Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ResLit

nimI

nitroimidazole reductase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to nimI

AMR Rules

Browse AMR rules for nimI

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic inactivation
Validation Method: DNA sequence analysis and PCR
Drug Classes: Metronidazole, METRONIDAZOLE, NITROIMIDAZOLE
Organisms: Prevotella baroniae, Bacteroides fragilis, Segatella baroniae, Segatella baroniae F0067
Geographic Location: France
Alleles: 2
Papers: 1
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
NimI	Card DatabaseReference Gene CatalogReslit	3	Metronidazole, NITROIMIDAZOLE	Prevotella baroniae +2	France	2010	FJ940883\|FJ940875\|FJ940876\|FJ940877\|FJ940878\|FJ940879\|FJ940880\|FJ940881\|FJ940882

Papers1

Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae.

PMID 19805556 · 2010

The study describes a new nitroimidazole resistance gene, nimI, in Prevotella baroniae, which is intrinsic to the species and can confer resistance to metronidazole upon prolonged exposure.

Gene Information

Gene Name: nimI
Allele: NimI
Encodes: nitroimidazole reductase
Source Database: Reslit
Confers Resistance To: Metronidazole
Organisms Tested In: • Prevotella baroniae
• Bacteroides fragilis
Geographic Location: France
Validation Method: DNA sequence analysis and PCR
Sequence Accession: FJ940883|FJ940875|FJ940876|FJ940877|FJ940878|FJ940879|FJ940880|FJ940881|FJ940882

Metronidazole resistance in Prevotella spp. and description of a new nim gene in Prevotella baroniae.

PMID 19805556 · 2010

Gene Information

Gene Name: nimI
Allele: nimI
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: METRONIDAZOLE
Organisms Tested In: • Segatella baroniae
Sequence Accession: FJ940883, FJ940884, FJ940886, FJ940887, FJ940889
Notes: likely also resistance to tinidazole, nimorazole, dimetridazole, 6-Amino PA824, ornidazole, megazol, azanidazole

PMID N/A

Gene Information

Gene Name: nimI
Allele: NimI
Encodes: 5-nitroimidazole reductase NimI
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: NITROIMIDAZOLE
Organisms Tested In: • Segatella baroniae F0067
Sequence Accession: AWEY01000007.1
Protein Accession: ERK40265.1
Notes: ARO:3007111

PMID N/A

Gene Information

Gene Name: nimI
Allele: NimI
Encodes: 5-nitroimidazole reductase NimI
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: NITROIMIDAZOLE
Organisms Tested In: • Segatella baroniae F0067
Sequence Accession: AWEY01000007.1
Protein Accession: ERK40265.1
Notes: ARO:3007111

PMID N/A

Gene Information

Gene Name: nimI
Allele: nimI
Encodes: nitroimidazole reductase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Segatella baroniae F0067
Sequence Accession: AWEY01000007.1
Protein Accession: ERK40265.1
Notes: ARO:3007111