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Explore antimicrobial resistance genes from the literature
multidrug resistance-associated protein 1
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| MRP1 | Reslit | 6 | - | human ovarian carcinoma cell line 2008wt +2 | Europe | 2012, 2014, 2015, 2016, 2017 | - | - |
| Mrp1 | Reslit | 1 | - |
| - |
| - |
| 2015 |
| - |
| - |
The G671V variant of MRP1/ABCC1 links doxorubicin-induced acute cardiac toxicity to disposition of the glutathione conjugate of 4-hydroxy-2-trans-nonenal.
The G671V variant of MRP1 is associated with increased doxorubicin-induced cardiac toxicity due to reduced efflux of GS-HNE, leading to increased intracellular accumulation of doxorubicin and oxidative stress.
Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1).
Folates increase MRP1-mediated efflux and drug resistance of substrates like daunorubicin, doxorubicin, and methotrexate.
Establishment and characterization of gemcitabine-resistant human cholangiocarcinoma cell lines with multidrug resistance and enhanced invasiveness
The study established gemcitabine-resistant human cholangiocarcinoma cell lines with multidrug resistance and enhanced invasiveness, highlighting the role of MRP1 in drug resistance.
RNAi validation of resistance genes and their interactions in the highly DDT-resistant 91-R strain of Drosophila melanogaster.
The study identifies and validates several genes involved in DDT resistance in the 91-R strain of Drosophila melanogaster, including cuticular proteins (Cyp4g1, Lcp1), cytochrome P450 monooxygenases (Cyp6g1, Cyp12d1), and ATP-binding cassette transporters (Mdr50, Mdr65, Mrp1).
Hypoxia can impair doxorubicin resistance of non-small cell lung cancer cells by inhibiting MRP1 and P-gp expression and boosting the chemosensitizing effects of MRP1 and P-gp blockers.
The study identifies MRP1 and P-gp as critical mediators of doxorubicin resistance in non-small cell lung cancer cells, demonstrating that their inhibition enhances the effectiveness of doxorubicin therapy.
Disruption of the association between drug transporter and actin cytoskeleton abolishes drug resistance in hypertrophic scar.
The study identifies P-glycoprotein and MRP1 as key contributors to drug resistance in hypertrophic scar fibroblasts through their enhanced expression and association with the actin cytoskeleton. Disrupting this association significantly reduces drug resistance.
Multidrug resistance transporter profile reveals MDR3 as a marker for stratification of blastemal Wilms tumour patients.
The study identifies MDR3 and MRP1 as multidrug resistance transporters that are upregulated in high-risk and blastemal Wilms tumour patients, correlating with poor prognosis and reduced disease-free survival.
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