nimA

5-nitroimidazole reductase

Validation StatusCandidate

Overview

Mechanism: confers resistance to metronidazole
Validation Method: PCR and sequencing
Drug Classes: metronidazole
Organisms: Bacteroides fragilis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus
Geographic Location: Europe
Papers: 1
Databases: Reslit

Papers1

Inducible metronidazole resistance and nim genes in clinical Bacteroides fragilis group isolates.

PMID 15728943 · 2005

The study identifies nim genes, including a novel nimF, as mediators of inducible metronidazole resistance in Bacteroides fragilis group isolates, highlighting the clinical significance of these genes in resistance development.

Gene Information

Gene Name: nimA
Allele: NimA
Encodes: 5-nitroimidazole reductase
Source Database: Reslit
Mechanism: confers resistance to metronidazole
Confers Resistance To: metronidazole
Organisms Tested In: • Bacteroides fragilis
• Bacteroides ovatus
• Bacteroides thetaiotaomicron
• Bacteroides vulgatus
Geographic Location: Europe
Validation Method: PCR and sequencing
Sequence Accession: AJ515145

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nimA

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