nadB

l-aspartate oxidase

Validation StatusCandidate

Overview

Mechanism: involved in NAD+ biosynthesis, deletion may lead to silver resistance
Validation Method: chemical genetic screen
Drug Classes: Sulfamethoxazole
Organisms: Escherichia coli
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G123D	-	-	-	Sulfamethoxazole	Reslit	Candidate

Papers2

Using a Chemical Genetic Screen to Enhance Our Understanding of the Antibacterial Properties of Silver.

PMID 29986482 · 2018

This study identifies several genes involved in silver resistance in E. coli through a chemical genetic screen, highlighting the roles of genes related to cell membrane proteins, sulfur metabolism, and NAD+ biosynthesis in conferring resistance to silver.

Gene Information

Gene Name: nadB
Allele: nadB
Encodes: l-aspartate oxidase
Source Database: Reslit
Mechanism: involved in NAD+ biosynthesis, deletion may lead to silver resistance
Organisms Tested In: • Escherichia coli
Validation Method: chemical genetic screen

Browse AMR Genes

nadB

Mutations

Gene Information