ompp2

outer membrane porin

Validation StatusCandidate

Overview

Mechanism: amino acid substitutions and structural rearrangements reduce beta-lactam susceptibility
Validation Method: transformation and adhesion assays
Drug Classes: Chloramphenicol, Ampicillin, Cefotaxime, Ceftriaxone
Organisms: Haemophilus influenzae
Papers: 2
Databases: Reslit

Papers2

Haemophilus influenzae porine ompP2 gene transfer mediated by graphene oxide nanoparticles with effects on transformation process and virulence bacterial capacity.

PMID 24739467 · 2014

The ompP2 gene from a chloramphenicol-resistant H. influenzae strain was transferred using graphene oxide nanoparticles, leading to increased chloramphenicol resistance and adhesion to human cell lines.

Gene Information

Gene Name: ompp2
Allele: ompP2
Encodes: outer membrane porin
Source Database: Reslit
Confers Resistance To: Chloramphenicol
Organisms Tested In: • Haemophilus influenzae
Validation Method: transformation and adhesion assays
Sequence Accession: GI:2981106

Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen Haemophilus influenzae.

PMID 40980920 · 2025

The study identifies ftsI and ompP2 mutations as primary drivers of beta-lactam resistance in Haemophilus influenzae, with specific amino acid substitutions in ftsI and structural rearrangements in ompP2 contributing to increased MICs for ampicillin, cefotaxime, and ceftriaxone.

Gene Information

Gene Name: ompp2
Allele: ompP2
Encodes: outer membrane protein P2
Source Database: Reslit
Mechanism: amino acid substitutions and structural rearrangements reduce beta-lactam susceptibility
Confers Resistance To: AmpicillinCefotaximeCeftriaxone
Organisms Tested In: • Haemophilus influenzae
Validation Method: genomic sequencing and MIC testing
Sequence Accession: PRJEB86018

Comments (0)

No comments yet. Be the first to comment!

Browse AMR Genes

ompp2

Gene Information

Gene Information