mtrD

membrane transporter component of the MtrC-MtrD-MtrE efflux system

Validation StatusCandidate

Overview

Mechanism: insertional inactivation leading to decreased resistance
Validation Method: genetic analysis and transformation studies
Drug Classes: penicillin, tetracycline
Organisms: Neisseria gonorrhoeae
Papers: 1
Databases: Reslit

Papers1

Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae.

PMID 12270819 · 2002

The study identifies that an mtrR mutation leads to overexpression of the MtrC-MtrD-MtrE efflux pump, which is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae. Additionally, insertional inactivation of mtrD reduces resistance to penicillin and tetracycline.

Gene Information

Gene Name: mtrD
Allele: mtrD
Encodes: membrane transporter component of the MtrC-MtrD-MtrE efflux system
Source Database: Reslit
Mechanism: insertional inactivation leading to decreased resistance
Confers Resistance To: penicillintetracycline
Organisms Tested In: • Neisseria gonorrhoeae
Validation Method: genetic analysis and transformation studies

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mtrD

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