msr(A)
macrolide and streptogramin B efflux pump
Overview
- Drug Classes
- macrolides, streptogramin b, type b streptogramins, erythromycin, clindamycin
- Organisms
- Staphylococcus aureus, coagulase-negative staphylococci
- Papers
- 3
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
PMID 11585788 · 2023The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Gene Information
- Gene Name
- msr(A)
- Allele
- msrA
- Encodes
- macrolide and streptogramin B efflux pump
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
Isolation Details
Practical disk diffusion method for detection of inducible clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci.
PMID 14532213 · 2003The study identifies and characterizes the genes ermA, ermC, and msrA responsible for inducible and constitutive clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci using PCR and disk diffusion testing.
Gene Information
- Gene Name
- msr(A)
- Allele
- msrA
- Encodes
- efflux pump
- Validation Method
- PCR and disk diffusion testing
Mechanism
active efflux of macrolides and type B streptogramins
Confers Resistance To
Organisms Tested In
Testing for induction of clindamycin resistance in erythromycin-resistant isolates of Staphylococcus aureus.
PMID 15814990 · 2005The study identifies ermA, ermC, and msrA as genes responsible for clindamycin resistance in erythromycin-resistant Staphylococcus aureus isolates, with distinct phenotypes observed in disk diffusion testing.
Gene Information
- Gene Name
- msr(A)
- Allele
- msrA
- Encodes
- efflux pump
- Validation Method
- PCR and disk diffusion testing
Confers Resistance To
Organisms Tested In
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