Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
macrolide efflux pump
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| msr(E) | Card DatabaseResFinder Database | 2 | QUINUPRISTIN, PRISTINAMYCIN IA +3 | Pasteurella multocida +1 | - | 2011 | FR751518 | ACB05808.1 |
| Msr(E) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 44 | Macrolide, STREPTOGRAMIN +15 | Pasteurella multocida +21 | United States|France, Vietnam, Croatia|India, Singapore, China, Pakistan, Alberta|North America, Argentina, Thailand|Nepal, Brazil, northwest China, Bangladesh, Alexandria, Egypt, Egypt, Southeastern U.S., Bulgaria, India, Europe, Europe|Italy, Paraguay|Northern Spain, Spain, Egypt|Tunisia|Middle East|North Africa, Asia|China | 2011, 2013, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | JF769133 | AAN87714.1 |
| msrE | Reslit | 45 | Macrolide, Erythromycin +13 | Acinetobacter baumannii +28 | China|Beijing, China, Texas|Nebraska|Alberta|France|Alberta, Canada|Nebraska, Texas, USA|Nantes, France, North America, Singapore, China, Italy, Amazon River|Kalamas River|Cam River|Cambridge|Amazon River Plume, Malaysia, North America|Asia|Europe|Australia|South America, Europe|United States, Africa|Asia|Europe|North America|South America|global, Egypt, India, Kenya, Switzerland, Italy|Taiwan|Spain|China|Australia|United States|Egypt|Bolivia, Pakistan|Karachi, Pakistan, Moscow, Russia, Greece, Central Greece, Virginia|Illinois, Cambodia, Japan, Bangladesh, Armenia, Terengganu, Malaysia|Malaysia, Calabria|Italy, Spain, Iran | 2013, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | CP003846|CP003887|CP003849|CP003850|CP003888|CP003847|CP003848|CP003907|CP003908 | - |
| msr E | Reslit | 3 | Macrolide, Lincosamide +1 | Enterobacteriaceae +7 | United States|Virginia, South Africa, Shandong, China | 2021, 2022, 2025 | PRJNA765178 | - |
| MsrE | Reslit | 1 | Macrolide | Pseudomonas aeruginosa | - | 2021 | - | - |
| msr ( E ) | Reslit | 1 | Macrolide | Pseudomonas aeruginosa | Singapore | 2023 | PRJNA811722|PRJNA507901|PRJNA656645 | - |
| msr (E) | Reslit | 2 | Erythromycin, Clarithromycin +1 | Citrobacter freundii +1 | Finland, Hebei, China|Hebei province, China | 2023, 2025 | GCA_012371325.1|NZ_JAAZQX010000010.1 | - |
Molecular basis of macrolide, triamilide, and lincosamide resistance in Pasteurella multocida from bovine respiratory disease.
Combinations of macrolide resistance determinants in field isolates of Mannheimia haemolytica and Pasteurella multocida.
The study identifies three macrolide resistance determinants, erm(42), msr(E), and mph(E), in field isolates of Mannheimia haemolytica and Pasteurella multocida. These genes confer resistance to macrolides, lincosamides, and streptogramin B, with erm(42) mediating resistance through 23S rRNA methylation, msr(E) through efflux, and mph(E) through phosphorylation.
Comparative genomics of IncL/M-type plasmids: evolution by acquisition of resistance genes and insertion sequences.
Comparative genomics of IncL/M-type plasmids: evolution by acquisition of resistance genes and insertion sequences.
Comparative genomics of IncL/M-type plasmids: evolution by acquisition of resistance genes and insertion sequences.
Complete genome analysis of three Acinetobacter baumannii clinical isolates in China for insight into the diversification of drug resistance elements.
The study identifies multiple AMR genes and resistance islands in three multidrug-resistant Acinetobacter baumannii isolates, highlighting the role of genomic plasticity in the dissemination of resistance mechanisms.
Comparative Genomic Analysis of Mannheimia haemolytica from Bovine Sources.
The study identified a bla ROB-1 gene in an integrative conjugative element (ICE) of M. haemolytica, which had a single nucleotide substitution leading to a non-functional gene and sensitivity to ampicillin.
Genomic signatures of Mannheimia haemolytica that associate with the lungs of cattle with respiratory disease, an integrative conjugative element, and antibiotic resistance genes.
The study identifies multiple antibiotic resistance genes in Mannheimia haemolytica, particularly in genotype 2, subtype 2b isolates, which are associated with the lungs of cattle with respiratory disease and contain various combinations of resistance genes.
The tet39 Determinant and the msrE-mphE Genes in Acinetobacter Plasmids Are Each Part of Discrete Modules Flanked by Inversely Oriented pdif (XerC-XerD) Sites.
The study identifies the tet39 tetracycline resistance determinant and the msrE-mphE macrolide resistance genes in an Acinetobacter plasmid, pS30-1, which confers resistance to tetracycline and erythromycin.
New eight genes identified at the clinical multidrug-resistant Acinetobacter baumannii DMS06669 strain in a Vietnam hospital.
The study identified 18 antibiotic resistance genes in the multidrug-resistant Acinetobacter baumannii DMS06669 strain, including eight novel genes not previously reported in A. baumannii. These genes conferred resistance to various antibiotic classes, including aminoglycosides, beta-lactams, phenicols, sulfonamides, tetracyclines, macrolides, lincosamides, streptogramin B, and rifampicins.
Functional Repertoire of Antibiotic Resistance Genes in Antibiotic Manufacturing Effluents and Receiving Freshwater Sediments.
