Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
5-nitroimidazole reductase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| Y130S | - | confers resistance | Clostridioides difficile | metronidazole | Reslit | Candidate |
| L155I | - | confers resistance | Clostridioides difficile | metronidazole | Reslit | Candidate |
| - | constitutive expression of nimB, resulting in metronidazole resistance | Clostridioides difficile | metronidazole | Reslit | Candidate | |
| - | - | Clostridioides difficile | metronidazole | Reslit | Candidate |
Inducible metronidazole resistance and nim genes in clinical Bacteroides fragilis group isolates.
Research Article
The study identifies nim genes, including a novel nimF, as mediators of inducible metronidazole resistance in Bacteroides fragilis group isolates, highlighting the clinical significance of these genes in resistance development.
A study on Nim expression in Bacteroides fragilis.
Research Article
The study demonstrates that NimA, NimB, NimD, and NimE are expressed at the protein level in Bacteroides fragilis and are associated with metronidazole resistance, though no clear correlation between Nim protein levels and resistance levels was observed.
Paraphocaeicola brunensis gen. nov., sp. nov., Carrying Two Variants of nimB Resistance Gene from Bacteroides fragilis, and Caecibacteroides pullorum gen. nov., sp. nov., Two Novel Genera Isolated from Chicken Caeca.
Research Article
The study identifies two novel genera, Paraphocaeicola brunensis and Caecibacteroides pullorum, isolated from chicken caeca. It reports the presence of the nimB resistance gene in Paraphocaeicola brunensis, which confers resistance to metronidazole.
Genomic Insights into Virulence Factors and Multi-Drug Resistance in Clostridium perfringens IRMC2505A.
Research Article
The study identifies multiple antimicrobial resistance genes in the multidrug-resistant Clostridium perfringens IRMC2505A strain, including NimB, TetB(P), fabV, TetA(P), gidB, FabK-like, and mprF, which confer resistance to tetracycline and defensin-like cationic antimicrobial peptides.
Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile.
Research Article
The study identifies nimB as a heme-dependent 5-nitroimidazole reductase that confers metronidazole resistance in Clostridioides difficile. A T-to-G mutation in the promoter region of nimB leads to constitutive expression, resulting in resistance. This mutation is associated with fluoroquinolone resistance due to a Thr82Ile substitution in GyrA.
Newly emerging metronidazole-resistant Clostridioides difficile PCR ribotype 955 identified in Poland, 2021 to 2023 but not in Czechia, 2012 to 2023 and Slovakia, 2015 to 2023.
Research Article
The study identified metronidazole-resistant Clostridioides difficile PCR ribotype 955 in Poland, with resistance mechanisms involving mutations in the nimB gene and its promoter.
Reversion of heme-dependent metronidazole resistance in Clostridioides difficile.
Research Article
Artemisinin (ART) was identified as an adjuvant capable of resensitizing heme-dependent metronidazole (MTZ) non-susceptible Clostridioides difficile and Bacteroides fragilis by reducing intracellular hemin levels and reversing nimB-mediated resistance.
A severe Clostridioides difficile ribotype 027 infection in Beijing, China, july 2024.
Research Article
The study identified vancomycin resistance mediated by a mutation in the VanR gene and metronidazole resistance associated with the nimB gene in a Clostridioides difficile ribotype 027 isolate.
Nucleotide sequence analysis of two 5-nitroimidazole resistance determinants from Bacteroides strains and of a new insertion sequence upstream of the two genes.
Research Article
Nucleotide sequence analysis of two 5-nitroimidazole resistance determinants from Bacteroides strains and of a new insertion sequence upstream of the two genes.
Research Article
Nucleotide sequence analysis of two 5-nitroimidazole resistance determinants from Bacteroides strains and of a new insertion sequence upstream of the two genes.
Research Article
Nucleotide sequence analysis of two 5-nitroimidazole resistance determinants from Bacteroides strains and of a new insertion sequence upstream of the two genes.
Research Article
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