norB

efflux pump

Validation StatusCandidate

Overview

Validation Method: overexpression in S. aureus and MIC testing
Drug Classes: quinolones, ethidium bromide, cetrimide, sparfloxacin, moxifloxacin, tetracycline
Organisms: Staphylococcus aureus
Papers: 1
Databases: Reslit

Papers1

MgrA Is a Multiple Regulator of Two New Efflux Pumps in Staphylococcus aureus

PMID 15774883 · 2005

The study identifies two novel efflux pumps, NorB and Tet38, in Staphylococcus aureus, which confer resistance to quinolones and tetracycline, respectively. MgrA negatively regulates the expression of these pumps.

Gene Information

Gene Name: norB
Allele: norB
Encodes: efflux pump
Source Database: Reslit
Confers Resistance To: quinolonesethidium bromidecetrimidesparfloxacinmoxifloxacintetracycline
Organisms Tested In: • Staphylococcus aureus
Validation Method: overexpression in S. aureus and MIC testing

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norB

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