The study identified numerous antibiotic resistance genes (ARGs) in antibiotic manufacturing effluents and receiving sediments, highlighting the presence of both known and potentially novel resistance mechanisms. Key findings include the discovery of macrolide resistance genes such as hflx, msr(e), mph(e), mph(g), and mef(c), as well as sulfonamide resistance genes sul1 and sul2, and beta-lactamase genes like bla ges-1, bla veb-9, and bla cm y-10. Additionally, trimethoprim resistance genes dfr14, dfra1, and dfr17 were identified.
Acquisition of resistance to carbapenem and macrolide-mediated quorum sensing inhibition by Pseudomonas aeruginosa via ICE(Tn4371) 6385.
The study identifies a novel integrative and conjugative element (ICE) carrying blaNDM-1, msr(E), and floR, which confers resistance to carbapenems, macrolides, and florfenicol in Pseudomonas aeruginosa.
Draft genome sequence data of a tigecycline-resistant Enterobacter cloacae ST93 clinical strain isolated from bloodstream infection.
The study reports the draft genome sequence of a tigecycline-resistant Enterobacter cloacae ST93 clinical isolate, TREC1, which harbors multiple antimicrobial resistance genes, including those encoding resistance to beta-lactams, aminoglycosides, fluoroquinolones, fosfomycin, macrolides, lincosamides, streptogramin B, phenicols, sulfonamides, trimethoprim, and tetracyclines. The isolate is resistant to all antibiotics tested except colistin.
Pilot Safety Evaluation of a Novel Strain of Bacteroides ovatus.
The study identified several antibiotic resistance genes in Bacteroides ovatus ELH-B2, including those conferring resistance to tetracycline, erythromycin, aminoglycosides, macrolides, and other antibiotics. These genes were validated through minimum inhibitory concentration (MIC) tests.
Characterization of the emerging multidrug-resistant Salmonella enterica serovar Indiana strains in China.
The study identifies multiple AMR genes, including aac(6')-Ib, blaOXA-30, catB3, arr-3, qacE, sul1, intI1, armA, msrE, mphE, and blaCTX-M-3, in multidrug-resistant Salmonella enterica serovar Indiana strains in China, highlighting the role of class I integrons in the dissemination of resistance.
Diversity, Virulence, and Antimicrobial Resistance in Isolates From the Newly Emerging Klebsiella pneumoniae ST101 Lineage.
The study characterizes the antimicrobial resistance genes and mutations in the emerging Klebsiella pneumoniae ST101 lineage, highlighting the presence of multiple resistance mechanisms including carbapenemases, extended-spectrum beta-lactamases, and various other resistance genes.
Tracking Carbapenem-Producing Klebsiella pneumoniae Outbreak in an Intensive Care Unit by Whole Genome Sequencing.
The study identified multiple carbapenem-resistant Klebsiella pneumoniae (CP-Kp) strains carrying various resistance genes, including blaKPC-2, blaNDM-1, and others, contributing to multidrug resistance. Plasmid analysis revealed the presence of resistance genes on different plasmids, highlighting the complexity of resistance mechanisms.
Characterization of Discriminatory Antimicrobial Resistance Genes in Aquatic Environments Using Machine Learning
The study identifies discriminatory antibiotic resistance genes (ARGs) using an extremely randomized tree (ERT) algorithm, highlighting genes like sul1, tet(W), and ermB as significant markers for differentiating resistomes across various aquatic environments.
Molecular epidemiology and antimicrobial resistance features of Acinetobacter baumannii clinical isolates from Pakistan.
The study identified multiple antimicrobial resistance genes in Acinetobacter baumannii isolates from Pakistan, including bla OXA-23, bla GES-11, aphA6a, aacA4, sul1, drfA7, msr(E), and mph(E). These genes contribute to resistance against various antibiotics such as carbapenems, cephalosporins, aminoglycosides, sulfonamides, and macrolides.
Antimicrobial Resistance in Members of the Bacterial Bovine Respiratory Disease Complex Isolated from Lung Tissue of Cattle Mortalities Managed with or without the Use of Antimicrobials.
The study identified several AMR genes, including aadA31, bla ROB-1, floR, mph(E), msr(E), and tet(H), in bovine respiratory disease organisms, highlighting the impact of antimicrobial use on AMR development.
An NDM-1-Producing Acinetobacter towneri Isolate from Hospital Sewage in China.
What do we know about plasmids carried by members of the Acinetobacter genus?
The paper reviews the diversity and characteristics of plasmids in Acinetobacter species, particularly highlighting the presence of various beta-lactamase genes (blaOXA-23, blaOXA-58, blaOXA-24, blaPER-1, blaADC-25), aminoglycoside resistance genes (aadB, aphA6), tetracycline resistance gene (tet(39)), macrolide resistance genes (mph(E), msr(E)), sulfonamide resistance gene (sul2), and other resistance genes (bcr). These genes are primarily found on plasmids and contribute to multidrug resistance in clinical isolates.
Concordance of disk diffusion, broth microdilution, and whole-genome sequencing for determination of in vitro antimicrobial susceptibility of Mannheimia haemolytica.
The study identified several AMR genes and mutations in Mannheimia haemolytica isolates, including floR, bla-OXA2, bla-ROB1, tetH/R, erm42, msrE, mphE, and fluoroquinolone resistance mutations in gyrA and parC.
Genomic analysis reveals high virulence and antibiotic resistance amongst phage susceptible Acinetobacter baumannii.
