Browse AMR Genes

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mphJ

macrolide 2'-phosphotransferase MphJ

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to mphJ

Browse AMR rules for mphJ

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic inactivation
Drug Classes: TELITHROMYCIN, ERYTHROMYCIN, TYLOSIN, MACROLIDE ANTIBIOTIC
Organisms: Brevibacillus brevis Vm4
Alleles: 3
Papers: 1
Databases: Card DatabaseReference Gene CatalogResFinder Database

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
MphJ	Card DatabaseReference Gene CatalogResFinder Database	3	TELITHROMYCIN, ERYTHROMYCIN +1	Brevibacillus brevis Vm4	-	2018	KY753883.1	ATL63232.1
mph(J)	ResFinder Database	1	ERYTHROMYCIN, TYLOSIN	Brevibacillus brevis Vm4	-	2018	KY753883	-
mphJ	Card Database	1	MACROLIDE ANTIBIOTIC	Brevibacillus brevis Vm4	-	-	KY753883.1	ATL63232.1

Papers1

1

The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies.

PMID 29259290 · 2018

Gene Information

Gene Name: mphJ
Allele: MphJ
Encodes: macrolide 2'-phosphotransferase MphJ
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TELITHROMYCINERYTHROMYCINTYLOSIN
Organisms Tested In: • Brevibacillus brevis Vm4
Sequence Accession: KY753883.1
Protein Accession: ATL63232.1
Notes: Macrolide phosphotransferase

2

The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies.

PMID 29259290 · 2018

Gene Information

Gene Name: mphJ
Allele: MphJ
Encodes: macrolide 2'-phosphotransferase MphJ
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TELITHROMYCINERYTHROMYCINTYLOSIN
Organisms Tested In: • Brevibacillus brevis Vm4
Sequence Accession: KY753883.1
Protein Accession: ATL63232.1
Notes: Macrolide phosphotransferase

3

The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies.

PMID 29259290 · 2018

Gene Information

Gene Name: mphJ
Allele: MphJ
Encodes: macrolide 2'-phosphotransferase MphJ
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TELITHROMYCINERYTHROMYCINTYLOSIN
Organisms Tested In: • Brevibacillus brevis Vm4
Sequence Accession: KY753883.1
Protein Accession: ATL63232.1
Notes: Macrolide phosphotransferase

4

The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies.

PMID 29259290 · 2018

Gene Information

Gene Name: mphJ
Allele: mph(J)
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: ERYTHROMYCINTYLOSIN
Organisms Tested In: • Brevibacillus brevis Vm4
Sequence Accession: KY753883
Notes: Macrolide phosphotransferase

5

Gene Information

Gene Name: mphJ
Allele: mphJ
Encodes: macrolide phosphotransferase (MPH)
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: MACROLIDE ANTIBIOTIC
Organisms Tested In: • Brevibacillus brevis Vm4
Sequence Accession: KY753883.1
Protein Accession: ATL63232.1
Notes: ARO:3004544

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