Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ABC transporter
Overview
| Candidate |
| A84V | - | Acinetobacter baumannii | Tigecycline | Reslit | Candidate |
Synergistic effect of imp/ostA and msbA in hydrophobic drug resistance of Helicobacter pylori.
The study identifies imp/ostA and msbA as critical genes involved in hydrophobic drug resistance in Helicobacter pylori, demonstrating their roles in glutaraldehyde, erythromycin, novobiocin, rifampicin, and ethidium bromide resistance through gene deletion and complementation experiments.
Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis.
The study identifies several β-lactam resistance genes, including ampC, lacA, pbp2, pbp3, pbp4a, pbp6a, and pbp7, as well as multidrug efflux pumps such as acrAB-tolC, acrAD-tolC, mdtABC-tolC, emrAB-tolC, mexAB-oprM, and others. Additionally, genes like bacA, ksgA, crcB, and rarD are implicated in resistance to bacitracin, kasugamycin, streptomycin, camphor, and chloramphenicol, respectively.
Acinetobacter baumannii Repeatedly Evolves a Hypermutator Phenotype in Response to Tigecycline That Effectively Surveys Evolutionary Trajectories to Resistance.
The study identifies multiple genes, including adeS, msbA, rrf, gna, and rpsJ, that are associated with tigecycline resistance in Acinetobacter baumannii. Mutations in these genes contribute to the development of high-level tigecycline resistance through various mechanisms such as efflux pump overexpression, altered ribosome function, and cell wall synthesis disruption.
Metagenomic read cloud sequencing reveals antibiotic resistance gene dynamics in the gut microbiome of a hematopoietic cell transplant patient
The study identified 46 antibiotic resistance genes in the pre-transplant E. coli strain, including genes conferring resistance to beta-lactams, aminoglycosides, polymyxins, bacitracin, and multiple drugs through efflux pumps.
Functional metagenomics reveals antibiotic resistance determinants in dairy-associated microbial communities
The study identified several antibiotic resistance (AR) determinants in dairy products and processing environments, including genes conferring resistance to beta-lactams, tetracyclines, glycopeptides, macrolides, and streptogramins. Notably, Lactococcus lactis was found to be a significant reservoir of multidrug-resistant genes.
Preterm infants harbour diverse Klebsiella populations, including atypical species that encode and produce an array of antimicrobial resistance- and virulence-associated factors.
The study identified various antimicrobial resistance genes in Klebsiella isolates from preterm infants, highlighting the presence of multidrug resistance mechanisms.
Characterization of methicillin-resistant Staphylococcus aureus through genomics approach.
The study characterized methicillin-resistant Staphylococcus aureus (MRSA) isolates, identifying genes such as mecA, blaZ, norA, gyrA, gyrB, tet-38, mepA, mepR, arlS, arlR, mgrA, clsA, dfrC, msbA, rpoB32, mprF, and mrpA, which confer resistance to various antibiotics.
Complete Genomic Analysis of VRE From a Cattle Feedlot: Focus on 2 Antibiotic Resistance.
The study identified multiple antibiotic resistance genes in vancomycin-resistant enterococci (VRE) isolates from a cattle feedlot, including vanC1, vanC2/C3, vanXY-C, VanR, macA, macB, rlmA (II), erm(A), aac(6')-la, blaEC, tet(A), tet(L), S10p, gyrA, gyrB, msbA, S12p, rpoB, mdfA/cmr, liaF, liaR, liaS, bcrC, mprF, pgsA, ef-G, ef-TU, ddl, alr, kasA, isotRNA, inhA, fabl, murA, folA, and Dfr, which confer resistance to various antibiotics such as vancomycin, macrolides, aminoglycosides, β-lactams, tetracyclines, quinolones, and others.
Active antibiotic resistome in soils unraveled by single-cell isotope probing and targeted metagenomics.
The study identifies various AMR genes and mutations in soil samples, highlighting the active resistome in agricultural and natural soils. Key findings include the detection of genes like gyrA, bcrA, and macB, which confer resistance to antibiotics such as ciprofloxacin and meropenem. The research emphasizes the importance of phenotypic resistance assessment in environmental AMR monitoring.
Phenotypic and genotypic characterization of antimicrobial resistance profiles in Salmonella isolated from waterfowl in 2002-2005 and 2018-2020 in Sichuan, China.
The study identified multiple AMR genes and mutations in Salmonella isolates from waterfowl in Sichuan, China, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline efflux pumps, and quinolone resistance genes. Mutations in gyrA and gyrB were associated with nalidixic acid resistance.
Hybrid Genomic Analysis of Salmonella enterica Serovar Enteritidis SE3 Isolated from Polluted Soil in Brazil.