The study identified multiple antibiotic resistance genes in phage-susceptible Acinetobacter baumannii strains, including sulfonamide, tetracycline, beta-lactam, aminoglycoside, macrolide, and phenicol resistance genes. These findings highlight the complex resistance profiles of these strains and their potential implications for therapeutic strategies.
A Biological Inventory of Prophages in A. baumannii Genomes Reveal Distinct Distributions in Classes, Length, and Genomic Positions.
The study identifies several antimicrobial resistance (AMR) genes encoded in prophages within Acinetobacter baumannii genomes, including blaOXA-23, blaNDM-1, blaADC-5, blaOXA-67, blaOXA-115, blaTEM-12, aac(3)-I, aac(3)-Id, aacA16, aph(3')-Ia, aph(3')-VI, aph(6)-Id, aph(3'')-Ib, msr(E), mph(E), and sul2. These genes confer resistance to various antibiotics such as carbapenems, penicillins, cephalosporins, monobactams, aminoglycosides, macrolides, and sulfonamides.
Complete Genome Sequencing of Acinetobacter baumannii AC1633 and Acinetobacter nosocomialis AC1530 Unveils a Large Multidrug-Resistant Plasmid Encoding the NDM-1 and OXA-58 Carbapenemases.
The study identifies a large multidrug-resistant plasmid in Acinetobacter baumannii AC1633 and Acinetobacter nosocomialis AC1530 carrying the NDM-1 and OXA-58 carbapenemases, along with other resistance genes such as aac(3)-IId, aph(6)-Id, aph(3")-Ib, sul2, msrE, mphE, and tetA(39).
Characterization of Two Macrolide Resistance-Related Genes in Multidrug-Resistant Pseudomonas aeruginosa Isolates.
The study identified two macrolide resistance genes, mphE and msrE, in multidrug-resistant Pseudomonas aeruginosa isolates. Both genes were functionally validated to confer resistance to multiple macrolide antibiotics, with higher resistance levels observed against second-generation macrolides.
Genomic diversity and molecular epidemiology of Pasteurella multocida.
This study identified several antimicrobial resistance genes in Pasteurella multocida, including aminoglycoside, beta-lactam, tetracycline, macrolide, and sulfonamide resistance genes, highlighting the diverse resistance mechanisms present in this pathogen.
Biosolids as a Source of Antibiotic Resistance Plasmids for Commensal and Pathogenic Bacteria.
Six unique resistance plasmids were identified that can transfer to Salmonella typhimurium, Klebsiella aerogenes, and E. coli, carrying 3-6 antibiotic resistance genes conferring resistance to 2-4 antibiotic classes.
Evaluation of Metagenomic-Enabled Antibiotic Resistance Surveillance at a Conventional Wastewater Treatment Plant.
The study evaluated the resistome in a conventional wastewater treatment plant, identifying several antibiotic resistance genes (ARGs) such as bla OXA-210, bla OXA-212, bla OXA-309, bla OXA-333, qnr S2, sul 1, sul 2, erm B, aac (6′)-Ib7, aac (6′)-Ib8, mph D, msr E, ade J, ade K, mex K, mtr A, sme R, oqx B, qac H, and others. These genes were found to confer resistance to various antibiotics, highlighting the importance of monitoring ARGs in wastewater treatment processes.
A Peek into the Plasmidome of Global Sewage
The study identifies several antimicrobial resistance (AMR) genes in plasmidomes from global sewage samples, highlighting the prevalence of macrolide, lincosamide, streptogramin B, and quinolone resistance genes on plasmids.
Ribosome Protection Proteins-'New' Players in the Global Arms Race with Antibiotic-Resistant Pathogens.
The paper discusses ribosome protection proteins (RPPs) as significant contributors to antibiotic resistance, particularly against tetracyclines, fusidic acid, and various other antibiotics targeting the ribosome. Key RPPs include TetM, TetO, FusB, VgaA, LsaA, MsrE, MsrA, optrA, and poxtA, which confer resistance through mechanisms involving direct interaction with the ribosome and displacement of antibiotics.
Metagenomic analysis of MWWTP effluent treated via solar photo-Fenton at neutral pH: Effects upon microbial community, priority pathogens, and antibiotic resistance genes.
Solar photo-Fenton treatment effectively removed a wide range of antibiotic resistance genes (ARGs) including those conferring resistance to sulfonamides, macrolides, tetracyclines, and beta-lactams. The study identified several ARGs such as sul1, sul2, tet(X), erm(F), mph(A), mph(E), msr(E), aadA, aph(3"), aph(6), strA, and blaBKC.
Emergence of ST63 Pandrug-Resistant Acinetobacter pittii Isolated From an AECOPD Patient in China.
The study reports a pandrug-resistant Acinetobacter pittii isolate (17-84) carrying multiple resistance genes including blaOXA-58, blaPER-1, aph(3')-VIb, aac(3')-IId, sul2, msr(E), and mph(E), along with mutations in gyrA, gyrB, parC, and pmrC contributing to resistance against various antibiotics.
Whole-Genomic Analysis of NDM-5-Producing Enterobacteriaceae Recovered from an Urban River in China.
The study identified multiple antimicrobial resistance genes, including bla NDM-5, bla OXA-10, and bla TEM-1B, in NDM-5-producing Enterobacteriaceae isolates from an urban river in China. These genes conferred resistance to various antibiotics such as carbapenems, cephalosporins, quinolones, and aminoglycosides.
Deciphering Multidrug-Resistant Acinetobacter baumannii from a Pediatric Cancer Hospital in Egypt.
