Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
potential protein belonging to the family of pentapeptides
Overview
Intrinsic resistance of Mycobacterium smegmatis to fluoroquinolones may be influenced by new pentapeptide protein MfpA.
The study identifies mfpA as a gene that influences intrinsic resistance to fluoroquinolones in Mycobacterium smegmatis, with increased resistance observed when the gene is expressed on a multicopy plasmid.
Antimicrobial Resistance Mechanisms in Mycobacterium tuberculosis
The paper discusses the molecular mechanisms of drug resistance in Mycobacterium tuberculosis, focusing on genes like pncA, rspA, erm37, tlyA, eis, BlaC, mfpA, IniBAC, EfP, and Tap, which are involved in resistance to pyrazinamide, macrolides, lincosamides, capreomycin, viomycin, kanamycin, β-lactams, fluoroquinolones, isoniazid, ethambutol, and multiple antibiotics.
Antimicrobial Resistance Mechanisms in Mycobacterium tuberculosis
The paper discusses the molecular mechanisms of drug resistance in Mycobacterium tuberculosis, focusing on genes like pncA, rspA, erm37, tlyA, eis, BlaC, mfpA, IniBAC, EfP, and Tap, which are involved in resistance to pyrazinamide, macrolides, lincosamides, capreomycin, viomycin, kanamycin, β-lactams, fluoroquinolones, isoniazid, ethambutol, and multiple antibiotics.
Mycobacterium fluoroquinolone resistance protein B, a novel small GTPase, is involved in the regulation of DNA gyrase and drug resistance.
MfpB, a small GTPase, is required for MfpA-mediated protection of DNA gyrase against fluoroquinolones. MfpB interacts with MfpA and its GTPase activity is crucial for protecting DNA gyrase from drug interference.
Overexpression of mfpA Gene Increases Ciprofloxacin Resistance in Mycobacterium smegmatis.
The study demonstrates that overexpression of the mfpA gene increases ciprofloxacin resistance in Mycobacterium smegmatis, even in strains with pre-existing gyrA mutations.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Recent Advances in Methods to Detect Drug-Resistant Mtb
The paper discusses intrinsic and acquired drug resistance mechanisms in Mycobacterium tuberculosis, highlighting beta-lactamases (blaA, blaC, blaE), erm gene-mediated macrolide/lincosamide/streptogramin B resistance, mfpA-mediated fluoroquinolone/viomycin/capreomycin resistance, and the role of the Eis protein in aminoglycoside resistance. It also identifies mutations in rpoB and gyrA associated with rifampicin and fluoroquinolone resistance.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
A soft-computation hybrid method for search of the antibiotic-resistant gene in Mycobacterium tuberculosis for promising drug target identification and antimycobacterial lead discovery.
The study identified mtrA and katG as potential drug targets in Mycobacterium tuberculosis. Computational analysis suggested that carvacrol, limonene, p-Coumaric acid prenyl ester, 4-aminocinnamic acid, and 4-nitrocinnamic acid could act as inhibitors against these targets.
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