mrp7

multidrug resistance protein 7

Validation StatusSupported

Overview

Mechanism: efflux pump
Validation Method: drug sensitivity assay and [3H]-paclitaxel accumulation and efflux studies
Papers: 5
Databases: Reslit

Papers5

Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance.

PMID 19720054 · 2010

Lapatinib and erlotinib reverse MRP7-mediated multidrug resistance by inhibiting the efflux function of MRP7, enhancing the intracellular accumulation of chemotherapeutic agents such as docetaxel, paclitaxel, vinblastine, and vinorelbine.

Gene Information

Gene Name: mrp7
Allele: MRP7
Encodes: multidrug resistance protein 7
Source Database: Reslit
Mechanism: efflux pump
Validation Method: drug sensitivity assay and [3H]-paclitaxel accumulation and efflux studies

Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10).

PMID 19841739 · 2009

Imatinib and nilotinib reverse MRP7-mediated multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 transporter.

Gene Information

Gene Name: mrp7
Allele: MRP7
Encodes: ATP-binding cassette sub-family C member 10
Source Database: Reslit
Validation Method: drug sensitivity assay, drug accumulation and efflux assay

PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter.

PMID 22578167 · 2012

Sildenafil and vardenafil reverse MRP7-mediated multidrug resistance by inhibiting the efflux function of MRP7, enhancing the sensitivity of MRP7-transfected cells to paclitaxel, docetaxel, and vinblastine.

Gene Information

Gene Name: mrp7
Allele: MRP7
Encodes: multidrug resistance protein 7
Source Database: Reslit
Mechanism: efflux transporter
Validation Method: cytotoxicity assay, [3H]-paclitaxel accumulation and efflux experiments

Reversal of MRP7 (ABCC10)-mediated multidrug resistance by tariquidar.

PMID 23393594 · 2013

Tariquidar reverses MRP7-mediated multidrug resistance by inhibiting MRP7 protein expression and function, increasing the sensitivity of MRP7-expressing cells to anticancer drugs such as paclitaxel, docetaxel, vincristine, vinblastine, and vinorelbine.

Gene Information

Gene Name: mrp7
Allele: MRP7
Encodes: ATP-binding cassette (ABC) transporter
Source Database: Reslit
Validation Method: expression in HEK293 cells, resistance to MRP7 substrates

bba, a synthetic derivative of 23-hydroxybutulinic acid, reverses multidrug resistance by inhibiting the efflux activity of MRP7 (ABCC10).

PMID 24069321 · 2013

BBA reverses MRP7-mediated multidrug resistance by inhibiting the efflux function of MRP7 without affecting the intracellular ATP levels.

Gene Information

Gene Name: mrp7
Allele: MRP7
Encodes: ATP-binding cassette sub-family C member 10
Source Database: Reslit
Validation Method: cytotoxicity assay, [3H]-paclitaxel accumulation and efflux assay, immunoblotting, immunofluorescence

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mrp7

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