The study identified various AMR genes and mutations in multidrug-resistant Acinetobacter baumannii isolates from a pediatric cancer hospital in Egypt, highlighting the presence of bla NDM, bla OXA-23-like, bla OXA-51-like, and other resistance genes, along with mutations in pmrA and lptF contributing to colistin resistance.
Co-conjugation of Virulence Plasmid and KPC Plasmid in a Clinical Klebsiella pneumoniae Strain.
The study characterizes a carbapenem-resistant hypervirulent Klebsiella pneumoniae strain that harbors a conjugative virulence plasmid and a bla KPC–2-bearing plasmid. The virulence plasmid contains multiple resistance genes, including bla KPC–2, qnrB4, bla DHA–1, sul1, msr(E), mph(E), bla TEM–1B, aac(3)-IId, bla SHV–12, mph(A), bla CTX–M–65, bla TEM–1B, fosA3, and rmtB. The study also shows that these plasmids can be transferred to other bacterial strains, contributing to the spread of multidrug-resistant and hypervirulent K. pneumoniae.
Mouse pneumonia model by Acinetobacter baumannii multidrug resistant strains: Comparison between intranasal inoculation, intratracheal instillation and oropharyngeal aspiration techniques.
The study identified various AMR genes in two multidrug-resistant Acinetobacter baumannii strains, ACC001 and ACC002, including aminoglycoside resistance genes, tetracycline resistance genes, beta-lactamases, and sulfonamide resistance genes. These genes contribute to resistance against multiple antibiotics such as gentamicin, tobramycin, tetracycline, penicillins, cephalosporins, and sulfonamides.
Genotypic and Phenotypic Characterization of Novel Sequence Types of Carbapenem-Resistant Acinetobacter baumannii, With Heterogeneous Resistance Determinants and Targeted Variations in Efflux Operons.
The study identifies various AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii strains, including beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps, contributing to multidrug resistance.
Characterization of a Conjugative Multidrug Resistance IncP-2 Megaplasmid, pPAG5, from a Clinical Pseudomonas aeruginosa Isolate.
The study characterizes a conjugative multidrug resistance IncP-2 megaplasmid, pPAG5, from a clinical Pseudomonas aeruginosa isolate, identifying multiple AMR genes and resistance regions.
Emergence of Carbapenem-Resistant ST244, ST292, and ST2446 Pseudomonas aeruginosa Clones in Burn Patients in Yunnan Province.
Hybrid Plasmids Encoding Antimicrobial Resistance and Virulence Traits Among Hypervirulent Klebsiella pneumoniae ST2096 in India.
The study characterizes hybrid plasmids in MDR-HvKp ST2096 isolates from India, identifying multiple AMR genes such as bla NDM-5, bla OXA-232, aadA2, armA, and others, along with virulence genes like rmpA2 and iucABCD.
Antimicrobial Resistance and Virulence Characteristics of Klebsiella pneumoniae Isolates in Kenya by Whole-Genome Sequencing.
The study identified several AMR genes in K. pneumoniae isolates from Kenya, including blaCTX-M-15, blaTEM-181, blaOXA-181, blaNDM-1, mcr-8, armA, rmtF, aac(6')-Ib-cr, aph(3")-ib, aph(6)-id, dfrA, sul2, qnrB, tetA, and catII, which confer resistance to various antibiotics such as beta-lactams, carbapenems, aminoglycosides, fluoroquinolones, tetracyclines, and chloramphenicol.
Epidemiological and genetic characteristics of clinical carbapenem-resistant Acinetobacter baumannii strains collected countrywide from hospital intensive care units (ICUs) in China.
The study identified multiple AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii (CRAB) strains, highlighting the prevalence of bla OXA-23 and bla OXA-66 as key determinants of carbapenem resistance, along with other resistance mechanisms such as mutations in efflux pump genes and modifications in lipopolysaccharide synthesis.
Occurrence of bla(NDM-1)-Positive Providencia spp. in a Pig Farm of China.
Four bla NDM-1-positive Providencia strains were identified in a pig farm in China, showing multidrug resistance and carrying additional resistance genes such as bla OXA-10, bla TEM-116, and others.
Molecular characterisation of Acinetobacter baumannii isolates from bloodstream infections in a tertiary-level hospital in South Africa.
The study identified colistin-resistant Acinetobacter baumannii isolates with resistance genes including bla OXA-23, bla NDM-1, lps B, and various efflux pumps. These isolates exhibited extensive drug resistance (XDR) and were associated with sequence types ST1 and ST2.
Molecular epidemiology and carbapenem resistance characteristics of Acinetobacter baumannii causing bloodstream infection from 2009 to 2018 in northwest China.
The study identified multiple carbapenem resistance genes, including blaOXA-23 and blaOXA-72, along with other resistance mechanisms such as 16S rRNA methylase armA and aminoglycoside-modifying enzymes. The AdeABC efflux pump was also found to contribute to carbapenem resistance.
Epidemiological links and antimicrobial resistance of clinical Salmonella enterica ST198 isolates: a nationwide microbial population genomic study in Switzerland.
The study identifies several AMR genes and mutations associated with ciprofloxacin resistance in Salmonella enterica ST198 isolates, including aac(3)-Id, aadA7, bla TEM-1b, sul1, tetA, qnrB1, qnrS1, bla CTX-M-14b, bla VEB-8, and bla OXA-48. Additionally, inactivating mutations in ramR and acrB were found to contribute to high-level ciprofloxacin resistance.
Mobile genetic elements in Acinetobacter antibiotic-resistance acquisition and dissemination.
