mprf2

multiple peptide resistance factor

Validation StatusCandidate

Overview

Mechanism: inactivation of mprF2 abolishes the synthesis of three distinct amino-phosphatidylglycerols (PGs)
Validation Method: analysis of membrane lipid composition and MIC testing
Drug Classes: Colistin, Polymyxin b
Organisms: Enterococcus faecalis
Papers: 1
Databases: Reslit

Papers1

Role of mprF1 and mprF2 in the pathogenicity of Enterococcus faecalis.

PMID 22723861 · 2012

The study identifies mprF2 as the functional gene responsible for aminoacylation of phosphatidylglycerol in Enterococcus faecalis, contributing to resistance against cationic antimicrobial peptides such as colistin, polymyxin B, nisin, and HBD-3.

Gene Information

Gene Name: mprf2
Allele: mprF2
Encodes: multiple peptide resistance factor
Source Database: Reslit
Mechanism: inactivation of mprF2 abolishes the synthesis of three distinct amino-phosphatidylglycerols (PGs)
Confers Resistance To: ColistinPolymyxin b
Organisms Tested In: • Enterococcus faecalis
Validation Method: analysis of membrane lipid composition and MIC testing

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mprf2

Gene Information