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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Membrane-bound lytic murein transglycosylase
Overview
Genetic architecture of intrinsic antibiotic susceptibility.
The study identifies multiple genes and mutations that contribute to antibiotic tolerance in E. coli, revealing a large mutational target size for increasing drug resistance. Key findings include the role of genes involved in electron transport, flagella synthesis, and efflux pumps in modulating susceptibility to various antibiotics.
Changes to its peptidoglycan-remodeling enzyme repertoire modulate β-lactam resistance in Pseudomonas aeruginosa.
The study identifies dacB, sltB1, and mltB as genes whose loss increases β-lactam resistance in Pseudomonas aeruginosa through increased AmpC expression. Conversely, loss of slt and mltF decreases β-lactam resistance.
Loss of membrane-bound lytic transglycosylases increases outer membrane permeability and β-lactam sensitivity in Pseudomonas aeruginosa.
The study identifies that loss of specific lytic transglycosylases (slt, mltB, and sltB1) in Pseudomonas aeruginosa increases β-lactam sensitivity, indicating their role in maintaining outer membrane integrity and reducing antibiotic resistance.
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