The study highlights the role of mobile genetic elements, particularly insertion sequences (IS), in the acquisition and dissemination of antibiotic resistance in Acinetobacter species. IS elements can enhance the expression of intrinsic beta-lactamase genes, such as bla OXA-23, bla OXA-51, and ampC, leading to carbapenem and cephalosporin resistance. Additionally, IS elements can disrupt genes involved in antibiotic uptake, such as porins, and alter the expression of efflux pumps, contributing to multidrug resistance.
Genomic landscape of prominent XDR Acinetobacter clonal complexes from Dhaka, Bangladesh.
The study identified multiple beta-lactamase genes, including bla OXA-23, bla OXA-66, bla NDM-1, and others, as well as aminoglycoside resistance genes such as aac(3)-Ia, aadA1, and dfrA1, which contribute to the extensive drug resistance in Acinetobacter strains from Bangladesh.
A sludge bulking wastewater treatment plant with an oxidation ditch-denitrification filter in a cold region: bacterial community composition and antibiotic resistance genes.
The study identified several antibiotic resistance genes (ARGs) in a sludge bulking wastewater treatment plant, including sul1, aadA5, ErmF, tet(A), and msrE, which confer resistance to sulfonamide, aminoglycoside, macrolide, tetracycline, and other antibiotics.
Diversity of resistant determinants, virulence factors, and mobile genetic elements in Acinetobacter baumannii from India: A comprehensive in silico genome analysis.
The study identified multiple antibiotic resistance genes (ARGs) in 47 Acinetobacter baumannii isolates from India, including blaOXA-23, blaADC-73, aac(3)-I, aadA, aph(3')-Ib, sul1, sul2, and lpsB. These genes contribute to resistance against carbapenems, cephalosporins, aminoglycosides, sulfonamides, and polymyxins.
Dissemination of Pseudomonas aeruginosa bla(NDM-1)-Positive ST308 Clone in Singapore.
The study identifies multiple antibiotic resistance genes (ARGs) in bla NDM-1 -positive P. aeruginosa ST308 isolates, including aac(3)-Id, aac(6′)-Il, aph(3′)-Iib, bla OXA-488, bla NDM-1, bla PDC-19a, catB7, crpP, fosA, msr(E), qnrVC1, sul2, dfrB5, floR, aadA6, aadA11, and aph(3″)-Ib. These genes confer resistance to various antibiotics such as aminoglycosides, beta-lactams, carbapenems, cephalosporins, chloramphenicol, fluoroquinolones, fosfomycin, macrolides, quinolones, sulfonamides, trimethoprim, and streptomycin.
Genomic epidemiology of nosocomial carbapenemase-producing Citrobacter freundii in sewerage systems in the Helsinki metropolitan area, Finland.
The study identified bla KPC-2 and bla VIM-1 carbapenemase genes, along with various other AMR genes such as aac(6′)-If, aph(6)-Id, aac(3)-IIa, aadA1, dfrA1, sul2, sat2, qnrB, cmlA5, bla OXA-9, bla CMY-79, bla CMY-116, bla TEM-1A, bla CMY-117, bla OXA-10, bla CFE, bla CMY-100, aac(6′)-Ib, aadA2, sul1, qnrS1, qnrB9, mph(E), msr(E), aac(6′)-Iic, and dfrA16 in carbapenemase-producing Citrobacter freundii isolates from hospital environments and municipal wastewater in Finland.
Investigation of multidrug-resistant plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates from Pakistan.
The study identified 34 antimicrobial resistance genes (ARGs) in multidrug-resistant (MDR) plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates in Pakistan, including bla NDM-1, bla OXA-48, and various beta-lactamases, aminoglycoside resistance genes, and others.
Molecular characterization of multidrug resistant Acinetobacter baumannii clinical isolates from Alexandria, Egypt.
The study identified various AMR genes in multidrug-resistant Acinetobacter baumannii isolates from Alexandria, Egypt, including bla OXA-51-like variants, bla OXA-23, bla NDM-1, bla PER-7, bla GES-like, and others, highlighting the widespread resistance to beta-lactams, aminoglycosides, tetracyclines, and other antibiotics.
Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.
The study identified various AMR genes in multidrug-resistant Gram-negative pathogens, highlighting the prevalence of bla CTX-M-15, bla CMY-42, bla NDM-5, aadA, bla TEM-1B, bla OXA-232, bla NDM-1, rmtB, rmtC, bla VEB, bla VIM-2, aph(3'), strA/B, bla OXA-23, aph (3′), catB, dfrB, bla VIM-2, fosA, oqxA, oqxB, bla OXA-23, bla CARB, bla OXA-91, bla OXA-51, bla PAO, bla SHV, aph (3′)-Ib, aph (6)-Id, mphE, msrE, ermB, mphA, aadA, rmtB, qnrB, dfrA, sul1, sul2, and fosA7.
Multidrug-Resistant and Extensively Drug-Resistant Acinetobacter baumannii Causing Nosocomial Meningitis in the Neurological Intensive Care Unit.
The study identified various AMR genes in 37 A. baumannii strains causing nosocomial meningitis, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, macrolide resistance genes, phenicol resistance genes, sulfonamide resistance genes, rifamycin resistance genes, and antiseptic resistance genes.
Genomic characterization of colistin-resistant Klebsiella pneumoniae isolated from intensive care unit patients in Egypt.
The study identifies mcr-1.1 as a plasmid-mediated colistin resistance gene and characterizes several chromosomal mutations in mgrB, arnT, pmrA, pmrB, pmrC, phoQ, and arnB that contribute to colistin resistance in K. pneumoniae isolates from Egypt.
