Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Mph(C) family macrolide 2'-phosphotransferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| mph(C) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 49 | TELITHROMYCIN, ERYTHROMYCIN +6 |
| Switzerland|The Netherlands, United States, China, France|United States, global, Poland, Denmark, Nigeria, Nepal, Pacific region|Hawaii, Korea, Portugal, South Africa, Hawai'i|Hawaiʻi Island, New York State, Spain, Benin, Serbia, Algeria, North America|South America|Europe|Asia|Africa, Egypt, La Rioja, Spain, Japan, Europe, Thailand, Brazil |
| 1998, 2000, 2006, 2007, 2012, 2015, 2016, 2019, 2020, 2021, 2022, 2023, 2024, 2025 |
| AJ251015.1 |
| CAB96926.1 |
| mphC | Reslit | 40 | Macrolide, Erythromycin +2 | Staphylococcus aureus +38 | Kuwait, Germany, London, UK, Delta State, Nigeria, East London|West London, Norway, Kenya, Portugal, South Africa|Nigeria, Novosibirsk, Russia, Europe, Bangladesh|South Africa|Nigeria|Pakistan|Ethiopia|USA|UK, Saudi Arabia, Somalia|Kenya|East Africa, South-eastern Poland, Eastern Switzerland, Bangladesh, Egypt, Malaysia, Algeria, Northwest, China|Northwest China, Swiss Canton Tessin|various herds|Switzerland, Northeast Atlantic Ocean, USA, Europe|Spain, Europe|Africa|North America|South America|Asia|Oceania, Northwestern Transylvania, Romania, Peninsular Malaysia|Malaysia | 2015, 2016, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | ERR387168 | - |
| mphC-msrA | Reslit | 1 | Macrolide | Staphylococcus saprophyticus | Portugal|Spain|Denmark | 2021 | PRJNA604222 | - |
Stenotrophomonas maltophilia D457R contains a cluster of genes from gram-positive bacteria involved in antibiotic and heavy metal resistance.
Presence of new mecA and mph(C) variants conferring antibiotic resistance in Staphylococcus spp. isolated from the skin of horses before and after clinic admission.
The study identifies new variants of the mecA and mph(C) genes in Staphylococcus species isolated from horses, which confer resistance to beta-lactam and macrolide antibiotics, respectively. Additionally, the aac(6')-Ie-aph(2')-Ia gene was found to confer resistance to gentamicin.
Presence of new mecA and mph(C) variants conferring antibiotic resistance in Staphylococcus spp. isolated from the skin of horses before and after clinic admission.
Presence of new mecA and mph(C) variants conferring antibiotic resistance in Staphylococcus spp. isolated from the skin of horses before and after clinic admission.
Presence of new mecA and mph(C) variants conferring antibiotic resistance in Staphylococcus spp. isolated from the skin of horses before and after clinic admission.
Presence of new mecA and mph(C) variants conferring antibiotic resistance in Staphylococcus spp. isolated from the skin of horses before and after clinic admission.
Presence of new mecA and mph(C) variants conferring antibiotic resistance in Staphylococcus spp. isolated from the skin of horses before and after clinic admission.
Resistance phenotypes conferred by macrolide phosphotransferases.
Resistance phenotypes conferred by macrolide phosphotransferases.
Genotypic resistance testing creates new treatment challenges: two cases of oxacillin-susceptible methicillin-resistant Staphylococcus aureus.
Two cases of oxacillin-susceptible methicillin-resistant Staphylococcus aureus (OS-MRSA) were identified, highlighting the importance of genotypic testing for accurate detection of mecA-positive strains despite phenotypic susceptibility to oxacillin.
Macrolide-lincosamide-streptogramin resistance phenotypes and genotypes of coagulase-positive Staphylococcus aureus and coagulase-negative staphylococcal isolates from bovine mastitis.
The study identified various MLS resistance genes, including erm(C), mph(C), erm(B), ere(A), vga(A), lnu(A), and msr(A)/msr(B), in Staphylococcus aureus and coagulase-negative staphylococci isolates from bovine mastitis, highlighting a high prevalence of inducible MLS resistance.
Thirty-minute screening of antibiotic resistance genes in bacterial isolates with minimal sample preparation in static self-dispensing 64 and 384 assay cards.
The study presents a rapid LAMP-based method for detecting antibiotic resistance genes in bacterial isolates with minimal sample preparation, demonstrating successful detection of various resistance genes including aadD, bacA, ble, mepA, norA, qacA, and tetM.
Demography and Intercontinental Spread of the USA300 Community-Acquired Methicillin-Resistant Staphylococcus aureus Lineage.
The study characterizes the AMR genes and mutations in the USA300 CA-MRSA lineage, highlighting the presence of multiple resistance determinants including beta-lactam, aminoglycoside, macrolide, and fluoroquinolone resistance genes, as well as specific mutations in gyrA and parC contributing to fluoroquinolone resistance.
