Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
General Bacterial Porin with reduced permeability to beta-lactams
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| R239K | - | - | Klebsiella pneumoniae | ceftazidimeavibactamcarbapenems | ResFinder DatabaseReslit | Confirmed |
| E244D | - | - | Klebsiella pneumoniae | ceftazidimeavibactamcarbapenems | ResFinder DatabaseReslit | Confirmed |
| N274S | - | - | Klebsiella pneumoniae | ceftazidimeavibactamcarbapenems | ResFinder DatabaseReslit | Confirmed |
| D275T | - | - | Klebsiella pneumoniae | ceftazidimeavibactamcarbapenems | ResFinder DatabaseReslit | Confirmed |
| V277I | - | - | Klebsiella pneumoniae | ceftazidimeavibactamcarbapenems | ResFinder DatabaseReslit | Confirmed |
| V295G | - | - | Klebsiella pneumoniae | ceftazidimeavibactam | Reslit | Candidate |
| D350G | - | - | Klebsiella pneumoniae | ceftazidimeavibactam | Reslit | Candidate |
| R345H | - | - | Klebsiella pneumoniae | ceftazidimeavibactam | Reslit | Candidate |
| N230G | - | - | Klebsiella pneumoniae | ceftazidimeavibactamcarbapenems+1 more | ResFinder DatabaseReslit | Confirmed |
| M232Q | - | - | Klebsiella pneumoniae | ceftazidimeavibactam | Reslit | Candidate |
| T233H | - | - | Klebsiella pneumoniae | ceftazidimeavibactam | Reslit | Candidate |
| Q234Y | - | - | Klebsiella pneumoniae | ceftazidimeavibactam | Reslit | Candidate |
| R238K | - | - | Klebsiella pneumoniae | ceftazidimeavibactam | Reslit | Candidate |
| E243D | - | - | Klebsiella pneumoniae | ceftazidimeavibactam | Reslit | Candidate |
| D274T | - | - | Klebsiella pneumoniae | ceftazidimeavibactam | Reslit | Candidate |
| I70M | - | - | Klebsiella pneumoniae | carbapenemscephalosporinsmeropenem | ResFinder DatabaseReslit | Confirmed |
| I128M | - | - | Klebsiella pneumoniae | carbapenemscephalosporins | ResFinder DatabaseReslit | Confirmed |
| T261A | - | - | - | carbapenems | Reslit | Candidate |
| N106S | - | - | Citrobacter freundii | carbapenems | Reslit | Candidate |
| P170M | - | - | Klebsiella pneumoniae | carbapenemscephalosporins | Reslit | Candidate |
| V164A | - | - | - | carbapenems | Reslit | Candidate |
| G156D | - | - | - | carbapenems | Reslit | Candidate |
| A261T | - | - | Klebsiella pneumoniae | carbapenemsaztreonamcephalosporins | Reslit | Candidate |
| I128K | - | - | Klebsiella pneumoniae | meropenem | Reslit | Candidate |
| M233Q | - | - | Klebsiella pneumoniae | carbapenems | ResFinder Database | Established |
| T234H | - | - | Klebsiella pneumoniae | carbapenems | ResFinder Database | Established |
| Q235Y | - | - | Klebsiella pneumoniae | carbapenems | ResFinder Database | Established |
| N237H | - | - | Klebsiella pneumoniae | carbapenems | ResFinder Database | Established |
| ins238TERY | - | - | Klebsiella pneumoniae | carbapenems | ResFinder Database | Established |
| ins275SSTNGG | - | - | Klebsiella pneumoniae | carbapenems | ResFinder Database | Established |
| - | - | Klebsiella pneumoniae | carbapenems | Reslit | Candidate | |
| - | - | Klebsiella pneumoniae | carbapenems | Reslit | Candidate | |
| - | - | Klebsiella pneumoniae | carbapenems | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Kpne_OmpK37 | Card Database | 1 | Monobactam, Carbapenem, Penicillin beta-lactam, Cephalosporin | Klebsiella pneumoniae | - | - | AJ011502.1 | CAA09666.1 |
| ompK37 | Reslit | 11 | Beta lactams, Ertapenem, Cefotaxime, Ceftazidime, Cefoxitin, Ampicillin, Imipenem, Meropenem, Cephalosporins, Carbapenems +1 more | Klebsiella pneumoniae, Klebsiella variicola | Pakistan, UK, Europe, Romania, China, Armenia, Bangladesh | 1999, 2020, 2021, 2022, 2024, 2025 | AJ011502 | - |
Identification and characterization of a new porin gene of Klebsiella pneumoniae: its role in beta-lactam antibiotic resistance.
Research Article
The study identifies and characterizes a new porin gene, ompK37, in Klebsiella pneumoniae, which contributes to beta-lactam antibiotic resistance by reducing the penetration of these antibiotics due to a narrower pore compared to other porins.
