Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
outer membrane protein
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G195D | - | - | Pseudomonas aeruginosa | Piperacillin/tazobactam|Ceftazidime|Cefepime|Meropenem|Imipenem|Tobramycin|Ciprofloxacin | Reslit | Candidate |
The regulatory repertoire of Pseudomonas aeruginosa AmpC ß-lactamase regulator AmpR includes virulence genes.
AmpR is a global regulator in P. aeruginosa that influences the expression of over 500 genes, including those involved in β-lactam resistance, virulence, and biofilm formation.
Development of a novel antimicrobial screening system targeting the pyoverdine-mediated iron acquisition system and xenobiotic efflux pumps.
The study developed a screening system targeting the iron acquisition system and the MexAB-OprM efflux pump in Pseudomonas aeruginosa. The oprM gene was placed downstream of the fpvA gene, allowing monitoring of iron acquisition system activity through antibiotic susceptibility. A compound, YH001, was identified that inhibits the MexAB-OprM efflux pump, enhancing the efficacy of aztreonam.
Differences in Gene Expression Profiles between Early and Late Isolates in Monospecies Achromobacter Biofilm.
The study identified upregulation of genes involved in antimicrobial resistance, including macrolide-specific efflux proteins MacA and MacB, RND-type multidrug resistance efflux pump genes AxyA and OprM, and a beta-lactamase gene, suggesting their role in the development of resistance in Achromobacter xylosoxidans.
Application of six multiplex PCR's among 200 clinical isolates of Pseudomonas aeruginosa for the detection of 20 drug resistance encoding genes.
The study identified several beta-lactamase genes (blaTem, blaOXA, blaCTX-M-15, blaVim, blaGes, blaVeb, blaDIM, AmpC) and efflux pump genes (MexA, MexB, OprM, MexC, MexD, OprJ, MexX, MexY, OprN, nfxB, MexR, OprD) in Pseudomonas aeruginosa clinical isolates, highlighting their roles in mediating resistance to various antibiotics.
Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression.
The study identifies two mechanisms by which Pseudomonas aeruginosa becomes resistant to the efflux pump inhibitor D13-9001: mutations in the target protein MexB and upregulation of the MexMN efflux pump. The MexMN pump was shown to efflux β-lactams and is not susceptible to inhibition by D13-9001.
Transcriptome Analysis Reveals the Resistance Mechanism of Pseudomonas aeruginosa to Tachyplesin I.
The study identifies several efflux pump genes, including mexB, mexC, mexR, armR, and others, that are upregulated in tachyplesin I-resistant Pseudomonas aeruginosa strains, suggesting their role in resistance through increased efflux of the antimicrobial peptide.
Full pathogen characterisation: species identification including the detection of virulence factors and antibiotic resistance genes via multiplex DNA-assays.
The study presents a DNA microarray-based assay for the simultaneous detection of 44 sepsis-relevant bacterial pathogens, 360 virulence factors, and 409 antibiotic resistance genes. The assay was evaluated with 14 multidrug-resistant strains, including all ESKAPE pathogens.
Clinically Relevant Concentrations of Polymyxin B and Meropenem Synergistically Kill Multidrug-Resistant Pseudomonas aeruginosa and Minimize Biofilm Formation.
The study identifies several AMR genes and mutations in multidrug-resistant Pseudomonas aeruginosa strains, including beta-lactamases, efflux pumps, and mutations in the pmrAB system, which contribute to resistance against polymyxins and other antibiotics.
Dynamic Adaptive Response of Pseudomonas aeruginosa to Clindamycin/Rifampicin-Impregnated Catheters.
The study identified the upregulation of several antibiotic resistance proteins in P. aeruginosa PAO1 exposed to clindamycin/rifampicin-impregnated catheters, including porins, efflux pumps, and ribosomal proteins, indicating an adaptive response to antibiotic pressure.
