Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
multidrug efflux pump component
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| V130A | - | overexpression of oqxB and rarA | Klebsiella pneumoniae, Klebsiella quasipneumoniae | Chloramphenicol|CefoxitinTigecycline | Reslit | Candidate |
| M46I | - | - | Klebsiella quasipneumoniae | Tigecycline | Reslit | Candidate |
| E117A | - | - | Klebsiella quasipneumoniae | Tigecycline |
Reslit |
| Candidate |
| L188Q | - | - | - | Tigecycline | Reslit | Candidate |
| A30Q | - | - | - | Tigecycline | Reslit | Candidate |
| W185L | - | - | - | Tigecycline | Reslit | Candidate |
| A32D | - | - | Klebsiella pneumoniae | Chloramphenicol|Tetracycline|Ciprofloxacin | Reslit | Candidate |
| F6S | - | Rrf2 family transcriptional regulator OqxR | Klebsiella pneumoniae | NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE | Reference Gene Catalog | Established |
| V102G | - | Rrf2 family transcriptional regulator OqxR | Klebsiella pneumoniae | NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE | Reference Gene Catalog | Established |
| Q11L | - | Rrf2 family transcriptional regulator OqxR | Klebsiella pneumoniae | NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE | Reference Gene Catalog | Established |
| V113I | - | Rrf2 family transcriptional regulator OqxR | Klebsiella pneumoniae | NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE | Reference Gene Catalog | Established |
| D95E | - | Rrf2 family transcriptional regulator OqxR | Klebsiella pneumoniae | NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE | Reference Gene Catalog | Established |
| V130R | - | Rrf2 family transcriptional regulator OqxR | Klebsiella pneumoniae | NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE | Reference Gene Catalog | Established |
Nitroxoline resistance is associated with significant fitness loss and diminishes in vivo virulence of Escherichia coli.
The study identifies mutations in efflux-related genes such as emrR, emrA, emrB, marR, ramR, oqxR, iscR, and envZ as major contributors to nitroxoline resistance in E. coli and K. pneumoniae. These mutations lead to reduced susceptibility to nitroxoline and are associated with significant fitness loss and diminished in vivo virulence.
The investigation of molecular epidemiological characteristics and resistance mechanism of tigecycline resistant Klebsiella pneumoniae from a large teaching hospital in southwest China, Chongqing.
The study identified ramR, acrR, oqxR, and tet(A) as key genes contributing to tigecycline resistance in Klebsiella pneumoniae. Mutations in ramR, such as A19V, K63M, and I141T, were prevalent and associated with increased resistance. The tet(A) gene, particularly type 1 and type 3 variants, played a significant role in tigecycline resistance.
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