mupA
mupirocin-resistant isoleucyl-tRNA synthetase
Overview
- Drug Classes
- mupirocin
- Organisms
- Staphylococcus aureus, Coagulase-negative staphylococci, coagulase-negative staphylococci +1 more
- Papers
- 3
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
PMID 11585788 · 2023The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Gene Information
- Gene Name
- mupA
- Allele
- MupA
- Encodes
- mupirocin-resistant isoleucyl-tRNA synthetase
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
Isolation Details
New quadriplex PCR assay for detection of methicillin and mupirocin resistance and simultaneous discrimination of Staphylococcus aureus from coagulase-negative staphylococci.
PMID 15528678 · 2004The study developed a quadriplex PCR assay to detect methicillin and mupirocin resistance in Staphylococcus aureus and coagulase-negative staphylococci, targeting the mecA and mupA genes.
Gene Information
- Gene Name
- mupA
- Allele
- MupA
- Encodes
- isoleucyl-tRNA synthetase that confers resistance to mupirocin
- Validation Method
- PCR assay for the mupA gene
Confers Resistance To
Organisms Tested In
In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis.
PMID 16275681 · 2005The study demonstrates the in vivo transfer of the mupA gene, which confers high-level mupirocin resistance, from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus during mupirocin prophylaxis.
Gene Information
- Gene Name
- mupA
- Allele
- MupA
- Encodes
- alternate isoleucyl-tRNA synthetase
- Validation Method
- plasmid transfer and Southern hybridization
Confers Resistance To
Organisms Tested In
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