The prevalence of genotypes that determine resistance to macrolides, lincosamides, and streptogramins B compared with spiramycin susceptibility among erythromycin-resistant Staphylococcus epidermidis.
The study identified the prevalence of genes responsible for MLSB resistance in erythromycin-resistant S. epidermidis, highlighting the frequent occurrence of ermC, mphC, msrA, and linA/A'.
Shifts in the Clonal Distribution of Methicillin-Resistant Staphylococcus aureus in Kuwait Hospitals: 1992-2010.
The study identified various AMR genes in MRSA isolates from Kuwait hospitals, including aphA3, aacA-aphD, ermA, ermC, mupA, tetK, tetM, fusC, far1, msrA, mphC, sat, qacA, qacC, merA, merB, dfrS1, aadD, fosB, cat, sdrM, icaA, icaC, and icaD, which conferred resistance to multiple antibiotics.
Characterization of Methicillin-Resistant Staphylococcus aureus Isolated from Healthy Turkeys and Broilers Using DNA Microarrays.
The study identified several AMR genes in MRSA isolates from healthy turkeys and broilers, including ermA, ermB, ermC, tetK, tetM, lnuA, mphC, vgaA, aadD, aphA3, blaZ, blaI, blaR, and mecA. These genes conferred resistance to various antibiotics such as erythromycin, clindamycin, tetracycline, lincomycin, macrolides, streptogramins, tobramycin, neomycin, kanamycin, and beta-lactam antibiotics.
Whole Genome Sequence and Comparative Genomics Analysis of Multi-drug Resistant Environmental Staphylococcus epidermidis ST59.
The study identifies several antibiotic resistance genes in the multidrug-resistant S. epidermidis strain G6_2, including aac(6')-aph(2"), blaZ, mecA, fosB, mphC, msrA, tetK, and qacC, which confer resistance to various antibiotics. Additionally, point mutations in ileS and fusA are associated with resistance to mupirocin and fusidic acid.
Antimicrobial Resistance in Staphylococci of Animal Origin
The paper discusses various antimicrobial resistance genes and mutations in staphylococci of animal origin, highlighting their roles in resistance to multiple antibiotics such as macrolides, lincosamides, streptogramins, oxazolidinones, and others. Key genes include erm, msr, mph, ere, lnu, vga, cfr, optrA, dfr, fus, ileS2, blaZ, aadD, ble, fosD, fosB, czrC, and qac genes, which confer resistance to specific antibiotics and are prevalent in different staphylococcal species.
Antimicrobial Resistance, Virulence Determinants, and Biofilm Formation of Enterococcus Species From Ready-to-Eat Seafood.
The study identified various antimicrobial resistance genes including ermA, ermB, ermC, mphC, vanA, vanB, tetA, and tetM in Enterococcus species isolated from ready-to-eat seafood, indicating the presence of multidrug-resistant strains.
Differences in distribution of MLS antibiotics resistance genes in clinical isolates of staphylococci belonging to species: S. epidermidis, S. hominis, S. haemolyticus, S. simulans and S. warneri.
The study identifies and characterizes MLS B resistance genes, including erm(A), erm(C), lnu(A), msr(A), msr(B), and mph(C), in various coagulase-negative staphylococci species, highlighting their distribution and association with resistance mechanisms.
Whole genome sequencing revealed new molecular characteristics in multidrug resistant staphylococci recovered from high frequency touched surfaces in London.
The study identified several AMR genes in multidrug-resistant staphylococci from high-frequency touched surfaces in London, including blaZ, qacA/B, dfrC, norA, ant(4')-Ib, AAC(6')-Ie-APH(2")-Ia, fusB, msrA, ermC, mphC, tetK, mupA, cat, dfrG, lnuA, fusC, aph3-IIIa, sat4A, vgaA, and others. These genes conferred resistance to various antibiotics such as penicillin, fusidic acid, mupirocin, tetracycline, erythromycin, and chloramphenicol.
Comparative Genomic Analysis of Staphylococcus haemolyticus Reveals Key to Hospital Adaptation and Pathogenicity.
The study identifies several AMR genes and mutations associated with hospital adaptation and pathogenicity in Staphylococcus haemolyticus, highlighting the importance of mecA, aacA-aphD, blaZ, ermC, mphC, qacA, qacB, folP, folB, and sraP in clinical isolates.
Phenotypic and genotypic characterization of clinical Staphylococcus aureus isolates from Kenya.
The study identified multiple antimicrobial resistance genes and mutations in Kenyan Staphylococcus aureus isolates, including mecA, ant(4')-lb, aph(3')-IIIa, ermA, sat-4, fusA, mphC, msrA, gyrA (S84L), parC (S80F), and rpoB mutations, highlighting the presence of multidrug-resistant strains.
