Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ResLit

mmpR5

bedaquiline resistance

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to mmpR5

AMR Rules

Browse AMR rules for mmpR5

Validation StatusSupported

Overview

Validation Method: genomic analysis
Drug Classes: Bedaquiline
Organisms: Mycobacterium tuberculosis variant bovis, Mycobacterium tuberculosis, Mycobacterium bovis
Geographic Location: Brazil|Mato Grosso, Philippines
Alleles: 2
Papers: 9
Databases: Reslit
Mutations: 26

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S68G	-	disables its transcriptional repressor function	Mycobacterium tuberculosis, Mycobacterium bovis	Bedaquiline	Reslit	Candidate
46ins	-	-	Mycobacterium tuberculosis	Bedaquiline	Reslit	Candidate
64del	-	-	Mycobacterium tuberculosis	Bedaquiline

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
mmpR5	Reslit	3	Bedaquiline	Mycobacterium tuberculosis variant bovis +1	Brazil\|Mato Grosso, Philippines	2022, 2024, 2025	SRR15649877\|SRR15649878\|SRR15649879\|SRR15649880\|SAMN21018175\|SAMN21018176\|SAMN21018177\|SAMN21018178\|JAIOHE000000000\|JAIOHF000000000\|JAIOHG000000000\|JAIOHH000000000\|ERR3445501\|ERR3445502\|ERR3445503\|ERR3445504\|SRR10997360\|SRR10997362\|SRR10997361\|SRR13046675\|SRR12511761\|SRR9850830	-
MmpR5	Reslit	1	Bedaquiline	Mycobacterium tuberculosis	-	2025	-	-

Papers9

Genomic analysis of Mycobacterium tuberculosis variant bovis strains isolated from bovine in the state of Mato Grosso, Brazil.

PMID 36467663 · 2022

The study identified multiple AMR genes and mutations in Mycobacterium tuberculosis variant bovis strains from Mato Grosso, Brazil, including resistance to pyrazinamide, isoniazid, rifampicin, streptomycin, ethambutol, ethionamide, fluoroquinolones, kanamycin, capreomycin, paraminosalicylic acid, cycloserine, bedaquiline, linezolid, and delamanid.

Gene Information

Gene Name: mmpR5
Allele: mmpR5
Encodes: bedaquiline resistance
Source Database: Reslit
Confers Resistance To: Bedaquiline
Organisms Tested In: • Mycobacterium tuberculosis variant bovis
Geographic Location: Brazil|Mato Grosso
Validation Method: genomic analysis
Sequence Accession: SRR15649877|SRR15649878|SRR15649879|SRR15649880|SAMN21018175|SAMN21018176|SAMN21018177|SAMN21018178|JAIOHE000000000|JAIOHF000000000|JAIOHG000000000|JAIOHH000000000|ERR3445501|ERR3445502|ERR3445503|ERR3445504|SRR10997360|SRR10997362|SRR10997361|SRR13046675|SRR12511761|SRR9850830

Whole genome sequencing analysis of Mycobacterium tuberculosis reveals circulating strain types and drug-resistance mutations in the Philippines.

PMID 39179783 · 2024

The study identifies various AMR genes and mutations in Mycobacterium tuberculosis isolates from the Philippines, including katG, fabG1, rpoB, embB, gyrA, rrs, pncA, inhA, rpsL, mmpR5, and tlyA, which are associated with resistance to isoniazid, rifampicin, ethambutol, fluoroquinolones, streptomycin, pyrazinamide, bedaquiline, and capreomycin.

Gene Information

Gene Name: mmpR5
Allele: mmpR5
Encodes: mycolic acid methyltransferase
Source Database: Reslit
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Philippines
Validation Method: genotypic resistance characterisation using TB-Profiler software
Sequence Accession: AL123456

Speeding up drug susceptibility testing in Mycobacterium tuberculosis using RNA biomarkers.

PMID 40010155 · 2025

The study introduces TRACeR-TB, a rapid drug susceptibility testing method for Mycobacterium tuberculosis that uses RNA biomarkers to detect resistance. It identifies specific mRNA biomarkers for different antibiotics and demonstrates improved sensitivity and specificity compared to traditional methods.

Gene Information

Gene Name: mmpR5
Allele: mmpR5
Encodes: transcriptional repressor of the MmpS5-MmpL5 efflux pump
Source Database: Reslit
Confers Resistance To: Bedaquiline
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: TRACeR-TB assay

Unpacking bedaquiline heteroresistance: the importance of intermediate profiles for phenotypic drug susceptibility testing.

PMID 40689761 · 2025

The study identifies MmpR5 mutations that confer bedaquiline resistance in Mycobacterium tuberculosis, highlighting the importance of intermediate profiles in phenotypic drug susceptibility testing.

Gene Information

Gene Name: mmpR5
Allele: MmpR5
Encodes: transcriptional repressor
Source Database: Reslit
Confers Resistance To: Bedaquiline
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: phenotypic drug susceptibility testing