Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G46S | - | single resistance variant, abrogate DNA binding, efflux pump transcriptional repressor MexZ | Pseudomonas aeruginosa | AminoglycosideAMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE | Card DatabaseReference Gene CatalogReslit | Confirmed |
| G195E | - | single resistance variant, overexpression of MexXY, strongly impair the dimerization of MexZ and its subsequent binding to the regulatory sequences upstream of mexXY, efflux pump transcriptional repressor MexZ | Pseudomonas aeruginosa | Ciprofloxacin|LevofloxacinCefepime|AminoglycosideAminoglycoside+1 more |
Card DatabaseReference Gene CatalogReslit |
| Confirmed |
| 35fs | - | - | - | Carbapenem | Reslit | Candidate |
| D83E | - | - | Pseudomonas aeruginosa | Cefepime|Gentamicin|Ciprofloxacin | Reslit | Candidate |
| G89S | - | - | Pseudomonas aeruginosa | Gentamicin|Tobramycin | Reslit | Candidate |
| V44A | - | single resistance variant | Pseudomonas aeruginosa | - | Card Database | Established |
| Q10Z | - | single resistance variant | Pseudomonas aeruginosa | - | Card Database | Established |
| P254L | - | - | Pseudomonas aeruginosa | GEN|STR | Reslit | Candidate |
| V136E | - | - | Pseudomonas aeruginosa | GEN|STR | Reslit | Candidate |
| G195D | - | - | Pseudomonas aeruginosa | Piperacillin/tazobactam|Ceftazidime|Cefepime|Imipenem|Meropenem|CiprofloxacinPiperacillin/tazobactam|Ceftazidime|Cefepime|Meropenem|Imipenem|Tobramycin|Ciprofloxacin | Reslit | Candidate |
| F192Y | - | disturb the 3D structure of MexZ | Pseudomonas aeruginosa | Aminoglycoside | Reslit | Candidate |
| A38V | - | disturb the 3D structure of MexZ | Pseudomonas aeruginosa | Aminoglycoside | Reslit | Candidate |
| S198I | - | strongly impair the dimerization of MexZ and its subsequent binding to the regulatory sequences upstream of mexXY | Pseudomonas aeruginosa | Aminoglycoside | Reslit | Candidate |
| L128M | - | disturb the regulatory function of MexZ | Pseudomonas aeruginosa | Aminoglycoside | Reslit | Candidate |
| T32N | - | abrogate DNA binding | Pseudomonas aeruginosa | Aminoglycoside | Reslit | Candidate |
| I16T | - | disturb the 3D structure of MexZ | Pseudomonas aeruginosa | Aminoglycoside | Reslit | Candidate |
| G50D | - | abrogate DNA binding | Pseudomonas aeruginosa | Aminoglycoside | Reslit | Candidate |
| V48A | - | disturb the 3D structure of MexZ | Pseudomonas aeruginosa | Aminoglycoside | Reslit | Candidate |
| G172D | - | strongly impair the dimerization of MexZ and its subsequent binding to the regulatory sequences upstream of mexXY | Pseudomonas aeruginosa | Aminoglycoside | Reslit | Candidate |
| C59Y | - | rigidify the helix locally and abrogate this transmission | Pseudomonas aeruginosa | Aminoglycoside | Reslit | Candidate |
| A144V | - | disturb the 3D structure of MexZ | Pseudomonas aeruginosa | Aminoglycoside | Reslit | Candidate |
| L174Q | - | - | Pseudomonas aeruginosa | Aminoglycoside | Reslit | Candidate |
| L199R | - | - | Pseudomonas aeruginosa | Fluoroquinolones | Reslit | Candidate |
| H345R | - | - | Pseudomonas aeruginosa | Ceftazidime-avibactam|Ceftolozane/tazobactam | Reslit | Candidate |
| E8Ter | - | efflux pump transcriptional repressor MexZ | Pseudomonas aeruginosa | AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE | Reference Gene Catalog | Established |
| Q10Ter | - | efflux pump transcriptional repressor MexZ | Pseudomonas aeruginosa | AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE | Reference Gene Catalog | Established |
| V43A | - | efflux pump transcriptional repressor MexZ | Pseudomonas aeruginosa | AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE | Reference Gene Catalog | Established |
| Q69Ter | - | efflux pump transcriptional repressor MexZ | Pseudomonas aeruginosa | AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE | Reference Gene Catalog | Established |
| Q103Ter | - | efflux pump transcriptional repressor MexZ | Pseudomonas aeruginosa | AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE | Reference Gene Catalog | Established |
