oprA

outer membrane factor

Validation StatusCandidate

Overview

Mechanism: efflux pump component
Validation Method: experimental validation in P. aeruginosa PA7
Drug Classes: Aminoglycoside, Tetracycline, Erythromycin, Fluoroquinolone, Meropenem, Chloramphenicol, Levofloxacin, Azithromycin
Organisms: Pseudomonas aeruginosa, Escherichia coli
Papers: 2
Databases: Reslit

Papers2

MexXY multidrug efflux system of Pseudomonas aeruginosa.

PMID 23233851 · 2012

The study characterizes the MexXY multidrug efflux system in Pseudomonas aeruginosa, highlighting its role in aminoglycoside resistance. It also identifies related efflux systems in other bacteria such as AcrD in E. coli, AmrAB-OprA in B. pseudomallei, and AdeABC in A. baumannii.

Gene Information

Gene Name: oprA
Allele: OprA
Encodes: outer membrane factor
Source Database: Reslit
Confers Resistance To: AminoglycosideTetracyclineErythromycinFluoroquinolone
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: experimental validation in P. aeruginosa PA7

Targeting and ultrabroad insight into molecular basis of Resistance-nodulation-cell division efflux pumps.

PMID 36168028 · 2022

The study identifies key conserved residues in RND efflux pumps and evaluates the efficacy of potential inhibitors, highlighting the role of these pumps in multidrug resistance.

Gene Information

Gene Name: oprA
Allele: OprA
Encodes: outer membrane protein
Source Database: Reslit
Mechanism: efflux pump component
Confers Resistance To: TetracyclineMeropenemChloramphenicolLevofloxacinAzithromycin
Organisms Tested In: • Escherichia coli
Validation Method: molecular docking and molecular dynamics simulation

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oprA

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