mtrr

transcriptional repressor

Validation StatusCandidate

Overview

Mechanism: regulation of mtrCDE efflux pump
Validation Method: transformation experiments and MIC testing
Drug Classes: azithromycin, penicillin, tetracycline
Organisms: Neisseria gonorrhoeae
Geographic Location: Uruguay
Papers: 2
Databases: Reslit

Papers2

Decreased Azithromycin Susceptibility of Neisseria gonorrhoeae Due to mtrR Mutations

PMID 10508026 · 1999

Mutations in the mtrR gene, including a promoter region deletion and a missense mutation at codon 45, lead to decreased azithromycin susceptibility in Neisseria gonorrhoeae by overexpressing the mtrCDE efflux pump.

Gene Information

Gene Name: mtrr
Allele: mtrR
Encodes: transcriptional repressor
Source Database: Reslit
Mechanism: regulation of mtrCDE efflux pump
Confers Resistance To: azithromycin
Organisms Tested In: • Neisseria gonorrhoeae
Geographic Location: Uruguay
Validation Method: transformation experiments and MIC testing

Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae.

PMID 12270819 · 2002

The study identifies that an mtrR mutation leads to overexpression of the MtrC-MtrD-MtrE efflux pump, which is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae. Additionally, insertional inactivation of mtrD reduces resistance to penicillin and tetracycline.

Gene Information

Gene Name: mtrr
Allele: mtrR
Encodes: transcriptional repressor of MtrCDE expression
Source Database: Reslit
Mechanism: mutation leading to overexpression of MtrC-MtrD-MtrE efflux pump
Confers Resistance To: penicillintetracycline
Organisms Tested In: • Neisseria gonorrhoeae
Validation Method: genetic analysis and transformation studies

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