Co-integrate Col3m bla (NDM-1)-harboring plasmids in clinical Providencia rettgeri isolates from Argentina.
The study characterizes bla NDM-1-harboring plasmids in clinical Providencia rettgeri isolates from Argentina, highlighting the presence of various resistance genes such as bla NDM-1, aac(6')-Ib-cr5, aph(3')-Ia, aph(3')-VI, bla PER-2, qnr D1, sul1, sul2, arr3, catB3, floR, mph(E), msr(E), and tet(A).
First Detection and Molecular Characterization of Pseudomonas aeruginosa bla(NDM-1) ST308 in Greece.
The study reports the first detection of blaNDM-1-positive Pseudomonas aeruginosa ST308 in Greece, highlighting the presence of multiple resistance genes including blaNDM-1, blaPAO, blaOXA-10, blaOXA-488, and others, indicating multidrug resistance.
The Molecular Characterization of bla(NDM-1)-Positive Acinetobacter baumannii Isolated in Central Greece.
The study identifies multiple AMR genes in blaNDM-1-positive Acinetobacter baumannii isolates, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, macrolide resistance genes, tetracycline resistance genes, trimethoprim resistance genes, and quaternary ammonium resistance genes.
Tulathromycin metaphylaxis increases nasopharyngeal isolation of multidrug resistant Mannheimia haemolytica in stocker heifers.
The study found that tulathromycin metaphylaxis increased the isolation of multidrug-resistant (MDR) Mannheimia haemolytica (MH) in stocker heifers. MDR MH isolates were associated with integrative conjugative elements (ICE) carrying antimicrobial resistance genes.
Plasmid content of carbapenem resistant Acinetobacter baumannii isolates belonging to five International Clones collected from hospitals of Alexandria, Egypt.
The study characterizes various AMR genes in carbapenem-resistant Acinetobacter baumannii isolates, including blaOXA-23, blaPER-7, blaGES-11, blaGES-35, aph(3')-VI, aac(6')-Ib, sul1, sul2, mph(E), msr(E), armA, strA, strB, cmlA5, arr-2, ant(3'')-II, aadA1-pm, tet(B), tet(39), qacEΔ1, and dfrA7.
Genomic Characterization of a Plasmid-Free and Highly Drug-Resistant Salmonella enterica Serovar Indiana Isolate in China.
The study identifies 54 AMR genes and three AMR gene cassettes in the plasmid-free, highly drug-resistant Salmonella enterica serovar Indiana isolate S1467, contributing to resistance against multiple antimicrobial classes.
Selection and horizontal gene transfer underlie microdiversity-level heterogeneity in resistance gene fate during wastewater treatment.
The study identifies several resistance genes, including mphA, msrE, tet(39), sul1, sul2, mer, qac, and aadA, which were found to be associated with hospital sewage and showed variations in their persistence in activated sludge. These genes contribute to resistance against macrolides, tetracyclines, sulfonamides, mercury, quaternary ammonium compounds, and aminoglycosides.
Metagenomic Investigation of the Short-Term Temporal and Spatial Dynamics of the Bacterial Microbiome and the Resistome Downstream of a Wastewater Treatment Plant in the Iskar River in Bulgaria.
The study identified various antimicrobial resistance genes (ARGs) in the Iskar River downstream of a wastewater treatment plant (WWTP), including genes conferring resistance to macrolides, tetracyclines, beta-lactams, sulfonamides, and carbapenems. Notably, the carbapenemase genes bla OXA-58 and bla IMP-33-like were detected, which are typically associated with clinical settings.
Bacterial Genomics for National Antimicrobial Resistance Surveillance in Cambodia.
The study identified various AMR genes and mutations in bacterial isolates from Cambodia, including extended-spectrum beta-lactamase genes (blaCTX-M-15, blaCTX-M-27, blaCTX-M-55), carbapenemase genes (blaOXA-23, blaNDM-1, blaOXA-58, blaOXA-66), and colistin resistance genes (mcr-1, mcr-3, mcr-7, mcr-9). Additionally, mutations in gyrA (S83F) and parC (S84L) were found to confer fluoroquinolone resistance in Salmonella enterica serovars Paratyphi A and Typhi.
Whole-genome sequencing of two multidrug-resistant acinetobacter baumannii strains isolated from a neonatal intensive care unit in Egypt: a prospective cross-sectional study.
The study identified multidrug-resistant Acinetobacter baumannii strains from a neonatal ICU in Egypt, highlighting the presence of various beta-lactamase genes, aminoglycoside resistance genes, macrolide resistance genes, tetracycline resistance genes, and sulfonamide resistance genes.
Identification and characterisation of colistin-resistant Acinetobacter colistiniresistens co-producing IMP-1 and OXA-58 carbapenemases.
The study identifies and characterizes a colistin-resistant Acinetobacter colistiniresistens isolate co-producing IMP-1 and OXA-58 carbapenemases. The isolate exhibits resistance to multiple antibiotics, including carbapenems, cephalosporins, and polymyxins, and harbors several resistance genes such as blaIMP-1, blaOXA-58, and eptA-like, which contribute to its multidrug-resistant phenotype.
Resistome phylodynamics of multidrug-resistant Shigella isolated from diarrheal patients.
The study identified multiple AMR genes and mutations in multidrug-resistant Shigella strains, including beta-lactamases, macrolide resistance genes, quinolone resistance genes, and chromosomal mutations contributing to fluoroquinolone resistance.
