Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
putative ABC transporter
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| msrC | Reslit | 20 | Erythromycin, Azithromycin +9 | Enterococcus faecium +13 | Spain, Canada, China, South Brazil, Europe|Southern and Western Ireland, Australia, South Korea|Australia|America|The Netherlands|China, Estonia|swine, Slovakia|Hungary, Alberta|Canada|Alberta, Canada, United States, India, Argentina|Australia|Brazil|China|India|United States, Guangzhou, China, Swiss Canton Tessin|various herds|Switzerland, Chettia Chlef Hospital, South Africa |
| 2000, 2001, 2015, 2016, 2017, 2018, 2019, 2021, 2022, 2023, 2024 |
| AJ243209 |
| - |
| msr(C) | Card DatabaseResFinder Database | 2 | QUINUPRISTIN, PRISTINAMYCIN IA +3 | Enterococcus faecium | - | 2001 | AY004350, AF313494 | AAK01167.1 |
| Msr(C) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 20 | TYLOSIN, STREPTOGRAMIN B +23 | Enterococcus faecium +10 | Pakistan|United States|USA, China, Brazil, South Africa, Ghana, Slovak Republic, Europe, Bangladesh, Switzerland | 2001, 2018, 2019, 2020, 2022, 2023, 2024, 2025, 2026 | AF313494.1 | AAK01167.1 |
| MsrC | Reslit | 1 | Erythromycin, Telithromycin +1 | Staphylococcus aureus | - | 2021 | - | - |
Macrolide Resistance Genes in Enterococcus spp.
The study identified the presence of ermB and ermA genes in various Enterococcus species, which confer resistance to macrolides, lincosamides, and streptogramins. Additionally, a novel gene, msrC, was discovered in Enterococcus faecium, which is proposed to encode a putative ABC transporter involved in macrolide resistance.
Disruption of an Enterococcus faecium species-specific gene, a homologue of acquired macrolide resistance genes of staphylococci, is associated with an increase in macrolide susceptibility.
The study identified msrC, a species-specific gene in Enterococcus faecium, which contributes to macrolide resistance. Disruption of msrC led to increased susceptibility to erythromycin, azithromycin, tylosin, and quinupristin.
Disruption of an Enterococcus faecium species-specific gene, a homologue of acquired macrolide resistance genes of staphylococci, is associated with an increase in macrolide susceptibility.
Disruption of an Enterococcus faecium species-specific gene, a homologue of acquired macrolide resistance genes of staphylococci, is associated with an increase in macrolide susceptibility.
Disruption of an Enterococcus faecium species-specific gene, a homologue of acquired macrolide resistance genes of staphylococci, is associated with an increase in macrolide susceptibility.
Disruption of an Enterococcus faecium species-specific gene, a homologue of acquired macrolide resistance genes of staphylococci, is associated with an increase in macrolide susceptibility.
Disruption of an Enterococcus faecium species-specific gene, a homologue of acquired macrolide resistance genes of staphylococci, is associated with an increase in macrolide susceptibility.
Disruption of an Enterococcus faecium species-specific gene, a homologue of acquired macrolide resistance genes of staphylococci, is associated with an increase in macrolide susceptibility.
Effect of in-feed administration and withdrawal of tylosin phosphate on antibiotic resistance in enterococci isolated from feedlot steers.
The study found that tylosin phosphate administration increased the proportion of erythromycin and tylosin resistant enterococci, but withdrawal reduced their prevalence. The resistance was primarily mediated by the erm(B) gene and msrC gene.
Characteristic of Enterococcus faecium clinical isolates with quinupristin/dalfopristin resistance in China.
The study reports the first case of quinupristin/dalfopristin (Q/D)-resistant Enterococcus faecium clinical isolates in China, identifying the genes ermB, msrC, and vatE as responsible for Q/D resistance.
RNA-seq and Tn-seq reveal fitness determinants of vancomycin-resistant Enterococcus faecium during growth in human serum.
The study identifies genes involved in nucleotide biosynthesis and carbohydrate metabolism that are essential for the growth of vancomycin-resistant Enterococcus faecium in human serum, highlighting potential targets for novel antimicrobials.