The study identified several antimicrobial resistance genes in Salmonella enterica serovar Enteritidis SE3, including aac(6')-Iaa, mdfA, golS, and msbA, which confer resistance to aminoglycosides, tetracycline, monobactam, and nitroimidazole, respectively.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Lipopolysaccharide integrity primes bacterial sensitivity to a cell wall-degrading intermicrobial toxin.
The study identifies msbA and lpxK as genes involved in lipopolysaccharide (LPS) biosynthesis that confer resistance to the Tae1 toxin in Escherichia coli. Disruption of these genes leads to resistance against Tae1-mediated lysis, highlighting the role of LPS integrity in modulating susceptibility to cell wall-degrading toxins.
Resistance mechanisms of tigecycline in Acinetobacter baumannii.
The study identifies several efflux pumps, outer membrane permeability alterations, and antibiotic target modifications as key mechanisms of tigecycline resistance in Acinetobacter baumannii.
Global Antimicrobial Resistance Gene Study of Helicobacter pylori: Comparison of Detection Tools, ARG and Efflux Pump Gene Analysis, Worldwide Epidemiological Distribution, and Information Related to the Antimicrobial-Resistant Phenotype.
The study identified 42 antimicrobial resistance genes (ARG) in Helicobacter pylori, including 16 related to single antibiotic class resistance and 26 related to multidrug resistance. Key genes include hp1181, copA, msbA, vanT, vanTr, mepA, and several RND efflux pumps. These genes were validated through multiple detection tools and curation processes.
Bacterial diversity and resistome analysis of drinking water stored in cisterns from two First Nations communities in Manitoba, Canada.
The study identified a diverse array of antimicrobial resistance genes in drinking water stored in cisterns from two First Nations communities in Manitoba, Canada. Key findings include the presence of genes such as aac(3')-Ia, aac(6')-Iia, aac(6')-Iic, aph(3')-Ia, acrD, smeB, smeR, FEZ-1, rm3, SPG-1, OXA-21, OXA-119, OXA-205, dfrA14, dfrB6, acrB, acrF, adeF, ceoB, emrA, mexE, mexF, mexI, oprN, oqxB, BRP(MBL), vanSO, axyY, CRP, efrB, macB, mexB, mexC, mexD, mexK, mexQ, mexW, mexY, mtrA, muxB, muxC, oleB, oleC, ompB, oprM, smeD, smeE, golS, mdsB, PER-2, TEM-126, msbA, arnA, bacA, bcrA, MCR-5, rosA, rosB, rpoB2, ugd, mexN, taeA, efpA, rphA, rphB, otr(A), otrC, tetA(48 ), ompH, and triC, which confer resistance to various antibiotics including aminoglycosides, beta-lactams, cephalosporins, carbapenems, fluoroquinolones, macrolides, monobactams, nitroimidazoles, peptides, phenicols, pleuromutilins, rifamycins, tetracyclines, and triclosan.
Genome mining of Escherichia coli WG5D from drinking water source: unraveling antibiotic resistance genes, virulence factors, and pathogenicity.
The study identifies multiple antibiotic resistance genes in E. coli WG5D, including multidrug efflux pumps and genes conferring resistance to various antibiotics such as fluoroquinolones, cephalosporins, and glycopeptides.
Molecular mechanisms of tigecycline-resistance among Enterobacterales.
The paper reviews the molecular mechanisms of tigecycline resistance in Enterobacterales, highlighting the roles of efflux pumps, tet genes, and other resistance mechanisms. It identifies several tigecycline resistance genes, including tet(X), tet(X1), tet(X2), tet(X3), tet(X4), tet(M), tet(A), tet(B), tet(Y), and others, along with their associated resistance profiles.
Genomic analysis of Enterobacter cloacae complex from Southern Thailand reveals insights into multidrug resistance genotypes and genetic diversity.
The study identified multiple antimicrobial resistance genes in Enterobacter cloacae complex isolates from Southern Thailand, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and efflux pumps. Notably, the mcr-9 gene was found to confer colistin resistance.
Genomic Characterization of Pan-Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh.
The study identifies 42 antimicrobial resistance (AMR) genes in the pan-drug resistant Klebsiella pneumoniae isolate KPNW, including beta-lactamases (bla CTX-M-15, bla NDM-1, bla OXA-1, bla TEM-63, bla TEM-104, bla SHV-28), tetracycline resistance genes (tet(A)), and efflux pump genes (oqxA, oqxB, marA, marR, ompK37, pbp3, crp, h-ns, kpnG, kpnH, parC, rsmA). Additionally, the isolate shows resistance to polymyxin B and colistin through modifications in lipid A (eptB, arnT, lptD, msbA, vanG) and other mechanisms.
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