| Q134Ter | - | efflux pump transcriptional repressor MexZ | Pseudomonas aeruginosa | AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE | Reference Gene Catalog | Established |
| Q95Ter | - | efflux pump transcriptional repressor MexZ | Pseudomonas aeruginosa | AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE | Reference Gene Catalog | Established |
| W167Ter | - | efflux pump transcriptional repressor MexZ | Pseudomonas aeruginosa | AMINOGLYCOSIDE/CEFEPIME/FLUOROQUINOLONE | Reference Gene Catalog | Established |
| - | - | Pseudomonas aeruginosa | Aminoglycoside|Cefepime|Tetracycline|Macrolide | Reslit | Candidate |
| - | - | Pseudomonas aeruginosa | Tobramycin|Ciprofloxacin | Reslit | Candidate |
| L109F | - | Pseudomonas aeruginosa | Ceftolozane/tazobactam|Piperacillin/tazobactam|Imipenem/relebactam | Reslit | Candidate |
| - | - | Pseudomonas aeruginosa | Fluoroquinolones | Reslit | Candidate |
MexZ-mediated regulation of mexXY multidrug efflux pump expression in Pseudomonas aeruginosa by binding on the mexZ-mexX intergenic DNA.
MexZ; CARD accession: CARD:3003709
Novel Molecular Markers Linked to Pseudomonas aeruginosa Epidemic High-Risk Clones.
associated with high-risk clones
Rapid prediction of carbapenemases in Pseudomonas aeruginosa by imipenem/relebactam and MALDI-TOF MS.
mutations in mexZ contribute to carbapenem resistance
Genetic Diversity of Multidrug-Resistant Pseudomonas aeruginosa Isolates Carrying bla (VIM-2) and bla (KPC-2) Genes That Spread on Different Genetic Environment in Colombia.
Differences in antimicrobial resistance between exoU and exoS isolates of Pseudomonas aeruginosa.
Mutations in mexZ were associated with aminoglycoside resistance.
Deciphering the Resistome of the Widespread Pseudomonas aeruginosa Sequence Type 175 International High-Risk Clone through Whole-Genome Sequencing.
associated with MexXY overexpression
Rapid resistance evolution entails a growth cost
Genomics and Susceptibility Profiles of Extensively Drug-Resistant Pseudomonas aeruginosa Isolates from Spain.
Multiple mutations lead to MexXY-OprM-dependent aminoglycoside resistance in clinical strains of Pseudomonas aeruginosa.
Mutations in mexZ lead to overexpression of mexXY-OprM efflux pump, resulting in aminoglycoside resistance.
mexZ
Characterization of a SPM-1 metallo-beta-lactamase-producing Pseudomonas aeruginosa by comparative genomics and phenotypic analysis.
Mutations in mexZ are often present in clinical isolates overexpressing MexXY.
Keeping up with the pathogens: improved antimicrobial resistance detection and prediction from Pseudomonas aeruginosa genomes.
missense mutation
Molecular characterization of clinically isolated Pseudomonas aeruginosa with varying resistance to ceftazidime-avibactam and ceftolozane-tazobactam collected as a part of the ATLAS global surveillance program from 2020 to 2021.
Monitoring of Pseudomonas aeruginosa mutational resistome dynamics using an enrichment panel for direct sequencing of clinical samples.
Detected in ST175 isolate.
Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa.
mexZ
Clinical strains of Pseudomonas aeruginosa overproducing MexAB-OprM and MexXY efflux pumps simultaneously.
mexZ
[Extraction of nonesterified fatty acids from blood plasma].
mexZ
Exploring the success of Brazilian endemic clone Pseudomonas aeruginosa ST277 and its association with the CRISPR-Cas system type I-C.
Mutations in the efflux pump regulator MexZ shift tissue colonization by Pseudomonas aeruginosa to a state of antibiotic tolerance.
The mutation in mexZ leads to overexpression of the MexXY-OprM efflux pump, which contributes to antibiotic resistance.
Pseudomonas aeruginosa chronic infections in patients with bronchiectasis: a silent reservoir of carbapenemase-producing epidemic high-risk clones.
associated with resistance to β-lactams
Mutation Analysis in Regulator DNA-Binding Regions for Antimicrobial Efflux Pumps in 17,000 Pseudomonas aeruginosa Genomes.
mutations in regulator DNA-binding regions
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