Browse AMR Genes

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ResLit

oatA

O-acetyltransferase A

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to oatA

AMR Rules

Browse AMR rules for oatA

Validation StatusSupported

Overview

Mechanism: O-acetylation of peptidoglycan
Validation Method: susceptibility testing of mutants
Drug Classes: Nafcillin
Organisms: Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Streptococcus suis, Xenorhabdus nematophila, Escherichia coli
Papers: 6
Databases: Reslit
Mutations: 4

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G451S	-	-	Staphylococcus aureus	Nafcillin	Reslit	Candidate
-	1239-1250del	-	Staphylococcus aureus	Nafcillin	Reslit	Candidate
-	1327del	-	Staphylococcus aureus	Nafcillin

Papers6

Molecular basis of resistance to muramidase and cationic antimicrobial peptide activity of lysozyme in staphylococci.

PMID 17676995 · 2007

The study identifies oatA, graRS, and dltA as genes involved in resistance to lysozyme and cationic antimicrobial peptides in Staphylococcus aureus.

Gene Information

Gene Name: oatA
Allele: oatA
Encodes: O-acetyltransferase A
Source Database: Reslit
Mechanism: O-acetylation of peptidoglycan
Organisms Tested In: • Staphylococcus aureus
Validation Method: susceptibility testing of mutants

The extracytoplasmic function sigma factor SigV plays a key role in the original model of lysozyme resistance and virulence of Enterococcus faecalis.

PMID 20300180 · 2010

SigV, oatA, and dltA are involved in lysozyme resistance and virulence of Enterococcus faecalis. SigV plays a key role in the lysozyme resistance mechanism, and its deletion leads to increased sensitivity to lysozyme. OatA and dltA also contribute to lysozyme resistance, with their combined deletion causing the highest sensitivity. Additionally, SigV is crucial for the virulence of E. faecalis in both systemic and urinary tract infection models.

Gene Information

Gene Name: oatA
Allele: oatA
Encodes: O-acetyltransferase
Source Database: Reslit
Mechanism: modification of peptidoglycan structure
Organisms Tested In: • Enterococcus faecalis
Validation Method: mutant analysis

The Bacillus subtilis extracytoplasmic function σ factor σ(V) is induced by lysozyme and provides resistance to lysozyme.

PMID 21856855 · 2011

The study identifies oatA as a gene that confers resistance to lysozyme in Bacillus subtilis, and shows that its expression is induced by lysozyme stress through the σV factor.

Gene Information

Gene Name: oatA
Allele: oatA
Encodes: O-acetyltransferase
Source Database: Reslit
Organisms Tested In: • Bacillus subtilis
Validation Method: mutant analysis and complementation

Lysozyme resistance in Streptococcus suis is highly variable and multifactorial.

PMID 22558419 · 2012

The study identifies oatA, SSU0475, and SSU0519 as genes involved in lysozyme resistance in Streptococcus suis, with experimental validation through mutant construction and MIC testing.

Gene Information

Gene Name: oatA
Allele: oatA
Encodes: peptidoglycan O-acetyltransferase
Source Database: Reslit
Organisms Tested In: • Streptococcus suis
Validation Method: mutant construction and MIC testing

The Odilorhabdin Antibiotic Biosynthetic Cluster and Acetyltransferase Self-Resistance Locus Are Niche and Species Specific.

PMID 35012352 · 2022

The study identifies the oatA gene as responsible for self-resistance to odilorhabdins in Xenorhabdus nematophila. OatA, an N-acetyltransferase, acetylates the side chain amino group of odilorhabdin, leading to loss of antibacterial activity.

Gene Information

Gene Name: oatA
Allele: oatA
Encodes: Gcn5-related N-acetyltransferase
Source Database: Reslit
Mechanism: self-resistance to odilorhabdins
Organisms Tested In: • Xenorhabdus nematophila
• Escherichia coli
Validation Method: cloning and expression in E. coli, in vitro acetylation, LC-MS/MS analysis
Sequence Accession: CP053420