Critical steps in clinical shotgun metagenomics for the concomitant detection and typing of microbial pathogens.
The study characterizes various AMR genes involved in resistance to multiple antibiotics, including beta-lactams, aminoglycosides, macrolides, tetracyclines, and others, in different bacterial species such as Staphylococcus aureus, Enterococcus faecium, and Serratia marcescens.
Antimicrobial Resistance Profiles in Enterococcus spp. Isolates From Fecal Samples of Wild and Captive Black Capuchin Monkeys (Sapajus nigritus) in South Brazil.
The study identified the presence of antimicrobial resistance genes msrC, tet(M), and tet(L) in Enterococcus spp. isolates from wild and captive black capuchin monkeys in South Brazil, indicating the spread of resistance mechanisms in these bacterial populations.
Heterogeneity of macrolide-lincosamide-streptogramin phenotype & conjugal transfer of erm(B) in Pediococcus pentosaceus.
The study identified the erm(B) and msr(C) genes in Pediococcus pentosaceus isolates, which confer resistance to macrolide-lincosamide-streptogramin B antibiotics. The erm(B) gene was successfully transferred to Enterococcus faecalis via conjugation.
Spatiotemporal dynamics of multidrug resistant bacteria on intensive care unit surfaces.
The study identified various AMR genes, including bla OXA-23, bla OXA-66, bla NDM-1, bla NDM-5, bla NDM-7, bla OXA-181, bla OXA-232, erm(B), vanA, msr(C), fosA, oqxA, aph(3')-lb, bla PAO, bla OXA-50, catB7, and bla GES-5, in multidrug-resistant bacteria isolated from ICU surfaces in Pakistan and the USA.
In Vitro Pharmacodynamic Analyses Help Guide the Treatment of Multidrug-Resistant Enterococcus faecium and Carbapenem-Resistant Enterobacter cloacae Bacteremia in a Liver Transplant Patient.
The study identifies various AMR genes and mutations in Enterococcus faecium and Enterobacter hormaechei isolates from a liver transplant patient, highlighting their roles in resistance to multiple antibiotics.
Functional metagenomics reveals antibiotic resistance determinants in dairy-associated microbial communities
The study identified several antibiotic resistance (AR) determinants in dairy products and processing environments, including genes conferring resistance to beta-lactams, tetracyclines, glycopeptides, macrolides, and streptogramins. Notably, Lactococcus lactis was found to be a significant reservoir of multidrug-resistant genes.
Emergence of vanA-Type Vancomycin-Resistant Enterococcus faecium ST 78 Strain with a rep2-Type Plasmid Carrying a Tn1546-Like Element Isolated from a Urinary Tract Infection in China.
The study identifies a vanA-type vancomycin-resistant Enterococcus faecium ST78 strain carrying a rep2-type plasmid with a Tn1546-like element. The strain exhibits resistance to multiple antibiotics, including vancomycin, teicoplanin, and aminoglycosides, due to the presence of the vanA, ant(6)-Ia, aph(3')-III, aac(6')-Ii, and msr(C) genes.
Antimicrobial Resistance in Porcine Enterococci in Australia and the Ramifications for Human Health.
The study identified antimicrobial resistance genes such as aac(6')-li, ermB, msrC, and vanC in porcine Enterococcus faecium isolates, highlighting the presence of resistance to aminoglycosides, macrolides, streptogramins, and glycopeptides.
Full pathogen characterisation: species identification including the detection of virulence factors and antibiotic resistance genes via multiplex DNA-assays.
The study presents a DNA microarray-based assay for the simultaneous detection of 44 sepsis-relevant bacterial pathogens, 360 virulence factors, and 409 antibiotic resistance genes. The assay was evaluated with 14 multidrug-resistant strains, including all ESKAPE pathogens.
New Insights into the Virulence Traits and Antibiotic Resistance of Enterococci Isolated from Diverse Probiotic Products.
The study identifies multiple antibiotic resistance genes, including msrC, lsaA, aac(6')-Ii, vanC, and tetM, in enterococci isolated from probiotic products, highlighting the potential risk of antimicrobial resistance and virulence factors in these isolates.