Antimicrobial Resistance and Virulence Gene Profiles of Methicillin-Resistant and -Susceptible Staphylococcus aureus From Food Products in Denmark.
The study identified several antimicrobial resistance genes, including blaZ, tet(K), tet(L), tet(M), and various erm genes, in Staphylococcus aureus isolates from food products in Denmark. Additionally, the tst gene was detected in CC398 and CC45 isolates, indicating the presence of toxic shock syndrome toxin.
Genetic Characterization of Methicillin-Resistant Staphylococcus aureus Isolates from Human Bloodstream Infections: Detection of MLS(B) Resistance.
The study identified multiple AMR genes in MRSA isolates from bloodstream infections, including blaZ, ermA, ermC, msrA/B, mphC, aac(6')-Ie-aph(2'')-Ia, and ant(4')-Ia, which conferred resistance to various antibiotics such as beta-lactams, macrolides, lincosamides, streptogramin B, and aminoglycosides.
Antimicrobial Resistance and Virulence of Methicillin-Resistant Staphylococcus aureus from Human, Chicken and Environmental Samples within Live Bird Markets in Three Nigerian Cities.
The study identified various antimicrobial resistance genes in MRSA isolates from human, chicken, and environmental samples in Nigerian live bird markets, highlighting the presence of multidrug-resistant strains and the potential public health risks associated with their dissemination.
Staphylococcus aureus and Methicillin Resistant S. aureus in Nepalese Primates: Resistance to Antimicrobials, Virulence, and Genetic Lineages.
The study identified various antibiotic resistance genes in Staphylococcus aureus isolates from Nepalese primates, including erm(C), aacA-aphD, blaZ, msr(A), and mph(C). These genes conferred resistance to multiple antibiotics such as erythromycin, clindamycin, gentamicin, penicillin, and others.
A Longitudinal Evaluation of the Bacterial Pathogens Colonizing Chronic Non-Healing Wound Sites at a United States Military Treatment Facility in the Pacific Region.
The study identified multiple antimicrobial resistance genes in bacterial isolates from chronic non-healing wounds, including beta-lactamases, aminoglycoside modifying enzymes, macrolide resistance genes, and others. These genes were found in various bacterial species such as E. coli, S. aureus, P. aeruginosa, and others.
Genome-Wide Analysis of Staphylococcus aureus Sequence Type 72 Isolates Provides Insights Into Resistance Against Antimicrobial Agents and Virulence Potential.
The study identified several AMR genes in ST72 isolates, including blaZ, aadD, ermC, msr(A), mph(C), tetK, aac(6')-aph(2'), fusC, and dfrG, which confer resistance to various antibiotics. K07-204 showed resistance to methicillin, ampicillin, erythromycin, kanamycin, and tetracycline, while K07-561 exhibited resistance to ampicillin and tetracycline. Additionally, K07-204 was found to be highly resistant to lysostaphin.
Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections.
The study identified antimicrobial resistance genes qacA, dfrG, and qacC in Staphylococcus saprophyticus isolates, highlighting their role in resistance to quaternary ammonium compounds, trimethoprim, and biocides respectively.
Clonal Lineages, Antimicrobial Resistance, and PVL Carriage of Staphylococcus aureus Associated to Skin and Soft-Tissue Infections from Ambulatory Patients in Portugal.
The study identified various AMR genes and mutations in S. aureus isolates from SSTIs in ambulatory patients in Portugal, including blaZ, mecA, erm(A), erm(C), msr(A), mph(C), aadD, aacA-aphD, aph(3')-IIIa, and fusC, along with mutations in grlA, gyrA, and fusA associated with fluoroquinolone and fusidic acid resistance.
Analysis of Genome Sequences of Coagulase-Negative Staphylococci Isolates from South Africa and Nigeria Highlighted Environmentally Driven Heterogeneity.
The study identified several AMR genes in coagulase-negative staphylococci isolates from South Africa and Nigeria, highlighting environmentally driven heterogeneity. Notably, the tetM gene was found in South African isolates but not in Nigerian ones, while cadmium resistance genes were present in Nigerian isolates. Other genes like blaZ, FosB, mecA, FusF, dfrG, ErmA, ErmB, Erm(43), and mphC were also characterized.
Genomic Analysis of Antibiotic-Resistant Staphylococcus epidermidis Isolates From Clinical Sources in the Kwazulu-Natal Province, South Africa.
The study identified multiple antibiotic resistance genes in methicillin-resistant Staphylococcus epidermidis isolates, including mecA, blaZ, tet(K), erm(A), erm(B), erm(C), dfrG, aac(6')-aph(2''), and cat(pC221), which confer resistance to beta-lactams, tetracyclines, macrolides, lincosamides, streptogramin B, trimethoprim, aminoglycosides, and chloramphenicol.
Environmental Surveillance and Characterization of Antibiotic Resistant Staphylococcus aureus at Coastal Beaches and Rivers on the Island of Hawai'i.
