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pbp1a

penicillin-binding protein 1A

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to pbp1a

Browse AMR rules for pbp1a

Validation StatusSupported

Overview

Mechanism: mutation-induced resistance
Validation Method: transformation experiments with cloned pbp genes
Drug Classes: amoxicillin, ampicillin, cephalothin, penicillin
Organisms: Streptococcus pneumoniae, Helicobacter pylori
Geographic Location: France|Hungary
Alleles: 2
Papers: 6
Databases: Reslit
Mutations: 10

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
T371S	-	-	Streptococcus pneumoniae	amoxicillinpenicillin	Reslit	Candidate
V408L	-	-	Streptococcus pneumoniae	amoxicillin	Reslit	Candidate
R413H	-	-	Streptococcus pneumoniae	amoxicillin

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
pbp1a	Reslit	2	amoxicillin, penicillin	Streptococcus pneumoniae	France\|Hungary	2002, 2004	AF468662\|AF468663\|AF468664\|AF468665\|AF468666\|AF468667\|AF467811\|AF467812\|AF467813\|AF467814\|AF467815\|AF467816\|AF467817\|AF467818\|AF467819\|AF467820\|AF467821\|AF467822	-
pbp-1A	Reslit	1	amoxicillin, ampicillin +2	Helicobacter pylori	-	2003	AY241260\|AY241259	-

Papers6

1

Analysis of penicillin-binding protein genes of clinical isolates of Streptococcus pneumoniae with reduced susceptibility to amoxicillin.

PMID 12121904 · 2002

The study identifies mutations in penicillin-binding protein genes (pbp2x, pbp2b, pbp1a) and the murMN resistance determinant as contributors to amoxicillin and penicillin resistance in Streptococcus pneumoniae isolates.

Gene Information

Gene Name: pbp1a
Allele: pbp1a
Encodes: penicillin-binding protein 1A
Source Database: Reslit
Mechanism: mutation-induced resistance
Confers Resistance To: amoxicillin
Organisms Tested In: • Streptococcus pneumoniae
Geographic Location: France|Hungary
Validation Method: transformation experiments with cloned pbp genes
Sequence Accession: AF468662|AF468663|AF468664|AF468665|AF468666|AF468667|AF467811|AF467812|AF467813|AF467814|AF467815|AF467816|AF467817|AF467818|AF467819|AF467820|AF467821|AF467822

2

High-level beta-lactam resistance associated with acquired multidrug resistance in Helicobacter pylori.

PMID 12821464 · 2003

The study identifies pbp-1A as a gene responsible for high-level beta-lactam resistance in Helicobacter pylori, which is associated with acquired multidrug resistance. The resistance is mediated by alterations in the C-terminal portion of PBP 1A and decreased membrane permeability.

Gene Information

Gene Name: pbp1a
Allele: pbp-1A
Encodes: penicillin binding protein 1A
Source Database: Reslit
Confers Resistance To: amoxicillinampicillincephalothinpenicillin
Organisms Tested In: • Helicobacter pylori
Validation Method: DNA sequence analysis and natural transformation
Sequence Accession: AY241260|AY241259

3

Single-step capsular transformation and acquisition of penicillin resistance in Streptococcus pneumoniae.

PMID 15150231 · 2004

The study demonstrates that a single transformation event can lead to the acquisition of penicillin resistance and a new capsular type in Streptococcus pneumoniae, highlighting the role of pbp2x and pbp1a mutations in this process.

Gene Information

Gene Name: pbp1a
Allele: pbp1a
Encodes: penicillin-binding protein
Source Database: Reslit
Mechanism: mutation
Confers Resistance To: penicillin
Organisms Tested In: • Streptococcus pneumoniae
Validation Method: transformation and RFLP analysis