mexxy
multidrug efflux pump
Overview
- Mechanism
- efflux-mediated resistance
- Validation Method
- antibiotic susceptibility tests
- Drug Classes
- aminoglycosides, erythromycin, fluoroquinolones, tigecycline
- Organisms
- Pseudomonas aeruginosa, Pseudomonas aeruginosa PAO1
- Geographic Location
- United Kingdom
- Papers
- 5
- Databases
- Reslit
Multidrug efflux pumps: expression patterns and contribution to antibiotic resistance in Pseudomonas aeruginosa biofilms.
The study identifies the roles of multiple multidrug efflux pumps, including MexAB-OprM, MexCD-OprJ, MexEF-OprN, and MexXY, in the antibiotic resistance of Pseudomonas aeruginosa biofilms.
Gene Information
- Gene Name
- mexxy
- Allele
- mexXY
- Encodes
- multidrug efflux pump
- Source Database
- Reslit
- Confers Resistance To
- aminoglycosideserythromycinfluoroquinolones
- Organisms Tested In
- • Pseudomonas aeruginosa
- Validation Method
- antibiotic susceptibility tests
Efflux-mediated resistance to tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1.
The study identifies mexXY as a gene conferring resistance to tigecycline in Pseudomonas aeruginosa PAO1, and highlights the role of mutations in mexR and nfxB in overexpressing efflux pumps that contribute to resistance.
Gene Information
- Gene Name
- mexxy
- Allele
- mexXY
- Encodes
- efflux pump
- Source Database
- Reslit
- Mechanism
- efflux-mediated resistance
- Confers Resistance To
- tigecycline
- Organisms Tested In
- • Pseudomonas aeruginosa PAO1
- Validation Method
- susceptibility testing
- Sequence Accession
- AY180395
MexXY-OprM Efflux Pump Is Necessary for Adaptive Resistance of Pseudomonas aeruginosa to Aminoglycosides.
The study identifies the MexXY-OprM efflux pump as essential for adaptive resistance of Pseudomonas aeruginosa to aminoglycosides, demonstrating that overproduction of MexY is linked to this resistance mechanism.
Gene Information
- Gene Name
- mexxy
- Allele
- mexXY
- Encodes
- efflux pump system
- Source Database
- Reslit
- Confers Resistance To
- aminoglycosides
- Organisms Tested In
- • Pseudomonas aeruginosa
- Validation Method
- immunoblotting and mutant analysis
Contribution of the MexXY multidrug transporter to aminoglycoside resistance in Pseudomonas aeruginosa clinical isolates.
The study shows that the MexXY multidrug transporter contributes to aminoglycoside resistance in Pseudomonas aeruginosa clinical isolates, as evidenced by the increased susceptibility observed after deletion of mexXY.
Gene Information
- Gene Name
- mexxy
- Allele
- mexXY
- Encodes
- multidrug transporter
- Source Database
- Reslit
- Confers Resistance To
- aminoglycosides
- Organisms Tested In
- • Pseudomonas aeruginosa
- Validation Method
- deletion of mexXY resulted in enhanced susceptibilities to multiple aminoglycosides
A Cystic Fibrosis Epidemic Strain of Pseudomonas aeruginosa Displays Enhanced Virulence and Antimicrobial Resistance.
The study identifies multiple AMR genes and mutations in the Liverpool epidemic strain (LES) of Pseudomonas aeruginosa, including up-regulation of ampC, mexAB-OprM, and mexXY efflux pumps, along with specific mutations in mexR, ampR, ampC, and lasR that contribute to enhanced antimicrobial resistance and virulence.
Gene Information
- Gene Name
- mexxy
- Allele
- mexXY
- Encodes
- efflux pump
- Source Database
- Reslit
- Confers Resistance To
- aminoglycosides
- Organisms Tested In
- • Pseudomonas aeruginosa
- Geographic Location
- United Kingdom
- Validation Method
- up-regulated expression and increased MICs
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