The study identified various antibiotic resistance genes in Staphylococcus aureus isolates from coastal beaches and rivers on the island of Hawai'i, highlighting the presence of multidrug-resistant strains.
Distribution and Clonal Diversity of Staphylococcus aureus and Other Staphylococci in Surface Waters: Detection of ST425-t742 and ST130-t843 mecC-Positive MRSA Strains.
The study identified mecC-positive MRSA strains ST425-t742 and ST130-t843 in surface waters, along with various AMR genes such as mecC, blaZ, ermT, msr(A/B), vgaA, tetL, mecA, mph(C), aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, dfrA, fusB, and catpC221 in Staphylococcus aureus and coagulase-negative staphylococci.
Antibiotic Resistance and Pathogenomics of Staphylococci Circulating in Novosibirsk, Russia.
The study identified several AMR genes in Staphylococcus isolates from Novosibirsk, Russia, including mecA, blaZ, aac(6')-Ie-aph(2'')-Ia, ant(4')-Ia, aph(3')-IIIa, ermA, ermC, msrA, norA, dfrC, fosB, and mphC, which confer resistance to beta-lactams, aminoglycosides, macrolides, quinolones, and other antibiotics.
Whole Genome Sequencing of Staphylococci Isolated From Bovine Milk Samples.
The study identified several antimicrobial resistance genes in non-aureus staphylococci (NAS) and Staphylococcus aureus, including lnuA, blaZ, ermA, ermB, ermC, mphC, msrA, aadD, aac-aph, str, and norA. These genes conferred resistance to lincomycin, penicillin, macrolides, aminoglycosides, and multiple antibiotics.
Multidrug-Resistant Methicillin-Resistant Coagulase-Negative Staphylococci in Healthy Poultry Slaughtered for Human Consumption.
The study identified multiple multidrug-resistant methicillin-resistant coagulase-negative staphylococci (MRCoNS) in poultry, carrying genes such as mecA, ermA, ermB, ermC, mphC, aph(3')-IIIa, ant(4')-Ia, str, tetK, tetL, tetM, tetO, cfr, dfrK, dfrD, and cat p194, which confer resistance to various antibiotics.
The Emergence of a Multidrug-Resistant and Pathogenic ST42 Lineage of Staphylococcus haemolyticus from a Hospital in China.
The study identifies the ST42 lineage of Staphylococcus haemolyticus as a multidrug-resistant and pathogenic clone with a high burden of antibiotic resistance genes (ARGs) and virulence determinants.
Antimicrobial Resistance and Clonal Lineages of Staphylococcus aureus from Cattle, Their Handlers, and Their Surroundings: A Cross-Sectional Study from the One Health Perspective.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from cattle, farm workers, and their environment, highlighting the potential for transmission between hosts and the need for monitoring AMR in One Health contexts.
Antimicrobial resistance and virulence factors in Staphylococcus aureus and other Gram-positive bacteria causing neonatal sepsis in low-resource settings
The study identifies various antimicrobial resistance genes in Staphylococcus aureus and other Gram-positive bacteria causing neonatal sepsis, including mecA, tet(K), tet(M), tet(L), aadD, aph(3)-III, ermA, ermC, msrA, mphC, and IS256. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in low-resource settings.
Methicillin Resistant Staphylococci Isolated from Goats and Their Farm Environments in Saudi Arabia Genotypically Linked to Known Human Clinical Isolates: a Pilot Study.
The study identified several AMR genes in methicillin-resistant staphylococci isolates from goats and their farm environments in Saudi Arabia, including mecA, blaZ, norA, lmrS, mepA, mepR, arlR, arlS, tet(38), mecR1, dfrC, fusC, fosB, fexA, tetM, msrA, mphC, fusB, APH(3′)-IIIa, tetK, and dfrG. These genes confer resistance to various antibiotics such as penicillins, fluoroquinolones, aminoglycosides, macrolides, phenicols, diaminopyrimidines, oxazolidinones, tetracyclines, and fosfomycin.
Genomic Characterization and Antimicrobial Susceptibility of Dromedary-Associated Staphylococcaceae from the Horn of Africa.
The study identified several antimicrobial resistance genes in Staphylococcaceae isolates from camels and cattle in East Africa, including tet(K), blaZ, blaARL, mecA, mecA1, msrA, mphC, salA, dfrG, aacA-aphD, and str. These genes were associated with resistance to tetracycline, benzylpenicillin, oxacillin, erythromycin, clindamycin, trimethoprim, gentamicin, and streptomycin.
Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus.
The paper discusses the molecular mechanisms of resistance to non-beta-lactam antibiotics in Staphylococcus aureus, highlighting the roles of various genes and mutations in conferring resistance to macrolides, lincosamides, aminoglycosides, glycopeptides, oxazolidinones, lipopeptides, fluoroquinolones, and other antibiotics.
