murmn

MurMN resistance determinant

Validation StatusCandidate

Overview

Mechanism: non-PBP-mediated resistance
Validation Method: transformation experiments with cloned pbp genes
Drug Classes: penicillin, amoxicillin
Organisms: Streptococcus pneumoniae
Geographic Location: France|Hungary
Papers: 1
Databases: Reslit

Papers1

Analysis of penicillin-binding protein genes of clinical isolates of Streptococcus pneumoniae with reduced susceptibility to amoxicillin.

PMID 12121904 · 2002

The study identifies mutations in penicillin-binding protein genes (pbp2x, pbp2b, pbp1a) and the murMN resistance determinant as contributors to amoxicillin and penicillin resistance in Streptococcus pneumoniae isolates.

Gene Information

Gene Name: murmn
Allele: murMN
Encodes: MurMN resistance determinant
Source Database: Reslit
Mechanism: non-PBP-mediated resistance
Confers Resistance To: penicillinamoxicillin
Organisms Tested In: • Streptococcus pneumoniae
Geographic Location: France|Hungary
Validation Method: transformation experiments with cloned pbp genes
Sequence Accession: AF468662|AF468663|AF468664|AF468665|AF468666|AF468667|AF467811|AF467812|AF467813|AF467814|AF467815|AF467816|AF467817|AF467818|AF467819|AF467820|AF467821|AF467822

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murmn

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