The study identifies OmpK35 and OmpK36 as major porins in Klebsiella pneumoniae that facilitate the efficient diffusion of β-lactams, with OmpK35 showing higher permeability compared to its E. coli homologs OmpF and OmpC. Deletion of ompK35 significantly increased MICs of various β-lactams, highlighting its critical role in drug entry.

The study introduces Kleborate, a tool for analyzing genomes of Klebsiella pneumoniae and its related species complex, focusing on AMR and virulence determinants. Key findings include the identification of SHV beta-lactamase, OmpK35 and OmpK36 porins, and MgrB/PmrB regulators as critical factors in carbapenem and colistin resistance.

The study identifies bla KPC-3, bla KPC-2, bla OXA-232, and mutations in ompK35, ompK36, and ompK37 as significant contributors to carbapenem resistance in Klebsiella pneumoniae isolates.

The study identifies the acquisition of multiple AMR genes and mutations in a Klebsiella pneumoniae clone, leading to increased multidrug resistance. Key findings include the role of blaCTX-M-14, aac(3)-Iid, tet(A), qnrS1, sul1, dfrA1, acrAB-TolC, ompK35, and mgrB in conferring resistance to various antibiotics, along with mutations in ramR that contribute to resistance.

Relebactam restored imipenem susceptibility in K. pneumoniae isolates with bla KPC and AmpC but not in those with MBLs. Impaired porin expression and efflux pump activity contributed to imipenem resistance.

The study identifies increased blaKPC copy number and truncation of OmpK35 and OmpK36 porins as mechanisms of resistance to Imipenem/Relebactam and Meropenem/Vaborbactam in a KPC-producing Klebsiella pneumoniae clinical isolate.

The study identifies ompK35 and ompK36 porin mutations, blaKPC β-lactamase, and acrB efflux pump as key mechanisms of resistance to MER-VAB, IMI-REL, and CAZ-AVI in KPC-producing Enterobacterales and Pseudomonas aeruginosa.

The study identified bla KPC, bla OXA-48, bla NDM-1, and bla IMP as the primary genes responsible for ceftazidime/avibactam resistance in carbapenem-resistant Klebsiella pneumoniae isolates from cancer patients. Additionally, the absence of ompK35 and ompK36 was associated with resistance.

This review discusses proteomic approaches for diagnosing antibiotic resistance in ESKAPE pathogens, highlighting the importance of proteomic techniques in understanding resistance mechanisms and improving diagnostic accuracy.

The study identifies several AMR genes and mutations in Klebsiella pneumoniae that contribute to resistance against carbapenems, ceftazidime/avibactam, tigecycline, and colistin. Key findings include the acquisition of blaKPC and blaNDM harboring plasmids, specific mutations in blaKPC, porin deficiencies (ompK35 and ompK36), overexpression of efflux pumps (acrAB, oqxAB), and mutations in rpsJ, ramR, tetA, mgrB, and pmrB.

The study identifies multiple carbapenemase genes (blaKPC, blaNDM, blaOXA-48-like) and the mcr-1 gene, which confer resistance to carbapenems and polymyxin, respectively. Mutations in maeB and exuT are associated with resistance, survival, or proliferation in K. pneumoniae strains.

TolC is required for antimicrobial resistance, capsule production, and virulence in K. pneumoniae. Mutations in tolC lead to increased susceptibility to multiple antibiotics and impair capsule production and biofilm formation.

The study identifies the blaNDM-1 gene and various other resistance genes in multidrug-resistant Klebsiella pneumoniae ST147 strains, highlighting their role in carbapenem resistance and hypervirulence.

The study characterizes various AMR genes and mutations in Enterobacterales and Pseudomonas aeruginosa, including bla CTX-M-15, bla OXA-1, bla OXA-181, bla OXA-48, bla NDM-1, bla KPC-3, bla VIM-2, ampC, cmrA, mexAB-OprM, mexXY-OprM, oprD, ompK35, ompK36, and ftsI, which confer resistance to cefepime and carbapenems.

The study identifies multiple AMR genes and mutations in K. pneumoniae isolates from Armenia, highlighting the presence of XDR and MDR strains with resistance to various antibiotics, including carbapenems, aminoglycosides, and quinolones.

The study identified multiple AMR genes including acrAB, tolC, mdtK, ompK35, and ompK36 in Klebsiella pneumoniae isolates from North Iran, which were associated with resistance to various antibiotics.

The study identifies blaNDM-1 as a gene conferring resistance to cefepime and meropenem, and highlights the role of ompK35 and ompK36 porin deletions in reducing susceptibility to these antibiotics in Klebsiella pneumoniae.

The study shows that meropenem resistance in Klebsiella quasipneumoniae ATCC 700603 is primarily due to the production of carbapenemases, with the class D carbapenemase encoding gene bla OXA-2 being significantly over-expressed in the resistant strain.

The study identified various carbapenemase genes (blaKPC-2, blaKPC-3, blaOXA-181, blaOXA-232, blaOXA-48, blaNDM-1, blaNDM-4, blaNDM-7, blaIMP-1) and extended-spectrum beta-lactamase genes (ampC, ctx-M-15, shv-9) in carbapenem-resistant Klebsiella pneumoniae isolates. Additionally, mutations in porin genes ompK35 and ompK36 were found to contribute to carbapenem resistance in isolates lacking carbapenemases.

The study identifies blaKPC-2, blaOXA-1, blaCTX-M-15, SHV-182, ompK35, and ompK36 as key resistance genes in carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) isolates in China, highlighting their role in resistance to carbapenems and other antibiotics.

The paper reviews molecular resistance mechanisms to newly approved antibiotics in WHO priority pathogens, identifying various beta-lactamases, efflux pumps, and target site modifications that confer resistance.