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mpl

UDP-MurNAc-l-Ala-d-Glu-meso-diaminopimelate ligase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to mpl

Browse AMR rules for mpl

Validation StatusSupported

Overview

Mechanism: peptidoglycan synthesis
Validation Method: transposon insertion and MIC testing
Drug Classes: Ampicillin, Piperacillin, Ceftazidime, Imipenem, Vancomycin, Cefepime, Ceftazidime|Piperacillin/tazobactam, Cephalosporin|Penicillin, Aztreonam, Meropenem
Organisms: Acinetobacter baylyi, Pseudomonas aeruginosa
Geographic Location: Asia/South Pacific|Europe|Latin America|Middle East/Africa|North America, Europe
Papers: 7
Databases: Reslit
Mutations: 7

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
R333H	-	-	Pseudomonas aeruginosa	Ceftazidime\|Piperacillin/tazobactam	Reslit	Candidate
T236P	-	-	-	Ceftazidime	Reslit	Candidate
Y35S	-	-	-	Ceftazidime	Reslit

Papers7

1

Genes involved in intrinsic antibiotic resistance of Acinetobacter baylyi.

PMID 16940057 · 2006

The study identifies 11 genes in Acinetobacter baylyi whose disruption leads to antibiotic hypersusceptibility, including genes involved in efflux pumps, peptidoglycan synthesis, and other metabolic pathways.

Gene Information

Gene Name: mpl
Allele: mpl
Encodes: UDP-MurNAc-l-Ala-d-Glu-meso-diaminopimelate ligase
Source Database: Reslit
Mechanism: peptidoglycan synthesis
Confers Resistance To: AmpicillinPiperacillinCeftazidimeImipenemVancomycin
Organisms Tested In: • Acinetobacter baylyi
Validation Method: transposon insertion and MIC testing

2

Evolution of Habitat-Dependent Antibiotic Resistance in Pseudomonas aeruginosa.

PMID 35766499 · 2022

The study identifies various genes and mutations associated with resistance to tobramycin, ceftazidime, and ceftazidime-avibactam in Pseudomonas aeruginosa, highlighting the impact of environmental conditions on the evolution of antibiotic resistance.

Gene Information

Gene Name: mpl
Allele: mpl
Encodes: protein involved in peptidoglycan muropeptide recycling
Source Database: Reslit
Mechanism: mutations in this gene contribute to ceftazidime resistance
Confers Resistance To: Ceftazidime
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Europe
Validation Method: genomic sequencing and susceptibility testing
Sequence Accession: NCBI BioProject PRJNA745005|PRJNA810193

3

Cefepime-taniborbactam activity against antimicrobial-resistant clinical isolates of Enterobacterales and Pseudomonas aeruginosa: GEARS global surveillance programme 2018-22.

PMID 39287999 · 2024

Cefepime-taniborbactam showed potent in vitro activity against Enterobacterales and P. aeruginosa, particularly effective against isolates with carbapenemase genes such as blaIMP, blaNDM, and blaVIM, as well as those with mutations in ftsI, ompK35, and ompK36.

Gene Information

Gene Name: mpl
Allele: mpl
Encodes: regulator of AmpC production
Source Database: Reslit
Confers Resistance To: Cefepime
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Asia/South Pacific|Europe|Latin America|Middle East/Africa|North America
Validation Method: molecular testing by WGS or PCR and Sanger sequencing
Sequence Accession: NCBI BioProject PRJNA1012345|NCBI BioProject PRJNA734525|NCBI BioProject PRJNA734526