Targeting and ultrabroad insight into molecular basis of Resistance-nodulation-cell division efflux pumps.
The study identifies key conserved residues in RND efflux pumps and evaluates the efficacy of potential inhibitors, highlighting the role of these pumps in multidrug resistance.
A 10-year microbiological study of Pseudomonas aeruginosa strains revealed the circulation of populations resistant to both carbapenems and quaternary ammonium compounds.
The study identified blaVIM-2 and blaGES-5 as carbapenem resistance genes and the overexpression of the MexAB-OprM efflux pump as a mechanism for resistance to DDAC in Pseudomonas aeruginosa.
Whole-genome sequencing of Alcaligenes sp. strain MMA: insight into the antibiotic and heavy metal resistant genes.
The study identified multiple antibiotic resistance genes in Alcaligenes sp. strain MMA, including those conferring resistance to fluoroquinolones, tetracyclines, beta-lactams, penams, and macrolides. Additionally, the strain exhibited resistance to multiple heavy metals such as Cd, Ni, Cu, and Zn.
Bacterial diversity and resistome analysis of drinking water stored in cisterns from two First Nations communities in Manitoba, Canada.
The study identified a diverse array of antimicrobial resistance genes in drinking water stored in cisterns from two First Nations communities in Manitoba, Canada. Key findings include the presence of genes such as aac(3')-Ia, aac(6')-Iia, aac(6')-Iic, aph(3')-Ia, acrD, smeB, smeR, FEZ-1, rm3, SPG-1, OXA-21, OXA-119, OXA-205, dfrA14, dfrB6, acrB, acrF, adeF, ceoB, emrA, mexE, mexF, mexI, oprN, oqxB, BRP(MBL), vanSO, axyY, CRP, efrB, macB, mexB, mexC, mexD, mexK, mexQ, mexW, mexY, mtrA, muxB, muxC, oleB, oleC, ompB, oprM, smeD, smeE, golS, mdsB, PER-2, TEM-126, msbA, arnA, bacA, bcrA, MCR-5, rosA, rosB, rpoB2, ugd, mexN, taeA, efpA, rphA, rphB, otr(A), otrC, tetA(48 ), ompH, and triC, which confer resistance to various antibiotics including aminoglycosides, beta-lactams, cephalosporins, carbapenems, fluoroquinolones, macrolides, monobactams, nitroimidazoles, peptides, phenicols, pleuromutilins, rifamycins, tetracyclines, and triclosan.
Microbiological and molecular studies on a multidrug-resistant Pseudomonas aeruginosa from a liver transplant patient with urinary tract infection in Egypt.
The study identified 59 AMR genes in the multidrug-resistant P. aeruginosa strain EMARA01, with a focus on resistance-nodulation-cell division (RND) efflux pumps. Key genes include nalC, nalD, MexR, MexA, MexB, CpxR, and OprM, which confer resistance to multiple antibiotic classes.
From Proteome to Potential Drugs: Integration of Subtractive Proteomics and Ensemble Docking for Drug Repurposing against Pseudomonas aeruginosa RND Superfamily Proteins.
The study identifies and characterizes essential proteins in Pseudomonas aeruginosa, particularly RND efflux pumps, which are critical for antibiotic resistance. Computational methods and ensemble docking were used to find potential inhibitors like MK-3207, R-428, and Suramin, showing promise for drug repurposing.
Genomic characterization and drug resistance of Bordetella pseudohinzii first isolated from wild niviventer.
The study identifies multiple antibiotic resistance genes in Bordetella pseudohinzii, including efflux pumps and inactivating enzymes, leading to resistance against several cephalosporins.
Contribution of outer membrane efflux protein OprM to antibiotic resistance in Pseudomonas aeruginosa independent of MexAB.
The study shows that OprM contributes to antibiotic resistance in Pseudomonas aeruginosa independently of MexAB, through an energy-dependent efflux mechanism.
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