mgrB

regulator

Validation StatusConfirmed2+ DBs

Overview

Mechanism: resistance by absence
Validation Method: PCR and sequencing
Drug Classes: Polymyxin b, COLISTIN, Colistin, Polymyxin, Ceftriaxone, Polymyxin b|Colistin, Tigecycline, Trimethoprim
Organisms: Klebsiella pneumoniae, Escherichia coli str. K-12 substr. MG1655, Escherichia coli, E. coli, Citrobacter werkmanii, Enterobacter cloacae, Staphylococcus aureus, Salmonella enterica
Alleles: 2
Papers: 59
Databases: Card DatabaseReslit
Mutations: 93

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
I45T	-	PhoP/PhoQ regulatory lipoprotein MgrB	Klebsiella pneumoniae	COLISTIN	Reference Gene Catalog	Established
L54H	-	deleterious	Klebsiella pneumoniae	Colistin	Reslit	Candidate
R33Q	-	deleterious	Klebsiella pneumoniae	Colistin

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
mgr B	Reslit	1	Polymyxin b	Klebsiella pneumoniae	-	2021	-	-
mgrB	Card Database	1	-	Escherichia coli str. K-12 substr. MG1655	-	-	NC_000913.3	NP_416340.1