Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
intergenic region near efflux pump regulator
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G71E | - | mutations in regulators MexR, NalC, or NalD, up-regulate the mexAB-oprM operon, efflux system transcriptional repressor NalC | Pseudomonas aeruginosa | aztreonamcarbenicillinpiperacillin tazobactam+13 more | Reference Gene CatalogReslit | Confirmed |
| G125D | - | mutations in nalC lead to the overexpression of mexAB-oprM, efflux system transcriptional repressor NalC | Pseudomonas aeruginosa | meropenemaztreonam | Reference Gene CatalogReslit | Confirmed |
| E153Q | - | mutations in regulators MexR, NalC, or NalD | Pseudomonas aeruginosa | levofloxacinciprofloxacingentamicin+3 more | Reslit | Supported |
| S46A | - | - | Pseudomonas aeruginosa | levofloxacin | Reslit | Candidate |
| S209R | - | mutations in regulators MexR, NalC, or NalD, up-regulate the mexAB-oprM operon, efflux system transcriptional repressor NalC | Pseudomonas aeruginosa | carbapenemsciprofloxacinfluoroquinolones+9 more | Reference Gene CatalogReslit | Confirmed |
| A186T | - | - | - | carbapenems | Reslit | Candidate |
| D79E | - | - | Pseudomonas aeruginosa | ciprofloxacinlevofloxacin | Reslit | Candidate |
| G123D | - | - | Pseudomonas aeruginosa | quinolonesbeta lactams | Reslit | Candidate |
| A145V | - | - | - | ciprofloxacinceftazidimemeropenem | Reslit | Candidate |
| F55C | - | - | Pseudomonas aeruginosa | cefiderocol | Reslit | Candidate |
| K58E | - | efflux system transcriptional repressor NalC | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Established |
| S127P | - | efflux system transcriptional repressor NalC | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Established |
| - | - | Pseudomonas aeruginosa | carbenicillinciprofloxacincef | Reslit | Candidate | |
| - | - | Pseudomonas aeruginosa | carbapenemscephalosporinsfluoroquinolones | Reslit | Candidate | |
| - | - | Pseudomonas aeruginosa | carbapenemscephalosporinsfluoroquinolones | Reslit | Candidate | |
| - | - | Pseudomonas aeruginosa | fluoroquinolones | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| nalC/16290-armR | Reslit | 1 | Carbenicillin, Ciprofloxacin, Piperacillin tazobactam | Pseudomonas aeruginosa | - | 2021 | PRJNA542819 | - |
| nal | Reslit | 2 | Nalidixic acid | Salmonella enterica serovar Albany, Campylobacter jejuni, Campylobacter coli | South Korea, Europe, Asia, Africa, North America, South America, Australia, Thailand, Vietnam, China +17 more | 2021 | - | - |
The Genomic Basis of Rapid Adaptation to Antibiotic Combination Therapy in Pseudomonas aeruginosa.
Research Article
The study identifies variants in efflux regulatory systems, including mexR, nalC, and their intergenic regions, as key mechanisms of resistance in Pseudomonas aeruginosa under antibiotic combination therapies.
Clonal dissemination of Salmonella enterica serovar albany with concurrent resistance to ampicillin, chloramphenicol, streptomycin, sulfisoxazole, tetracycline, and nalidixic acid in broiler chicken in Korea.
Research Article
The study identified multiple AMR genes in Salmonella enterica serovar Albany, including ampC, str, tet, sul, nal, and cat, which confer resistance to various antibiotics such as ampicillin, streptomycin, tetracycline, sulfisoxazole, nalidixic acid, and chloramphenicol. These findings highlight the multidrug-resistant nature of S. Albany isolates in Korean broiler chickens.
The worldwide trend of Campylobacter spp., infection from duck-related isolates and associated phenotypic and genotypic antibiotic resistance, since 1985: identifying opportunities and challenges for prevention and control.
Review
The study highlights the widespread presence of Campylobacter spp. in duck-related isolates and reports high resistance rates to fluoroquinolones, tetracycline, and other antibiotics. It emphasizes the need for improved surveillance and control measures to address antimicrobial resistance in Campylobacter.
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