Antimicrobial Resistance and Virulence Genes in Staphylococci Isolated from Aviary Capercaillies and Free-living Birds in South-eastern Poland.
The study identified several AMR genes in Staphylococcus isolates from birds, including mecA, blaZ, msrA/B, ermC, mphC, tetK, tetM, cfr, norA, aac(6')-aph(2"), sea, and tst. These genes conferred resistance to various antibiotics such as methicillin, beta-lactams, macrolides, tetracyclines, chloramphenicol, florfenicol, fluoroquinolones, and aminoglycosides.
Outbreak investigation including molecular characterization of community associated methicillin-resistant Staphylococcus aureus in a primary and secondary school in Eastern Switzerland.
The study identified a cluster of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in a school in Eastern Switzerland, characterized by ST5 sequence type and efflux-mediated macrolide resistance. The outbreak was linked to a local school, and decolonization efforts successfully reduced the incidence of CA-MRSA cases.
A multicentre study reveals dysbiosis in the microbial co-infection and antimicrobial resistance gene profile in the nasopharynx of COVID-19 patients.
The study identified a variety of antimicrobial resistance genes in the nasopharynx of COVID-19 patients, including beta-lactamases, macrolide-lincosamide-streptogramin resistance genes, tetracycline resistance genes, and others. These genes were found to be prevalent in both symptomatic and asymptomatic patients, highlighting the importance of monitoring antimicrobial resistance in the context of the pandemic.
Genomic Analysis of Vancomycin-Resistant Staphylococcus aureus Isolates from the 3rd Case Identified in the United States Reveals Chromosomal Integration of the vanA Locus.
The study identifies the chromosomal integration of the vanA locus in vancomycin-resistant Staphylococcus aureus (VRSA) isolates, highlighting the role of plasmid pWC79 in multidrug resistance and the genetic mechanisms behind the emergence of VRSA.
Clinical Resistant Strains of Enterococci and Their Correlation to Reduced Susceptibility to Biocides: Phenotypic and Genotypic Analysis of Macrolides, Lincosamides, and Streptogramins.
The study identified various AMR genes associated with resistance to macrolides, lincosamides, and streptogramins in Enterococci, including ermB, ermA, ermC, ereA, lnuA, mphC, mefA, and mefE. These genes were found to be highly prevalent and contribute to the resistance mechanisms observed in the isolates.
Inhibition of Erythromycin and Erythromycin-Induced Resistance among Staphylococcus aureus Clinical Isolates.
The study identified several AMR genes associated with erythromycin and clindamycin resistance in Staphylococcus aureus, including ermC, ermA, ermB, msrA, msrB, lnuA, and mphC. These genes were detected through PCR and phenotypic analysis.
Complete Genome Sequence and Analysis of a ST573 Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus SauR3 Clinical Isolate from Terengganu, Malaysia.
The study identifies multiple antimicrobial resistance genes in the multidrug-resistant S. aureus isolate SauR3, including blaZ, mecA, norA, norC, sdrM, ermC, lmrS, msrA, mphC, aph(3′)-IIIa, aadE, aac(6′)Ie-aph(2″)Ia, fosB, and SAT-4, contributing to resistance against various antibiotics.
Prevalence and Molecular Characterization of Methicillin-Resistant Staphylococcaceae (MRS) and Mammaliicocci (MRM) in Dromedary Camels from Algeria: First Detection of SCCmec-mecC Hybrid in Methicillin-Resistant Mammaliicoccus lentus.
The study identified methicillin-resistant Staphylococcus and Mammaliicoccus species in dromedary camels in Algeria, including the first detection of a SCCmec-mecC hybrid in Mammaliicoccus lentus. Key resistance genes identified include mecA, mecC, blaZ, aadD, dfrG, ermB, ermA, msrA, mphC, fosB, fusB, and tet(K).
Molecular epidemiology and characterization of antimicrobial-resistant Staphylococcus haemolyticus strains isolated from dairy cattle milk in Northwest, China.
The study identified several antimicrobial resistance genes in Staphylococcus haemolyticus strains isolated from dairy cattle milk in Northwest, China, including mphC, ermB, floR, aadD, sul1, and gyrA, which confer resistance to erythromycin, florfenicol, gentamicin, trimethoprim-sulfamethoxazole, and ciprofloxacin.
Occurrence, Antibiotic Susceptibility, Biofilm Formation and Molecular Characterization of Staphylococcus aureus Isolated from Raw Shrimp in China.
The study identified multiple antibiotic resistance genes in Staphylococcus aureus isolates from raw shrimp in China, including mecA, mecR1, blaZ, aph(3')-IIIa, aad(6), ANT(4')-Ib, tet(K), mph(C), lnu(A), ermB, ermC, dfrC, dfrG, fosB, SAT-4, rpoB, msr(A), mepA, mepR, norA, mgrA, tet(38), sav1866, arlR, and arlS, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, macrolides, lincosamides, streptogramins, trimethoprim, fosfomycin, and others.
