nuoC

NADH:quinone oxidoreductase subunit CD

Validation StatusCandidate

Overview

Validation Method: Mutation analysis and MIC values
Drug Classes: Cefiderocol
Organisms: Escherichia coli
Geographic Location: China
Papers: 1
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
F562Y	-	-	Escherichia coli	Cefiderocol	Reslit	Candidate

Papers1

In vitro antimicrobial activity and resistance mechanisms of cefiderocol against clinical carbapenem-resistant gram-negative bacteria.

PMID 41113641 · 2025

Cefiderocol showed high in vitro activity against carbapenem-resistant gram-negative bacteria, with resistance mechanisms involving beta-lactamase genes (bla OXA-66, bla OXA-23, bla SHV-12), mutations in envZ, cirA, nuoC, and ampC, and loss or altered expression of iron transporter genes (piuA, pirA, fepA).

Gene Information

Gene Name: nuoC
Allele: nuoC
Encodes: NADH:quinone oxidoreductase subunit CD
Source Database: Reslit
Confers Resistance To: Cefiderocol
Organisms Tested In: • Escherichia coli
Geographic Location: China
Validation Method: Mutation analysis and MIC values
Sequence Accession: JBBXJG000000000|JBBXHS000000000|JBBXIN000000000|JBBXHW000000000|JBBXJJ000000000|JBBXJK000000000|JAVIKM000000000|JAVIKS000000000|JAVILL000000000|JAVILM000000000|JAVILT000000000|JAVIMK000000000|JAVIML000000000|JAVIMM000000000|JANWRX000000000|JANWPI000000000|JANWQC000000000|JANWPL000000000|JANWPJ000000000|JANWOY000000000|JANWOK000000000|JANWOH000000000|JANWMY000000000|VEON00000000|RZKE00000000|PRJNA882512

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nuoC

Mutations

Gene Information