nimK

5-nitroimidazole reductase NimK

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: whole-genome sequencing and protein sequence analysis
Drug Classes: Nitroimidazole, Metronidazole, Nitroimidazole antibiotic
Organisms: Prevotella bivia
Geographic Location: Japan
Papers: 2
Databases: Card DatabaseReference Gene CatalogReslit

Papers2

Gene Information

Gene Name: nimK
Allele: NimK
Encodes: 5-nitroimidazole reductase NimK
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: NITROIMIDAZOLE
Organisms Tested In: • Prevotella bivia
Sequence Accession: MG827401.1
Protein Accession: AXA20009.1
Notes: ARO:3007113

Three metronidazole-resistant Prevotella bivia strains harbour a mobile element, encoding a novel nim gene, nimK, and an efflux small MDR transporter.

Research Article

PMID 29982676 · 2018

The study identifies a novel nim gene, nimK, in three metronidazole-resistant Prevotella bivia strains, located on a mobile genetic element (MGE) along with an efflux SMR transporter.

Gene Information

Gene Name: nimK
Allele: NimK
Encodes: nitroimidazole antibiotic resistance protein
Source Database: Reslit
Confers Resistance To: metronidazole
Organisms Tested In: • Prevotella bivia
Validation Method: whole-genome sequencing and protein sequence analysis
Sequence Accession: MG827401

PMID 29982676

Gene Information

Gene Name: nimK
Allele: NimK
Encodes: 5-nitroimidazole reductase NimK
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: NITROIMIDAZOLE
Organisms Tested In: • Prevotella bivia
Sequence Accession: MG827401.1
Protein Accession: AXA20009.1
Notes: ARO:3007113

PMID 29982676

Gene Information

Gene Name: nimK
Allele: nimK
Encodes: nitroimidazole reductase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: NITROIMIDAZOLENITROIMIDAZOLE ANTIBIOTIC
Organisms Tested In: • Prevotella bivia
Sequence Accession: MG827401.1
Protein Accession: AXA20009.1
Notes: ARO:3007113

The emergence of metronidazole-resistant Prevotella bivia harboring nimK gene in Japan.

Research Article

PMID 39162532 · 2024

The study identifies the first metronidazole-resistant Prevotella bivia strain (TOH-2715) carrying the nimK gene, highlighting the emergence of nimK in anaerobic bacteria and its potential for horizontal gene transfer.

Gene Information

Gene Name: nimK
Allele: NimK
Encodes: nitro-imidazole reductase
Source Database: Reslit
Confers Resistance To: metronidazole
Organisms Tested In: • Prevotella bivia
Geographic Location: Japan
Validation Method: PCR and WGS analysis
Sequence Accession: MG827401.1|NZ_ADFO01000000|CP126676.1|CP126677.1|CAMULN010000003|QENY00000000.1|SRR10258545_bin.4_metaWRAP_v1.3_MAG|ERR9530650_bin.3_metaWRAP_v1.3_MAG

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nimK

5-nitroimidazole reductase NimK

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to nimK

AMR Rules

Browse AMR rules for nimK

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: whole-genome sequencing and protein sequence analysis
Drug Classes: Nitroimidazole, Metronidazole, Nitroimidazole antibiotic
Organisms: Prevotella bivia
Geographic Location: Japan
Papers: 2
Databases: Card DatabaseReference Gene CatalogReslit

Papers2

PMID N/A

Gene Information

Gene Name: nimK
Allele: NimK
Encodes: 5-nitroimidazole reductase NimK
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: NITROIMIDAZOLE
Organisms Tested In: • Prevotella bivia
Sequence Accession: MG827401.1
Protein Accession: AXA20009.1
Notes: ARO:3007113

Three metronidazole-resistant Prevotella bivia strains harbour a mobile element, encoding a novel nim gene, nimK, and an efflux small MDR transporter.

Research Article

PMID 29982676 · 2018

The study identifies a novel nim gene, nimK, in three metronidazole-resistant Prevotella bivia strains, located on a mobile genetic element (MGE) along with an efflux SMR transporter.

Gene Information

Gene Name: nimK
Allele: NimK
Encodes: nitroimidazole antibiotic resistance protein
Source Database: Reslit
Confers Resistance To: metronidazole
Organisms Tested In: • Prevotella bivia
Validation Method: whole-genome sequencing and protein sequence analysis
Sequence Accession: MG827401

PMID 29982676

Gene Information

Gene Name: nimK
Allele: NimK
Encodes: 5-nitroimidazole reductase NimK
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: NITROIMIDAZOLE
Organisms Tested In: • Prevotella bivia
Sequence Accession: MG827401.1
Protein Accession: AXA20009.1
Notes: ARO:3007113

PMID 29982676

Gene Information

Gene Name: nimK
Allele: nimK
Encodes: nitroimidazole reductase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: NITROIMIDAZOLENITROIMIDAZOLE ANTIBIOTIC
Organisms Tested In: • Prevotella bivia
Sequence Accession: MG827401.1
Protein Accession: AXA20009.1
Notes: ARO:3007113

The emergence of metronidazole-resistant Prevotella bivia harboring nimK gene in Japan.

Research Article

PMID 39162532 · 2024

Gene Information

Gene Name: nimK
Allele: NimK
Encodes: nitro-imidazole reductase
Source Database: Reslit
Confers Resistance To: metronidazole
Organisms Tested In: • Prevotella bivia
Geographic Location: Japan
Validation Method: PCR and WGS analysis
Sequence Accession: MG827401.1|NZ_ADFO01000000|CP126676.1|CP126677.1|CAMULN010000003|QENY00000000.1|SRR10258545_bin.4_metaWRAP_v1.3_MAG|ERR9530650_bin.3_metaWRAP_v1.3_MAG

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No comments yet. Be the first to comment!

nimK

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nimK

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