Genomic insights into drug resistance and virulence determinants in rare pyomelanin-producing clinical isolates of Acinetobacter baumannii.
The study identifies several AMR genes including blaOXA-23, blaADC-25, aph(3')-VIa, armA, aph(6)-Id, tet(B), and msr(E) in pyomelanin-producing Acinetobacter baumannii isolates, highlighting their multidrug-resistant profile.
Phenotypic and genotypic characterization of clinical carbapenem-resistant Acinetobacter species harboring the metallo-beta-lactamases IMP-8 or NDM-1 in China.
The study characterized the phenotypic and genotypic features of one IMP-8-producing and four NDM-1-producing plasmids in Acinetobacter spp. strains isolated in 2010, highlighting the presence of various resistance genes including blaIMP-8, blaNDM-1, aac(6')-Ib, aac(3)-IId, msr(E), mph(E), sul1, sul2, tet(39), and aph(3')-VI.
Molecular Epidemiology and In-Depth Characterization of Klebsiella pneumoniae Clinical Isolates from Armenia.
The study identifies multiple AMR genes and mutations in K. pneumoniae isolates from Armenia, highlighting the presence of XDR and MDR strains with resistance to various antibiotics, including carbapenems, aminoglycosides, and quinolones.
Whole-genome sequencing of Acinetobacter baumannii clinical isolates from a tertiary hospital in Terengganu, Malaysia (2011-2020), revealed the predominance of the Global Clone 2 lineage.
The study identified the predominance of the Global Clone 2 lineage of Acinetobacter baumannii in Terengganu, Malaysia, with a focus on the detection of various antimicrobial resistance genes, including bla OXA-23, bla ADC, bla NDM-1, and others, contributing to multidrug resistance.
Retrospective analysis of antimicrobial resistance associated with bovine respiratory disease.
The study identified several clinically relevant antimicrobial resistance genes (ARGs) in bovine respiratory disease (BRD) pathogens, including estT, floR, mphE, erm(42), msrE, aadA, ANT(2''-Ia), APH(3''-Ib), APH(3'-Ia), APH(6)-Id, sul2, tet(H), ROB-1, and OXA-2. Additionally, mutations in gyrA and parC were found to confer resistance to fluoroquinolones in Mannheimia haemolytica.
Genomic epidemiology and antimicrobial resistance of Morganella clinical isolates between 2016 and 2023.
The study identified several AMR genes in Morganella clinical isolates, including tet(B), sul1, catA2, sul2, floR, aadA1, and others, contributing to resistance against various antibiotics.
Circulation of a Unique Klebsiella pneumoniae Clone, ST147 NDM-1/OXA-48, in Two Diverse Hospitals in Calabria (Italy).
The study identifies multiple AMR genes, including bla OXA-48, bla NDM-1, bla CTX-M-15, and bla SHV, in K. pneumoniae strains from two hospitals in Calabria, Italy, highlighting the presence of multidrug-resistant clones.
Fecal carriage and molecular characterization of carbapenem-resistant Enterobacteriaceae from hospitalized children in a tertiary hospital of Shandong, China.
The study identified bla NDM-1, bla NDM-5, and bla OXA-1 as the most prevalent carbapenemase genes in CRE isolates from hospitalized children in Shandong, China. Additional resistance genes such as bla CTX-M-55, bla CTX-M-15, sul 1, tet A, and mcr-1.26 were also characterized.
Integrative and conjugative elements associated with antimicrobial resistance in multidrug resistant Pasteurella multocida isolates from bovine respiratory disease (BRD)-affected animals in Spanish feedlots.
The study identified multiple antimicrobial resistance genes and mutations in multidrug-resistant Pasteurella multocida isolates from bovine respiratory disease-affected animals in Spanish feedlots, highlighting the role of mobile genetic elements in the spread of resistance.
Genomic Characterization of NDM-1 Harboring Extensively-Drug Resistance Klebsiella pneumoniae Isolate From ICU-Admitted Patient With COVID-19.
The study identified multiple antimicrobial resistance genes in an extensively drug-resistant Klebsiella pneumoniae isolate, including bla NDM-1, armA, msrE, mphE, BRP, bla OXA-1, aadA2, dfrA12, qnrB1, bla CTX-M-15, and cat1, highlighting the complex resistance mechanisms in this isolate.
Providencia pseudovermicola sp. nov.: redefining Providencia vermicola and unveiling multidrug-resistant strains from diabetic foot ulcers in Egypt.
The study identifies multiple multidrug-resistant genes in Providencia pseudovermicola sp. nov., including bla CTX-M-14, bla CMY-6, bla NDM-1, qnrD1, aadA, armA, msrE, mphE, lnuF, rmtC, aac(6')-Ib10, sul1, aph(3')-Ia, qacEΔ1, and dfrA1, highlighting the significance of these genes in conferring resistance to various antibiotics.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
The First Case of Antimicrobial-Resistant Salmonella Stanley ST29 Diagnosed Secondary to Acute Cholecystitis.
The study identifies multiple antimicrobial resistance genes in Salmonella Stanley ST29, including beta-lactamases, quinolone resistance genes, macrolide resistance genes, and others, contributing to resistance against various antibiotics.
Diversity versus clonality in carbapenem-resistant A. baumannii: a two-year surveillance study in four intensive care units at a large teaching hospital in Rome, Italy.
The study identified carbapenem-resistant Acinetobacter baumannii isolates carrying the blaOXA-23 gene and aminoglycoside resistance genes such as armA, aadA2, aph(3')-VIa, and ant(2")-Ia. Other resistance genes included mph(E), msr(E), sul1, sul2, and tet(B).