Antibiotic Resistance/Susceptibility Profiles of Staphylococcus equorum Strains from Cheese, and Genome Analysis for Antibiotic Resistance Genes.
The study identified several antibiotic resistance genes in Staphylococcus equorum strains from cheese, including blaR1-blaZI, bla, mph(C), msr(A), norA, fosB/fosD, and cat, which confer resistance to various antibiotics such as beta-lactams, macrolides, fluoroquinolones, fosfomycin, and chloramphenicol.
Elucidation of the Bovine Intramammary Bacteriome and Resistome from healthy cows of Swiss dairy farms in the Canton Tessin.
The study identified the presence of the tetracycline resistance gene tetK in Mammaliicoccus sciuri isolates, which was associated with tetracycline resistance. The gene was found on small plasmids, suggesting a potential mechanism for horizontal gene transfer.
Whole-Genome Sequencing-Based Screening of MRSA in Patients and Healthcare Workers in Public Hospitals in Benin.
The study identified multiple AMR genes and mutations in MRSA isolates from Benin, including mecA, aac(6')-Ie/aph(2")-Ia, aph(3')-IIIa, blaI, blaR1, blaZ, mecI, mecR1, fosB, erm(C), mph(C), msr(A), qacC, dfrG, and dfrS1, along with mutations in glpT, murA, gyrA, and parC associated with resistance to various antibiotics.
An increase in erythromycin resistance in methicillin-susceptible Staphylococcus aureus from blood correlates with the use of macrolide/lincosamide/streptogramin antibiotics. EARS-Net Spain (2004-2020).
The study identifies erm(C), erm(A), erm(T), msr(A), and mph(C) as key genes contributing to erythromycin resistance in methicillin-susceptible Staphylococcus aureus (MSSA) isolates in Spain, with a notable increase in erm(T) prevalence post-2013.
A Staphylococcus capitis strain with unusual bacteriocin production.
The study identifies two distinct biosynthetic gene clusters in Staphylococcus capitis BN2: one encoding the lantibiotic gallidermin and another encoding a novel non-ribosomal peptide synthetase (NRPS) gene cluster. These clusters contribute to the strain's ability to inhibit the growth of methicillin-resistant and vancomycin-intermediate Staphylococcus aureus strains.
Genomic Insights into Methicillin-Resistant Staphylococci and Mammaliicocci from Bulk Tank Milk of Dairy Farms in Serbia.
The study identified multiple AMR genes in methicillin-resistant staphylococci and mammaliicocci from bulk tank milk, highlighting their role as potential reservoirs of antimicrobial resistance genes.
Antimicrobial Resistance Genes in Staphylococcus Species Isolated from Diabetic Foot Ulcers and Healthy Skin
The study identified various antimicrobial resistance genes in Staphylococcus species isolated from diabetic foot ulcers and healthy skin, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, macrolides, tetracyclines, fusidic acid, trimethoprim-sulfamethoxazole, fosfomycin, kanamycin, neomycin, and quaternary ammonium compounds.
Comparative genomics reveals the correlations of stress response genes and bacteriophages in developing antibiotic resistance of Staphylococcus saprophyticus.
The study identifies several AMR genes in Staphylococcus saprophyticus, including mecA, blaZ, erm, erm(44)v, msr(A), and mph(C), which confer resistance to beta-lactams, macrolides, and lincosamides. The presence of these genes is associated with varying levels of resistance, and some genes, like mecA, are useful markers for predicting resistance to specific antibiotics.
Antibiotic Resistance Genes, Virulence Factors, and Biofilm Formation in Coagulase-Negative Staphylococcus spp. Isolates from European Hakes (Merluccius merluccius, L.) Caught in the Northeast Atlantic Ocean.
The study identifies multiple antibiotic resistance genes in coagulase-negative staphylococci (CoNS) isolated from European hakes, including blaZ, mphC, msr(A/B), lnuA, vgaA, fusB, and dfrA, which confer resistance to penicillin, macrolides/lincosamides, fusidic acid, and trimethoprim-sulfamethoxazole. These CoNS isolates also carry virulence factors such as scn and hla.
Genetic diversity of macrolides resistant Staphylococcus aureus clinical isolates and the potential synergistic effect of vitamins, C and K(3).
The study identified several macrolide resistance genes, including erm(A), erm(B), erm(C), msr(A), and mph(C), in Staphylococcus aureus isolates. These genes were associated with resistance to erythromycin and azithromycin.
Comparative genomic analysis of antibiotic resistance and virulence genes in Staphylococcus aureus isolates from patients and retail meat.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from both patients and retail meat, including blaZ, fosB-Saur, tet38, mphC, msrA, sat4, mecA, aph(3')-IIIa, and fusC. These genes were associated with resistance to various antibiotics such as penicillin, tetracycline, macrolides, and fusidic acid.
