Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
efflux transporter MtrCDE transcriptional activator MtrA
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G106D | - | - | - | Azithromycin | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|
| MtrA | Card DatabaseReference Gene CatalogReslit | 12 | EFFLUX, Polymyxin b +22 | Neisseria gonorrhoeae +11 | Philadelphia, China, Manitoba, Canada, Arctic, China|Xinjiang, United States|Europe|Russia|Canada|Australia|global | 2012, 2018, 2020, 2023, 2024, 2025 | AF128627.1 | AAD44693.1 |
| mtr | Reslit | 3 | Azithromycin, Tetracycline | Neisseria gonorrhoeae | United States, Europe|Switzerland | 2019, 2021, 2022 | CP012026|CP002422.1|FN995097.1 | - |
| mtrA | Card Database | 1 | - | Neisseria gonorrhoeae | - | - | AF128627.1 | AAD44693.1 |
Dueling regulatory properties of a transcriptional activator (MtrA) and repressor (MtrR) that control efflux pump gene expression in Neisseria gonorrhoeae.
Dueling regulatory properties of a transcriptional activator (MtrA) and repressor (MtrR) that control efflux pump gene expression in Neisseria gonorrhoeae.
Pilot Safety Evaluation of a Novel Strain of Bacteroides ovatus.
The study identified several antibiotic resistance genes in Bacteroides ovatus ELH-B2, including those conferring resistance to tetracycline, erythromycin, aminoglycosides, macrolides, and other antibiotics. These genes were validated through minimum inhibitory concentration (MIC) tests.
Emergence of Neisseria gonorrhoeae Strains Harboring a Novel Combination of Azithromycin-Attenuating Mutations.
The study reports the emergence of Neisseria gonorrhoeae strains harboring a novel combination of azithromycin-attenuating mutations, including the 23S rRNA A2059G mutation and a mosaic-mtr locus, which may confer higher fitness and resistance compared to previously identified isolates.
Investigating hospital Mycobacterium chelonae infection using whole genome sequencing and hybrid assembly.
The study identified potential antimicrobial resistance genes in Mycobacterium chelonae isolates, including LRA-3, erm(38), and mtrA, which may contribute to resistance against imipenem, macrolides, and lincosamides. However, the presence of these genes did not consistently correlate with the observed drug susceptibility profiles.
Molecular characterization of a ceftriaxone-resistant Neisseria gonorrhoeae strain found in Switzerland: a case report.
The study identifies several mutations in genes associated with resistance to ceftriaxone and ciprofloxacin in a Neisseria gonorrhoeae strain from Switzerland, including mutations in penA, porinB, ponA, gyrA, parC, and the 23S rRNA gene.
Canary in the Coal Mine: How Resistance Surveillance in Commensals Could Help Curb the Spread of AMR in Pathogenic Neisseria.
A soft-computation hybrid method for search of the antibiotic-resistant gene in Mycobacterium tuberculosis for promising drug target identification and antimycobacterial lead discovery.
The study identified mtrA and katG as potential drug targets in Mycobacterium tuberculosis. Computational analysis suggested that carvacrol, limonene, p-Coumaric acid prenyl ester, 4-aminocinnamic acid, and 4-nitrocinnamic acid could act as inhibitors against these targets.
Complete genome sequencing and comparative genomic analysis of three donkey Streptococcus equi subsp. equi isolates.
The study identified multiple antibiotic resistance genes in three donkey-derived Streptococcus equi subsp. equi isolates, including genes conferring resistance to beta-lactams, tetracyclines, macrolides, fluoroquinolones, and others. Notably, the HT1112 isolate showed resistance to six antimicrobials, while HTP133 and HTP232 showed resistance to fewer drugs. Additionally, the study highlighted the role of biofilm formation in antimicrobial resistance.
Exploring Nocardia's ecological spectrum and novel therapeutic frontiers through whole-genome sequencing: unraveling drug resistance and virulence factors.
The study identified several antimicrobial resistance genes in Nocardia farcinica, including RbpA, mtrA, FAR-1, rox, blaFAR-1, and blaFAR-1_1, which confer resistance to rifampicin, erythromycin, penicillin, and beta-lactam antibiotics.
Bacterial diversity and resistome analysis of drinking water stored in cisterns from two First Nations communities in Manitoba, Canada.
The study identified a diverse array of antimicrobial resistance genes in drinking water stored in cisterns from two First Nations communities in Manitoba, Canada. Key findings include the presence of genes such as aac(3')-Ia, aac(6')-Iia, aac(6')-Iic, aph(3')-Ia, acrD, smeB, smeR, FEZ-1, rm3, SPG-1, OXA-21, OXA-119, OXA-205, dfrA14, dfrB6, acrB, acrF, adeF, ceoB, emrA, mexE, mexF, mexI, oprN, oqxB, BRP(MBL), vanSO, axyY, CRP, efrB, macB, mexB, mexC, mexD, mexK, mexQ, mexW, mexY, mtrA, muxB, muxC, oleB, oleC, ompB, oprM, smeD, smeE, golS, mdsB, PER-2, TEM-126, msbA, arnA, bacA, bcrA, MCR-5, rosA, rosB, rpoB2, ugd, mexN, taeA, efpA, rphA, rphB, otr(A), otrC, tetA(48 ), ompH, and triC, which confer resistance to various antibiotics including aminoglycosides, beta-lactams, cephalosporins, carbapenems, fluoroquinolones, macrolides, monobactams, nitroimidazoles, peptides, phenicols, pleuromutilins, rifamycins, tetracyclines, and triclosan.
Investigating the resistome of haemolytic bacteria in Arctic soils.
The study identified multiple AMR genes in Arctic haemolytic bacteria, including genes encoding efflux pumps and ribosomal protection proteins, indicating the presence of resistance mechanisms against various antibiotics.
Population genetic analysis of clinical Mycobacterium abscessus complex strains in China.
The study identifies several AMR genes and mutations in M. abscessus complex strains in China, including mtrA, RbpA, bla MAB, erm(41), and erm(46) for resistance to various antibiotics, as well as mutations in rrs, rrl, and gyrA contributing to aminoglycoside, macrolide, and fluoroquinolone resistance.
Virulence and resistance gene analysis of Rothia nasimurium by whole gene sequencing.
The study identified multiple AMR genes in Rothia nasimurium Y1, including vanA, vanC, vanB, vanE, vanD, vanG, vanF, vanM, vanL, vanO, vanN, mtrA, vanRA, arlR, vanRI, vanRB, vanRC, vanRD, vanRF, vanRG, CpxR, kdpE, vanRM, vanRN, baeR, adeR, vanRL, smeR, gyrA, gyrB, parC, Mfd, mfd, PBP2, PBP2x, EF-Tu, dfrE, pncA, tetB(P), tetQ, tet44, tetT, tetW, tetS, tetM, tetO, otr(A), tet36, tet32, clbC, clbB, clbA, cipA, cfrA, cfrC, sul3, ParY, murA, cls, and ileS, which confer resistance to various antibiotics such as glycopeptides, beta-lactams, fluoroquinolones, tetracyclines, sulfonamides, aminoglycosides, lincosamides, phenicols, macrolides, and others.
Global genomic and antimicrobial resistance profiling of Neisseria gonorrhoeae: Insights from whole genome sequencing and minimum inhibitory concentration analysis.
The study identifies key resistance mechanisms in Neisseria gonorrhoeae, including the widespread presence of efflux pump genes (norM, farB, mtrC, mtrA) and specific resistance genes such as bla TEM, tet(C), and erm(C). It highlights the increasing prevalence of antimicrobial resistance and the need for global surveillance and targeted interventions.
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