murm

MurM (407 amino acids) and MurN (411 amino acids), involved with the addition of the first and second amino acid residues, respectively, to the cell wall precursor stem peptide at the lipid II stage of biosynthesis

Validation StatusCandidate

Overview

Mechanism: regulation of a stress-response pathway that can be triggered by perturbation of cell wall biosynthesis
Validation Method: inactivation of the murMN operon led to elimination of branched peptides from the cell wall and complete loss of penicillin resistance; complementation with various murM alleles restored penicillin resistance
Drug Classes: penicillin
Organisms: Streptococcus pneumoniae
Papers: 1
Databases: Reslit

Papers1

The murMN operon: a functional link between antibiotic resistance and antibiotic tolerance in Streptococcus pneumoniae.

PMID 11830670 · 2002

The murMN operon plays a key role in the regulation of a stress-response pathway that can be triggered by perturbation of cell wall biosynthesis in Streptococcus pneumoniae, affecting both antibiotic resistance and tolerance.

Gene Information

Gene Name: murm
Allele: murM
Encodes: MurM (407 amino acids) and MurN (411 amino acids), involved with the addition of the first and second amino acid residues, respectively, to the cell wall precursor stem peptide at the lipid II stage of biosynthesis
Source Database: Reslit
Mechanism: regulation of a stress-response pathway that can be triggered by perturbation of cell wall biosynthesis
Confers Resistance To: penicillin
Organisms Tested In: • Streptococcus pneumoniae
Validation Method: inactivation of the murMN operon led to elimination of branched peptides from the cell wall and complete loss of penicillin resistance; complementation with various murM alleles restored penicillin resistance

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murm

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