Characterization of the resistome and predominant genetic lineages of Gram-positive bacteria causing keratitis.
The study characterizes the resistome of Gram-positive bacteria causing keratitis, identifying several AMR genes and mutations associated with resistance to antibiotics such as macrolides, aminoglycosides, tetracyclines, and fluoroquinolones. Key findings include the prevalence of ermA, ermB, ermC, mphC, msrA, msrD, mecA, ant(9)-Ia, ant(4′)-Ib, aac(6′)-aph(2″), aph(3′)-III, fosB, tetK, tetM, dfrG, dfrC, and dfrE genes, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
Genetic Diversification and Resistome of Coagulase-Negative Staphylococci from Nostrils of Healthy Dogs and Dog-Owners in La Rioja, Spain.
The study identified various AMR genes including blaZ, mecA, erm(A), erm(C), erm(T), mph(C), msr(A), vga(A), lsaB, ant4′, aac6′-aph2″, tet(K), tet(M), dfrA, dfrG, catPC221, and mupA in CoNS isolates from healthy dogs and dog-owners. Additionally, a linezolid-resistant S. epidermidis isolate was found to have multiple amino acid substitutions in 50S ribosomal proteins L3 and L4.
Microbial adaptation to spaceflight is correlated with bacteriophage-encoded functions.
The study identifies prophage-encoded antibiotic resistance genes, including aadK in Paenibacillus polymyxa and mph(C) and msr(A) in Staphylococcus epidermidis, highlighting the role of bacteriophages in microbial adaptation to spaceflight.
Methicillin-resistant Staphylococcus aureus and coagulase-negative Staphylococcus produce antimicrobial substances against members of the skin microbiota in children with atopic dermatitis.
The study identified two bacteriocin gene clusters, aureocin 4181 in MRSA 23ad and epidermicin NI01 in S. epidermidis 84ad, which are involved in the production of antimicrobial substances that inhibit the growth of other staphylococcal species.
Genomic analysis of Staphylococcus aureus isolates from bacteremia reveals genetic features associated with the COVID-19 pandemic.
The study identifies several antibiotic resistance genes and mutations in Staphylococcus aureus isolates associated with increased resistance to methicillin, macrolides, and other antibiotics during the COVID-19 pandemic.
Detection and genetic characterization of multidrug-resistant staphylococci isolated from public areas in an international airport.
The study identified multiple multidrug-resistant staphylococci, including methicillin-resistant S. haemolyticus, S. epidermidis, and a livestock-associated MRSA (LA-MRSA) strain, carrying various resistance genes such as mecA, blaZ, erm(C), aac(6')-aph(2''), and others, highlighting the presence of AMR in public environments.
Microbial spectrum and resistance of odontogenic abscesses - microbiological analysis using next generation sequencing.
The study identified multiple AMR genes in odontogenic abscesses using NGS, including genes conferring resistance to tetracyclines, macrolides, lincosamides, aminoglycosides, chloramphenicol, sulfonamides, penicillins, and others. Notably, Fusobacterium showed resistance to clindamycin.
The prevalence of multidrug resistance in Staphylococcus hominis isolated from clinical materials.
The study identified several AMR genes in Staphylococcus hominis, including erm(C), tetK, acc(6')-Ie aph(2''), aph(3')-IIIa, ant(4')-Ia, msr(B), mph(C), lnu(A), and vga, which confer resistance to various antibiotics such as macrolides, lincosamides, streptogramins, tetracyclines, and aminoglycosides. The majority of the strains exhibited multidrug resistance.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Mapping Antimicrobial Resistance in Staphylococcus epidermidis Isolates from Subclinical Mastitis in Danish Dairy Cows.
The study identified several antimicrobial resistance genes in Staphylococcus epidermidis isolates from subclinical mastitis in Danish dairy cows, including blaZ for penicillin resistance, fosB for fosfomycin resistance, msr(A) and mph(C) for erythromycin resistance, and tet(K) for tetracycline resistance.
The Difference a Year Can Make: How Antibiotic Resistance Mechanisms in Pseudomonas aeruginosa Have Changed in Northwestern Transylvania.
The study identified an increase in multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa isolates in Northwestern Transylvania, Romania, between 2022 and 2023. Key AMR genes included bla OXA-50, sul1, ermB, mexA, mexB, bla VIM-1, aac(6′)-II, ant(4′)-Ia, aac(3)-I, aac(6′)-Im, aph(2″)-Ib, tetA, tetC, tetK, qnrB, ermC, mphC, fosA, nfsA, nfsB, ampC, and TEM-1.
Bats as Hosts of Antimicrobial-Resistant Mammaliicoccus lentus and Staphylococcus epidermidis with Zoonotic Relevance.
The study identified antimicrobial resistance genes in Mammaliicoccus lentus and Staphylococcus epidermidis isolated from bats, including mph(C), msr(A), dfrC, salB, tet(K), str, qacA, arsB, and cadD, highlighting their potential for horizontal gene transfer and environmental co-selection.
