Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
resistance-nodulation-cell division (RND) antibiotic efflux pump
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| S821A | - | - | - | azithromycin | Reslit | Candidate |
| S23P | - | - | Neisseria gonorrhoeae | cefixime | Reslit | Candidate |
| - | multidrug efflux RND transporter periplasmic adaptor subunit MtrC promoter region | Neisseria gonorrhoeae | azithromycinbeta lactamstetracycline | Reference Gene Catalog | Established | |
| E149C | - | Escherichia coli | tetracyclinevancomycin | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Ngon_mtrC_AZM | Card Database | 1 | Macrolide antibiotic | Neisseria gonorrhoeae | - | - | CP043871.1 | QIH19826.1 |
| MtrC | Card DatabaseReference Gene CatalogReslit | 8 | Efflux, Macrolide antibiotic, Vancomycin, Ciprofloxacin, Penicillin, Cefixime, Ceftriaxone, Azithromycin, Tetracycline, Fluoroquinolones +5 more | Neisseria meningitidis MC58, Escherichia coli, Neisseria gonorrhoeae | Europe, South Africa, United States, Russia, Canada, Australia, global | 1995, 2003, 2013, 2020, 2022, 2025 | AE002098.2 | AAF42063.1 |
A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection.
Research Article
A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection.
Research Article
Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pump.
Research Article
The study identifies the MtrCDE efflux pump components and characterizes the E434K mutation in MtrE as critical for vancomycin resistance, demonstrating that energy-dependent proton translocation is required for pump function.
PARMAP: A Pan-Genome-Based Computational Framework for Predicting Antimicrobial Resistance and Identifying Resistance-Associated Genetic Alterations
Research Article
PARMAP, a pan-genome-based computational framework, successfully predicts antimicrobial resistance in Neisseria gonorrhoeae, Mycobacterium tuberculosis, and Escherichia coli. It identifies both known and novel AMR-associated gene alleles, including mutations in genes like GYRA, GYRB, ACNB, and PDXJ, which are linked to ciprofloxacin resistance.
Assessment of Antibiotic Resistance and Efflux Pump Gene Expression in Neisseria Gonorrhoeae Isolates from South Africa by Quantitative Real-Time PCR and Regression Analysis.
Research Article
The study identified several genes and mutations associated with antibiotic resistance in Neisseria gonorrhoeae isolates from South Africa, including mtrC, gyrA, parE, rpsJ, and 23S rRNA, along with specific mutations in mtrF, gyrA, parC, and macA.
Global genomic and antimicrobial resistance profiling of Neisseria gonorrhoeae: Insights from whole genome sequencing and minimum inhibitory concentration analysis.
Research Article
The study identifies key resistance mechanisms in Neisseria gonorrhoeae, including the widespread presence of efflux pump genes (norM, farB, mtrC, mtrA) and specific resistance genes such as bla TEM, tet(C), and erm(C). It highlights the increasing prevalence of antimicrobial resistance and the need for global surveillance and targeted interventions.
Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system.
Research Article
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