Molecular Characterization of Enterococcus Isolates From Different Sources in Estonia Reveals Potential Transmission of Resistance Genes Among Different Reservoirs.
The study identified vanB genes in two vancomycin-resistant E. faecalis isolates and characterized various tetracycline, macrolide, lincosamide, and aminoglycoside resistance genes in E. faecalis and E. faecium isolates from different sources in Estonia.
Ribosome Protection Proteins-'New' Players in the Global Arms Race with Antibiotic-Resistant Pathogens.
The paper discusses ribosome protection proteins (RPPs) as significant contributors to antibiotic resistance, particularly against tetracyclines, fusidic acid, and various other antibiotics targeting the ribosome. Key RPPs include TetM, TetO, FusB, VgaA, LsaA, MsrE, MsrA, optrA, and poxtA, which confer resistance through mechanisms involving direct interaction with the ribosome and displacement of antibiotics.
Antimicrobial Resistance of Enterococcus sp. Isolated from Sheep and Goat Cheeses.
The study identified the presence of vanA, ermB, ermA, ermC, and msrC genes in Enterococcus isolates from sheep and goat cheeses, contributing to resistance against vancomycin and erythromycin.
Genetic description of VanD phenotype vanA genotype in vancomycin-resistant Enterococcus faecium isolates from a Bone Marrow Transplantation Unit.
The study characterizes the genetic structure of vancomycin-resistant Enterococcus faecium isolates displaying a VanD phenotype with a vanA genotype, highlighting the presence of various resistance genes and genetic variations within the van transposon.
Antimicrobial Resistance in Enterococcus Spp. Isolated from a Beef Processing Plant and Retail Ground Beef.
The study identified several AMR genes, including tet(M), erm(B), msrC, aac(6')-Ii, and optrA, in Enterococcus faecalis and Enterococcus faecium isolates from a beef processing plant and retail ground beef.
Whole genome sequence analyses-based assessment of virulence potential and antimicrobial susceptibilities and resistance of Enterococcus faecium strains isolated from commercial swine and cattle probiotic products.
The study identified several antimicrobial resistance (AMR) genes in Enterococcus faecium strains isolated from commercial swine and cattle probiotics, including aac(6')-Ii, aph(3')-III, ant(6)-Ia, tet(L), tet(M), msrC, and cat-(pc194). These genes confer resistance to aminoglycosides, tetracyclines, macrolides, lincosamides, streptogramin B, and phenicols.
Longitudinal Analysis of Antimicrobial Resistance among Enterococcus Species Isolated from Australian Beef Cattle Faeces at Feedlot Entry and Exit.
Prevalence of macrolide-lincosamide-streptogramin resistant lactic acid bacteria isolated from food samples.
The study identifies the presence of MLS resistance genes ermB, mefA/E, msrA/B, and msrC in lactic acid bacteria isolated from food samples, highlighting the prevalence of macrolide-lincosamide-streptogramin resistance in LAB.
A survey on antimicrobial resistance genes of frequently used probiotic bacteria, 1901 to 2022.
The study identified various antimicrobial resistance genes in probiotic bacteria, highlighting the presence of mobile genetic elements and the potential for horizontal gene transfer.
Identification and Characterization of a Vancomycin Intermediate-Resistant Staphylococcus haemolyticus Isolated from Guangzhou, China.
The study identifies vancomycin intermediate-resistant Staphylococcus haemolyticus SH-1 carrying multiple drug resistance genes and novel mutations in WalK gene associated with vancomycin resistance.
Elucidation of the Bovine Intramammary Bacteriome and Resistome from healthy cows of Swiss dairy farms in the Canton Tessin.
The study identified the presence of the tetracycline resistance gene tetK in Mammaliicoccus sciuri isolates, which was associated with tetracycline resistance. The gene was found on small plasmids, suggesting a potential mechanism for horizontal gene transfer.
Antimicrobial resistance and whole genome sequencing of novel sequence types of Enterococcus faecalis, Enterococcus faecium, and Enterococcus durans isolated from livestock.