Phylogenomic associations among methicillin-resistant Staphylococcus aureus isolates derived from pets, dairies, and humans.
The study identified several AMR genes in methicillin-resistant Staphylococcus aureus (MRSA) isolates from pets, dairies, and humans, including mecA, tet(M), tet(K), erm(C), erm(A), mph(C), msr(A), blaR1, blaZ, blaI_of_Z, blaPC1, vga(A), fosB-Saur, sat4, bleO, ant(9)-Ia, aph(2'')-Ih, aph(3')-IIIa, and ant(4')-Ia. These genes confer resistance to various antibiotics such as methicillin, tetracycline, erythromycin, macrolides, lincomycin, fosfomycin, streptothricin, bleomycin, spectinomycin, amikacin, gentamicin, kanamycin, tobramycin, and others.
Phenotypic and genotypic characteristics of macrolide, lacosamide, and streptogramin resistance in clinically resistant Streptococci and their correlation with reduced biocide susceptibility.
The study identifies ermB, ereA, msrA, mefA, and mefE as key genes associated with MLS resistance in Streptococci, highlighting the role of efflux mechanisms and ribosomal methylation in conferring resistance to macrolides, lincosamides, and streptogramins.
Genomic characterisation of nasal isolates of coagulase-negative Staphylococci from healthy medical students reveals novel Staphylococcal cassette chromosome mec elements.
The study identified novel Staphylococcal cassette chromosome mec (SCC mec ) elements in four methicillin-resistant coagulase-negative Staphylococci (CoNS) isolates from healthy medical students. The isolates harbored various antimicrobial resistance genes, including mecA, blaZ, mphC, msrA, tetK, fusC, fusF, qacA, qacB, qacC, norA, copB, arsC, cadC, cadD, copZ, copA, copR, and czcD, which conferred resistance to beta-lactams, macrolides, tetracyclines, fusidic acid, quaternary ammonium compounds, fluoroquinolones, and heavy metals.
Breastfeeding and early Bifidobacterium-driven microbial colonization shape the infant gut resistome.
Exclusive breastfeeding reduces antimicrobial resistance gene burden in infants by promoting Bifidobacterium, counteracting C-section and antibiotic effects, and supporting healthy gut microbiome development during early life.
Prevalence and antimicrobial resistance of methicillin-resistant and methicillin-susceptible Staphylococcus in small- to medium-scale and large-scale dairy farms in Thailand.
The study identified several AMR genes and mutations in Staphylococcus isolates from small- to medium-scale and large-scale dairy farms in Thailand, highlighting differences in resistance profiles between farm types.
Whole genome sequence of multidrug-resistant Staphylococcus haemolyticus and Enterococcus faecalis isolates from public gymnasium equipment reveals evolving infection potential and resistance.
The study identified multiple antibiotic resistance genes in multidrug-resistant Staphylococcus haemolyticus and Enterococcus faecalis isolates from public gymnasium equipment, highlighting their potential to resist various antibiotics and posing a health risk in communal environments.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
High colonization by multidrug-resistant and virulent Staphylococcus aureus genotypes among critically ill patients in the COVID-19 pandemic in a Brazilian hospital.
The study identified multiple AMR genes in MRSA isolates from critically ill patients during the COVID-19 pandemic, including erm(C), msr(A), mph(C), smr, aph(3')-III3a, and various virulence genes such as sasG, ebpS, scn, egc_cluster, fnbpB, cna, and pvl.
Genomic Insights into Multidrug-resistant Mammaliicoccus sciuri Carrying Novel Staphylococcal Cassette Chromosome mec (SCCmec) Elements and Plasmids from Farm Ruminants on the East Coast of Peninsular Malaysia.
The study identified multiple antimicrobial resistance genes in four multidrug-resistant Mammaliicoccus sciuri isolates from farm ruminants in Peninsular Malaysia, including mecA, ermY, mphC, msrA, tetL, tetS, aadD, ant(6)-Ia, aac(6')-Ie-aph(2")-Ia, fexA, icaA, icaB, icaC, icaD, icaR, sspA, ndk, and lgt. These genes confer resistance to various antibiotics, including β-lactams, macrolides, tetracyclines, aminoglycosides, and chloramphenicol.
A plasmid that encodes three genes for resistance to macrolide antibiotics in Staphylococcus aureus.
A plasmid that encodes three genes for resistance to macrolide antibiotics in Staphylococcus aureus.
A plasmid that encodes three genes for resistance to macrolide antibiotics in Staphylococcus aureus.
A plasmid that encodes three genes for resistance to macrolide antibiotics in Staphylococcus aureus., Presence of new mecA and mph(C) variants conferring antibiotic resistance in Staphylococcus spp. isolated from the skin of horses before and after clinic admission.
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