance of these findings.

The study identifies multiple factors contributing to carbapenem resistance in P. aeruginosa JNQH-PA57, including the presence of two chromosomal beta-lactamase genes (blaPDC-12 and blaOXA-488), overexpression of the MexAB-OprM and MexXY-OprM efflux pumps, and a deleted mutation in the mucA gene leading to a mucoid phenotype.

The study identifies the mexY gene as a key component of the MexXY-OprM efflux system, which confers antibiotic resistance in Pseudomonas aeruginosa. Phage-induced mutations and deletions in mexY result in increased antibiotic sensitivity.

The study identifies various genes and mutations associated with resistance to tobramycin, ceftazidime, and ceftazidime-avibactam in Pseudomonas aeruginosa, highlighting the impact of environmental conditions on the evolution of antibiotic resistance.

The study identified mexY as an efflux pump gene involved in P. aeruginosa antibiotic recalcitrance, showing that its expression increases in response to amikacin and decreases with the addition of ferrous.

The study identifies the role of acquired tobramycin resistance mechanisms, including the ant(2")-Ia, aph(3')-IIb, aac(6')-Ib3 genes, and the mexY gene encoding the MexXY-OprM efflux pump, in the transition of Pseudomonas aeruginosa to the viable but non-culturable (VBNC) state.

The study identified multiple antibiotic resistance genes in Pseudomonas aeruginosa isolates from slaughterhouses, including blaCTX-M, blaAmpC, blaSHV, blaNDM, IMP-1, aac(6')-Ib, ant(4')IIb, qnrB, tetA, mexY, TEM, and rmtC. These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, and tetracyclines.

The study reveals that hypermutator strains of P. aeruginosa in CF lungs exhibit increased sensitivity to antimicrobials despite their genetic diversity. Key genes like ampC, mexB, mexY, and norM were found to influence resistance profiles, while mutations in mutS and mutL contributed to hypermutation and altered susceptibility.

The study identified a diverse array of antimicrobial resistance genes in drinking water stored in cisterns from two First Nations communities in Manitoba, Canada. Key findings include the presence of genes such as aac(3')-Ia, aac(6')-Iia, aac(6')-Iic, aph(3')-Ia, acrD, smeB, smeR, FEZ-1, rm3, SPG-1, OXA-21, OXA-119, OXA-205, dfrA14, dfrB6, acrB, acrF, adeF, ceoB, emrA, mexE, mexF, mexI, oprN, oqxB, BRP(MBL), vanSO, axyY, CRP, efrB, macB, mexB, mexC, mexD, mexK, mexQ, mexW, mexY, mtrA, muxB, muxC, oleB, oleC, ompB, oprM, smeD, smeE, golS, mdsB, PER-2, TEM-126, msbA, arnA, bacA, bcrA, MCR-5, rosA, rosB, rpoB2, ugd, mexN, taeA, efpA, rphA, rphB, otr(A), otrC, tetA(48 ), ompH, and triC, which confer resistance to various antibiotics including aminoglycosides, beta-lactams, cephalosporins, carbapenems, fluoroquinolones, macrolides, monobactams, nitroimidazoles, peptides, phenicols, pleuromutilins, rifamycins, tetracyclines, and triclosan.

The study identifies and characterizes essential proteins in Pseudomonas aeruginosa, particularly RND efflux pumps, which are critical for antibiotic resistance. Computational methods and ensemble docking were used to find potential inhibitors like MK-3207, R-428, and Suramin, showing promise for drug repurposing.

The study identified multiple AMR genes, including blaDIM-1, qacE, and various efflux pump genes, in bacterial isolates from hospital disinfectants, indicating their adaptation to survive in disinfectant environments.

The study identifies several beta-lactamase genes, including bla GES-5 and bla OXA-101, as well as other resistance genes such as aadB, aac(6')-Ib4, aph(3')-IIb, and others, contributing to carbapenem resistance in Pseudomonas aeruginosa isolates from Shanghai, China.