Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
O-acetyltransferase
Overview
Identification of Proteus mirabilis mutants with increased sensitivity to antimicrobial peptides.
The study identifies patA as a gene involved in lipid A modification, which contributes to resistance to polymyxin B in Proteus mirabilis. Mutants with disruptions in patA showed increased sensitivity to polymyxin B and lacked aminoarabinose in their lipid A.
Involvement of the putative ATP-dependent efflux proteins PatA and PatB in fluoroquinolone resistance of a multidrug-resistant mutant of Streptococcus pneumoniae.
The study identifies PatA and PatB as ATP-dependent efflux proteins involved in fluoroquinolone resistance in a multidrug-resistant mutant of Streptococcus pneumoniae.
The efflux pump inhibitor reserpine selects multidrug-resistant Streptococcus pneumoniae strains that overexpress the ABC transporters PatA and PatB.
The study identifies PatA and PatB as ABC transporters that confer multidrug resistance in Streptococcus pneumoniae. Overexpression of these transporters leads to resistance against fluoroquinolones, dyes, and disinfectants. Inactivation of patA reduces resistance to reserpine and fluoroquinolones, while inactivation of patB primarily affects multidrug resistance.
Helicobacter pylori peptidoglycan modifications confer lysozyme resistance and contribute to survival in the host.
The study identifies PgdA and PatA as peptidoglycan modification enzymes in Helicobacter pylori that confer lysozyme resistance. Both genes contribute synergistically to protect the bacterium from lysozyme-mediated killing, particularly in the presence of lactoferrin.
A novel gene amplification causes upregulation of the PatAB ABC transporter and fluoroquinolone resistance in Streptococcus pneumoniae.
A novel gene amplification leads to overexpression of the PatAB ABC transporter, resulting in fluoroquinolone resistance in Streptococcus pneumoniae.
Molecular Analysis of Rising Fluoroquinolone Resistance in Belgian Non-Invasive Streptococcus pneumoniae Isolates (1995-2014).
The study identifies several mutations in gyrA, gyrB, parC, and parE genes that contribute to fluoroquinolone resistance in Streptococcus pneumoniae. Additionally, overexpression of patA and patB efflux pump genes is associated with reduced susceptibility to ciprofloxacin.
Metagenomic read cloud sequencing reveals antibiotic resistance gene dynamics in the gut microbiome of a hematopoietic cell transplant patient
The study identified 46 antibiotic resistance genes in the pre-transplant E. coli strain, including genes conferring resistance to beta-lactams, aminoglycosides, polymyxins, bacitracin, and multiple drugs through efflux pumps.
Rapid MinION profiling of preterm microbiota and antimicrobial-resistant pathogens.
The study demonstrates the capability of MinION sequencing combined with NanoOK RT software to rapidly identify pathogens and their antimicrobial resistance gene profiles in preterm infants, enabling real-time diagnostics and resistance profiling.
Complete genome analysis of a virulent Vibrio scophthalmi strain VSc190401 isolated from diseased marine fish half-smooth tongue sole, Cynoglossus semilaevis.
The study identified several AMR genes in Vibrio scophthalmi strain VSc190401, including those conferring resistance to aminoglycosides, fluoroquinolones, tetracyclines, and polymyxins. Some of these genes were validated experimentally.
Epidemiological analysis of pneumococcal strains isolated at Yangon Children's Hospital in Myanmar via whole-genome sequencing-based methods.
The study identified multiple AMR genes and mutations in pneumococcal strains from Myanmar, including genes conferring resistance to azithromycin, tetracycline, chloramphenicol, and quinolones, as well as mutations in penicillin-binding proteins and DNA gyrase. These findings highlight the spread of AMR in pneumococcal strains in Myanmar.
The Genomic Characterization of KPC-Producing Klebsiella pneumoniae from the ICU of a Teaching Hospital in Shanghai, China.
The study identified the carbapenemase gene blaKPC-2 and blaKPC-24, along with fosfomycin resistance gene fosA6, and various extended-spectrum beta-lactamase genes such as blaCTX-M-15, blaCTX-M-65, and blaCTX-M-27 in KPC-producing Klebsiella pneumoniae strains. Additionally, genes associated with fluoroquinolone, macrolide, aminoglycoside, and sulfonamide resistance were also characterized.
Complete genome sequencing and comparative genomic analysis of three donkey Streptococcus equi subsp. equi isolates.
The study identified multiple antibiotic resistance genes in three donkey-derived Streptococcus equi subsp. equi isolates, including genes conferring resistance to beta-lactams, tetracyclines, macrolides, fluoroquinolones, and others. Notably, the HT1112 isolate showed resistance to six antimicrobials, while HTP133 and HTP232 showed resistance to fewer drugs. Additionally, the study highlighted the role of biofilm formation in antimicrobial resistance.
Airway "Resistotypes" and Clinical Outcomes in Bronchiectasis.
The study identifies distinct 'resistotypes' in bronchiectasis patients, showing associations with clinical outcomes, geographic origin, and the underlying microbiome. Targeted eradication of P. aeruginosa leads to a shift from a less favorable resistotype to a more favorable one.
Effect of erythromycin residuals in food on the development of resistance in Streptococcus pneumoniae: an in vivo study in Galleria mellonella.
Monitoring Changes in the Antimicrobial-Resistance Gene Set (ARG) of Raw Milk and Dairy Products in a Cattle Farm, from Production to Consumption.
The study identified 112 antibiotic-resistance genes in raw milk and dairy products, with a significant increase in resistant genes in aged cheese compared to raw milk. Key genes included OXA-662 and OXA-309, which confer resistance to beta-lactam antibiotics, and several efflux pump genes like abaQ, emrA, and acrAB-tolC, which contribute to fluoroquinolone resistance. The findings highlight the dynamic changes in the resistome during food processing and the potential public health risks associated with the spread of antibiotic resistance genes through raw dairy products.
Whole genome sequence and characterisation of Streptococcus suis 3112, isolated from snakeskin gourami, Trichopodus pectoralis.
The study identifies two fluoroquinolone resistance genes, patA and patB, in Streptococcus suis 3112, which confers resistance to norfloxacin but not to other fluoroquinolones.
Unlocking the Gates: A Novel Diagnostic Molecule for Quantifying Efflux Levels in Gram-Positive Bacteria.
The study identifies and characterizes several efflux pump genes (norA, mepA, bmrA, patA, and patB) in Gram-positive bacteria, demonstrating their role in mediating resistance to fluoroquinolones. A novel diagnostic molecule, 5a4, was developed to quantify efflux activity, showing promise for rapid and accurate detection of efflux-mediated resistance.
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