A strain defined as a novel species in the Acinetobacter genus co-harboring chromosomal associated tet(X3) and plasmid associated bla (NDM-1) from a beef cattle farm in Hebei, China.
The study identifies a novel Acinetobacter species co-harboring chromosomal tet(X3) and plasmid-associated bla(NDM-1) genes, demonstrating resistance to multiple antibiotics including carbapenems and tetracyclines.
Genomic Characterization and Antibiotic Resistance Profiles of Acinetobacter baumannii Isolates From Intensive Care Units in Vietnam.
The study identifies multiple AMR genes in three CRAB isolates, including blaOXA-23, blaOXA-66, blaADC-198, blaADC-73, and various aminoglycoside modifying enzymes, efflux pumps, and sulfonamide resistance genes, highlighting the extensive multidrug resistance in these isolates.
Genomic insights into bacteriophages: a new frontier in AMR detection and phage therapy.
The paper discusses the identification of various AMR genes in Acinetobacter baumannii and other pathogens, highlighting their role in resistance to multiple antibiotics and the potential of phage therapy as an alternative treatment.
The genomic configurations driving antimicrobial resistance and virulence in colistin resistant Pseudomonas aeruginosa from an Egyptian Tertiary Oncology Hospital.
The study identified several AMR genes and mutations in colistin-resistant P. aeruginosa isolates, including blaNDM-1, blaOXA-1028, blaOXA-904, and mutations in phoQ and basR genes associated with colistin resistance.
The genomic configurations driving antimicrobial resistance and virulence in colistin resistant Pseudomonas aeruginosa from an Egyptian Tertiary Oncology Hospital.
The study identified several AMR genes and mutations in colistin-resistant P. aeruginosa isolates, including blaNDM-1, blaOXA-1028, blaOXA-904, and mutations in phoQ and basR genes associated with colistin resistance.
Genomic characterization of multidrug-resistant clinical Acinetobacter baumannii isolates from a hospital in Paraguay.
The study identified multiple AMR genes in multidrug-resistant Acinetobacter baumannii isolates from Paraguay, including blaOXA-23, blaOXA-66, blaOXA-65, blaADC-73, blaADC-5, blaTEM-1, and various aminoglycoside, macrolide, sulfonamide, chloramphenicol, tetracycline, and trimethoprim resistance genes.
Dominance of high-risk clones ST2 and ST571 and the diversity of resistance islands in clinical Acinetobacter baumannii isolates from Hanoi, Vietnam.
The study identified high-risk clones ST2 and ST571 in Acinetobacter baumannii isolates from Hanoi, Vietnam, and characterized resistance genes such as blaOXA-23, mph(E), msr(E), and armA, which confer resistance to beta-lactams, macrolides, and aminoglycosides.
Persistent multispecies dissemination of armA-carrying IncR plasmids among clinical and environmental bacterial populations in a Spanish veterinary hospital.
The study identifies the persistent dissemination of armA-carrying IncR plasmids among clinical and environmental bacterial populations in a Spanish veterinary hospital, highlighting the role of these plasmids in the spread of aminoglycoside resistance.
Genomic insights into ST85 and ST158 belonging to recently emerged global clones of multidrug-resistant Acinetobacter baumannii isolates from Egypt: in vitro assessment of repurposed drug-antibiotic combinations.
The study identified multiple antibiotic resistance genes, including blaOXA-23, aadA1, armA, aph(3')-VIa, aph(3')-Ia, and ant(3'')-IIa, in multidrug-resistant Acinetobacter baumannii isolates from Egypt.
Genomic insights into novel ST7947 carbapenem-resistant hypervirulent Klebsiella pneumoniae: a threat from an Indian hospital setting.
The study identifies several AMR genes and mutations in the novel ST7947 carbapenem-resistant hypervirulent Klebsiella pneumoniae isolate BB-7, including bla CTX-M-15, bla SHV-28, bla TEM-1, bla OXA-1, bla OXA-232, armA, aadA2, baeR, tetD, adeF, emrR, AAC(6')-Ib-cr6, catI, sul1, mphE, msrE, dfrA1, oqxA, and fosA, as well as mutations in GyrA, ParC, OmpA, OmpK37, and ArnT that confer resistance to multiple antibiotics.
Global geographic and genomic epidemiology analysis of carbapenem-resistant Escherichia coli carrying bla(NDM-9).
The study characterizes bla NDM-9 -carrying carbapenem-resistant Escherichia coli (CREC) and identifies various antibiotic resistance genes (ARGs) contributing to multidrug resistance. It highlights the role of mobile genetic elements in the dissemination of bla NDM-9 and emphasizes the importance of surveillance for these high-risk clones.
Genomic analysis of multidrug-resistant Salmonellaenterica Serovar Montevideo isolates in China.
The study identified multiple AMR genes in Chinese S. Montevideo isolates, including beta-lactamases (bla TEM−1B, bla OXA−1, bla LAP−2, bla CTX−M−55, bla CTX−M−65, bla DHA−1), quinolone resistance genes (qnrS2, qnrS1, qnrA1, qnrB6, qnrB4, qepA1), macrolide resistance genes (mphA, mphE, msrE, mphB), tetracycline resistance genes (tetA, tetD, tetB), sulfonamide resistance genes (sul1, sul2, dfrA14, dfrA12, dfrA27, sul3), and chloramphenicol resistance genes (floR, catA2, catB3).
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