micF

antisense RNA

Validation StatusCandidate

Overview

Mechanism: posttranscriptional negative regulation of ompF
Validation Method: beta-galactosidase assays and outer membrane porin profiling
Drug Classes: Chloramphenicol, Tetracycline, Rifampin
Organisms: Escherichia coli
Papers: 2
Databases: Reslit

Papers2

Activation of multiple antibiotic resistance in uropathogenic Escherichia coli strains by aryloxoalcanoic acid compounds.

PMID 11353631 · 2001

The study identifies that aryloxoalcanoic acid compounds (AOAs) activate multiple antibiotic resistance in uropathogenic Escherichia coli strains by inducing the marRAB operon and repressing the expression of the outer membrane porin OmpF through the micF antisense RNA.

Gene Information

Gene Name: micF
Allele: micF
Encodes: antisense RNA
Source Database: Reslit
Mechanism: posttranscriptional negative regulation of ompF
Confers Resistance To: ChloramphenicolTetracyclineRifampin
Organisms Tested In: • Escherichia coli
Validation Method: beta-galactosidase assays and outer membrane porin profiling

Antibiotic stress, genetic response and altered permeability of E. coli.

PMID 17426813 · 2007

The study identifies several genes involved in the physiological adaptation of E. coli to tetracycline, including marA, soxS, rob, micF, and acrAB, which contribute to the development of multidrug resistance through the upregulation of efflux pumps and downregulation of porins.

Gene Information

Gene Name: micF
Allele: micF
Encodes: post-transcriptional regulator
Source Database: Reslit
Mechanism: down-regulation of porins
Confers Resistance To: Tetracycline
Organisms Tested In: • Escherichia coli
Validation Method: quantitative real-time reverse transcriptase-polymerase chain PCR and western blot detection

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micF

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