The study identifies several antimicrobial resistance genes in Enterococcus species isolated from livestock in South Africa, highlighting the presence of multidrug-resistant strains and emphasizing the need for genomic surveillance to monitor the spread of antimicrobial resistance in food chain animals.
Draft genome sequencing data of Enterococcus faecium BT22, a vancomycin-resistant opportunistic pathogen isolated from hospital effluents.
The study identified 12 antibiotic resistance genes and one virulence gene in strain BT22, including genes conferring resistance to aminoglycosides, macrolides, tetracyclines, and vancomycin.
High Diversity but Monodominance of Multidrug-Resistant Bacteria in Immunocompromised Pediatric Patients with Acute Lymphoblastic Leukemia Developing GVHD Are Not Associated with Changes in Gut Mycobiome.
The study identifies multiple multidrug-resistant bacteria, including Enterococcus faecium and Klebsiella pneumoniae, carrying various resistance genes such as msr(C), erm(T), aac(6')-li, dfrG, ant(6)-la, aph(3")-Ib, sul2, and aph(6)-ld, which confer resistance to multiple antibiotics.
Enterococcus species: insights into antimicrobial resistance and whole-genome features of isolates recovered from livestock and raw meat in Ghana.
The study identified various antimicrobial resistance genes in Enterococcus spp. isolated from livestock and raw meat in Ghana, including genes conferring resistance to erythromycin, tetracycline, chloramphenicol, and other antibiotics. Notable genes include aac(6')-Ii, aph(3')-III, ant(6)-Ia, erm(B), erm(T), msr(C), lsa(A), lsa(E), lnu(B), tet(L), tet(M), tet(S), dfrG, cat, pbp5, and ClpL.
Gut diversity and the resistome as biomarkers of febrile neutropenia outcome in paediatric oncology patients undergoing hematopoietic stem cell transplantation.
The study identifies several antibiotic-resistance genes associated with febrile neutropenia in pediatric oncology patients undergoing hematopoietic stem cell transplantation, including msr(C), dfrG, erm(T), VanHAX, aac(6')-Ib, aph(3')-III, ant(6)-Ia, and aac(6')-Ii.
Genomic diversity, antibiotic resistance, and virulence in South African Enterococcus faecalis and Enterococcus lactis isolates.
The study identifies several antibiotic resistance genes in South African Enterococcus faecalis and Enterococcus lactis isolates, including dfrE, vanW, vanT, efrA, tet(M), AAC(6')-Ii, msrC, and vanY, which confer resistance to trimethoprim, glycopeptides, tetracycline, macrolides, and aminoglycosides.
Screening and Genomic Profiling of Antimicrobial Bacteria Sourced from Poultry Slaughterhouse Effluents: Bacteriocin Production and Safety Evaluation.
The study identified several bacteriocin gene clusters, including a novel class IId bacteriocin, lactococcin P1A (LcnP1A), in L. lactis SWD9. Additionally, various bacteriocins such as enterocin A, enterocin B, and garvieacin Q were characterized in different bacterial isolates.
Probiotic potential and antimicrobial efficacy of a dairy isolate, Enterococcus faecium MBBL3.
E. faecium MBBL3 exhibits antimicrobial activity against bovine mastitis pathogens, with Enterolysin_A showing strong molecular interactions with virulence-associated proteins.
Emergence of vancomycin-resistant Enterococcus faecium vanA ST612 with reduced daptomycin susceptibility, Switzerland, 2018 to 2024.
The study identifies mutations in liaR (W73C) and liaS (T120A) associated with reduced daptomycin susceptibility in vancomycin-resistant Enterococcus faecium vanA ST612. It also characterizes resistance genes including vanA, aac(6')-I, msr(C), and ant(6)-Ia.
Elucidation of population-based bacterial adaptation to antimicrobial treatment by single-cell sequencing analysis of the gut microbiome of a hospital patient.
The study identified 29 ARG subtypes across eight types in 13 known, five unknown, and 18 unclassified species, highlighting the complex and dynamic nature of antimicrobial resistance in the gut microbiome. Notably, the cfr(C) gene was detected in 11 bacterial species following antimicrobial treatment, with mutation patterns characterized in several species.
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