Global Trends in Proteome Remodeling of the Outer Membrane Modulate Antimicrobial Permeability in Klebsiella pneumoniae.
Research Article
Loss of OmpK35 and OmpK36 porins significantly increases resistance to β-lactam antibiotics in Klebsiella pneumoniae. The study identifies OmpK38 as a new member of the general bacterial porin family and demonstrates that porin remodeling plays a critical role in antimicrobial resistance.
Preterm infants harbour diverse Klebsiella populations, including atypical species that encode and produce an array of antimicrobial resistance- and virulence-associated factors.
Research Article
The study identified various antimicrobial resistance genes in Klebsiella isolates from preterm infants, highlighting the presence of multidrug resistance mechanisms.
Fecal Klebsiella pneumoniae Carriage Is Intermittent and of High Clonal Diversity.
Research Article
The study identified 25 antibiotic resistance genes in 80 Klebsiella pneumoniae isolates, primarily encoding efflux pumps and inactivating enzymes. Notably, blaSHV, emrB, emrR, marA, marR, msbA, ompK37, oqxA, oqxB, acrA, vgaC, fosA, tet(D), APH(3")-Ib, APH(6)-Id, aadA, qnrS2, rpoB2, mexF, and oprN were found to confer resistance to various antibiotics.
Genomic Features Associated with the Degree of Phenotypic Resistance to Carbapenems in Carbapenem-Resistant Klebsiella pneumoniae.
Research Article
The study identifies bla KPC-3, bla KPC-2, bla OXA-232, and mutations in ompK35, ompK36, and ompK37 as significant contributors to carbapenem resistance in Klebsiella pneumoniae isolates.
Characterization of Carbapenemase-Producing Klebsiella pneumoniae Isolates from Two Romanian Hospitals Co-Presenting Resistance and Heteroresistance to Colistin.
Research Article
The study identifies multiple AMR genes and mutations in carbapenemase-producing Klebsiella pneumoniae isolates, including bla NDM-1, bla OXA-48, and various aminoglycoside-modifying enzymes, as well as mutations in mgrB, gyrA, parC, and porin genes associated with colistin and fluoroquinolone resistance.
A novel approach for combining the metagenome, metaresistome, metareplicome and causal inference to determine the microbes and their antibiotic resistance gene repertoire that contribute to dysbiosis.
Research Article
The study identifies specific antibacterial resistance (ABR) genes that may contribute to exponential cell division in the presence of antibiotics for various pathogens, including Klebsiella pneumoniae, Citrobacter freundii, Staphylococcus epidermidis, Veillonella parvula, and Clostridium perfringens.
Hypermucoviscous Multidrug-Resistant Klebsiella variicola Strain LL2208 Isolated from Chinese Longsnout Catfish (Leiocassis longirostris): Highly Similar to Human K. variicola Strains.
Research Article
The study identified a multidrug-resistant hypermucoviscous Klebsiella variicola strain LL2208 isolated from Chinese longsnout catfish, which exhibits resistance to various antibiotics including penicillins, macrolides, amphenicols, lincosamides, and glycopeptides. The strain possesses 30 antimicrobial resistance genes, including blaLEN-16, ompK37, pbp3, and vanG.
Molecular Epidemiology and In-Depth Characterization of Klebsiella pneumoniae Clinical Isolates from Armenia.
Research Article
The study identifies multiple AMR genes and mutations in K. pneumoniae isolates from Armenia, highlighting the presence of XDR and MDR strains with resistance to various antibiotics, including carbapenems, aminoglycosides, and quinolones.
The Microbiological Characteristics and Genomic Surveillance of Carbapenem-Resistant Klebsiella pneumoniae Isolated from Clinical Samples.
Research Article
The study identified multiple carbapenemase genes, including bla NDM-5, bla NDM-1, and bla OXA-232, as well as extended-spectrum beta-lactamases like bla CTX-M-15. Mutations in porin genes ompK36 and ompK37, and regulatory genes acrR and ramR, were associated with reduced susceptibility to carbapenems, cephalosporins, fluoroquinolones, and tigecycline.
Genomic Characterization of Pan-Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh.
Research Article
The study identifies 42 antimicrobial resistance (AMR) genes in the pan-drug resistant Klebsiella pneumoniae isolate KPNW, including beta-lactamases (bla CTX-M-15, bla NDM-1, bla OXA-1, bla TEM-63, bla TEM-104, bla SHV-28), tetracycline resistance genes (tet(A)), and efflux pump genes (oqxA, oqxB, marA, marR, ompK37, pbp3, crp, h-ns, kpnG, kpnH, parC, rsmA). Additionally, the isolate shows resistance to polymyxin B and colistin through modifications in lipid A (eptB, arnT, lptD, msbA, vanG) and other mechanisms.
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